On the Role of Liver X Receptors in Lipid Accumulation in Adipocytes

The pivotal role of liver X receptors (LXRs) in the metabolic conversion of cholesterol to bile acids in mice is well established. More recently, the LXRα promoter has been shown to be under tight regulation by peroxisome proliferator-activated receptors (PPARs), implying a role for LXRα in mediatin...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2003-02, Vol.17 (2), p.172-182
Hauptverfasser:	Juvet, Lene K, Andresen, Sissel M, Schuster, Gertrud U, Dalen, Knut Tomas, Tobin, Kari Anne R, Hollung, Kristin, Haugen, Fred, Jacinto, Severina, Ulven, Stine M, Bamberg, Krister, Gustafsson, Jan-Åke, Nebb, Hilde I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - drug effects Adipocytes - metabolism Adipose Tissue - drug effects Animals Anticholesteremic Agents - pharmacology CCAAT-Enhancer-Binding Proteins - drug effects CCAAT-Enhancer-Binding Proteins - genetics Cells, Cultured Desmosterol - analogs & derivatives Desmosterol - pharmacology DNA-Binding Proteins - drug effects DNA-Binding Proteins - genetics Fatty Acid Synthases - drug effects Fatty Acid Synthases - genetics Female Gene Expression Regulation Humans Hydrocarbons, Fluorinated Lipid Metabolism Liver X Receptors Male Mice Mice, Inbred C57BL Mice, Knockout Obesity - drug therapy Obesity - genetics Orphan Nuclear Receptors Rats Rats, Zucker Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Cytoplasmic and Nuclear - physiology Sterol Regulatory Element Binding Protein 1 Sulfonamides Thiazoles - pharmacology Thiazolidinediones Transcription Factors - agonists Transcription Factors - metabolism Transcription, Genetic Up-Regulation
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