Upregulation of the apoptosis regulators cFLIP, CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing–remitting multiple sclerosis

Multiple sclerosis (MS) is a chronic disease involving an inflammatory reaction within the white matter of the CNS, mediated by T cells, B cells and macrophages. The pathogenesis of MS may involve impaired activation-induced cell death of activated myelin-specific mature T cells. We investigated the...

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Veröffentlicht in:	Journal of neuroimmunology 2003-02, Vol.135 (1), p.126-134
Hauptverfasser:	Gomes, Andreia C, Jönsson, Gun, Mjörnheim, Susanna, Olsson, Tomas, Hillert, Jan, Grandien, Alf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Apoptosis Carrier Proteins - cerebrospinal fluid Carrier Proteins - genetics CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 8 Caspase 9 Caspases - genetics CD95 Cell Line cFLIP Fas Ligand Protein fas Receptor - cerebrospinal fluid fas Receptor - genetics Female Gene Expression Regulation Humans Intracellular Signaling Peptides and Proteins Leukocytes, Mononuclear - metabolism Lymphocytes Male Medicin och hälsovetenskap Membrane Glycoproteins - cerebrospinal fluid Membrane Glycoproteins - genetics Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - immunology Polymerase Chain Reaction RNA, Messenger - analysis Time Factors Up-Regulation
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