Induction of micronuclei in mouse and rat by glycidamide, genotoxic metabolite of acrylamide

Male CBA mice and male Sprague–Dawley rats were treated by i.p. injection of glycidamide (GA), the presumed genotoxic metabolite of acrylamide (AA). GA was obtained through a new way of synthesis. As an endpoint of chromosome damage, micronucleus (MN) induction in erythrocytes was measured. Hemoglob...

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Veröffentlicht in:	Mutation research 2003-02, Vol.535 (1), p.15-24
Hauptverfasser:	Paulsson, Birgit, Kotova, Natalia, Grawé, Jan, Henderson, Alistair, Granath, Fredrik, Golding, Bernard, Törnqvist, Margareta
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide Acrylamide - administration & dosage Acrylamide - metabolism Acrylamide - toxicity Animals Biological and medical sciences Carcinogenic Chemical mutagenesis Dose-Response Relationship, Drug Epoxy Compounds - administration & dosage Epoxy Compounds - metabolism Epoxy Compounds - toxicity Erythrocytes - drug effects Erythrocytes - metabolism Erythrocytes - ultrastructure Fundamental and applied biological sciences. Psychology Glycidamide Hemoglobin adducts Hemoglobins - chemistry Hemoglobins - drug effects Male Medical sciences Mice Mice, Inbred CBA Micronuclei Micronuclei, Chromosome-Defective - drug effects Micronucleus Tests Molecular and cellular biology Molecular genetics Mutagenesis. Repair Mutagens - administration & dosage Mutagens - toxicity Rats Rats, Sprague-Dawley Toxicology
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