Upregulation of the apoptosis regulators cFLIP, CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing–remitting multiple sclerosis
Multiple sclerosis (MS) is a chronic disease involving an inflammatory reaction within the white matter of the CNS, mediated by T cells, B cells and macrophages. The pathogenesis of MS may involve impaired activation-induced cell death of activated myelin-specific mature T cells. We investigated the...
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| Veröffentlicht in: | Journal of neuroimmunology 2003-02, Vol.135 (1), p.126-134 |
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| creator | Gomes, Andreia C Jönsson, Gun Mjörnheim, Susanna Olsson, Tomas Hillert, Jan Grandien, Alf |
| description | Multiple sclerosis (MS) is a chronic disease involving an inflammatory reaction within the white matter of the CNS, mediated by T cells, B cells and macrophages. The pathogenesis of MS may involve impaired activation-induced cell death of activated myelin-specific mature T cells. We investigated the mRNA expression of the apoptosis mediators cellular FLICE-inhibitory protein (cFLIP), caspase-8, CD95 and CD95L in peripheral blood mononuclear cells (PB MNCs) from MS patients using real-time PCR. The overall increased expression of the four key players in the CD95 pathway in relapsing-remitting MS suggests their involvement in the inflammatory process in this disease. |
| doi_str_mv | 10.1016/S0165-5728(02)00437-X |
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The pathogenesis of MS may involve impaired activation-induced cell death of activated myelin-specific mature T cells. We investigated the mRNA expression of the apoptosis mediators cellular FLICE-inhibitory protein (cFLIP), caspase-8, CD95 and CD95L in peripheral blood mononuclear cells (PB MNCs) from MS patients using real-time PCR. The overall increased expression of the four key players in the CD95 pathway in relapsing-remitting MS suggests their involvement in the inflammatory process in this disease.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/S0165-5728(02)00437-X</identifier><identifier>PMID: 12576232</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Age Factors ; Aged ; Apoptosis ; Carrier Proteins - cerebrospinal fluid ; Carrier Proteins - genetics ; CASP8 and FADD-Like Apoptosis Regulating Protein ; Caspase 8 ; Caspase 9 ; Caspases - genetics ; CD95 ; Cell Line ; cFLIP ; Fas Ligand Protein ; fas Receptor - cerebrospinal fluid ; fas Receptor - genetics ; Female ; Gene Expression Regulation ; Humans ; Intracellular Signaling Peptides and Proteins ; Leukocytes, Mononuclear - metabolism ; Lymphocytes ; Male ; Medicin och hälsovetenskap ; Membrane Glycoproteins - cerebrospinal fluid ; Membrane Glycoproteins - genetics ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis, Relapsing-Remitting - immunology ; Polymerase Chain Reaction ; RNA, Messenger - analysis ; Time Factors ; Up-Regulation</subject><ispartof>Journal of neuroimmunology, 2003-02, Vol.135 (1), p.126-134</ispartof><rights>2002 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-4d0f6f80aec82441e945a81a8b1be3f05fd8c4a4df3ba30c051d680285e2d0423</citedby><cites>FETCH-LOGICAL-c544t-4d0f6f80aec82441e945a81a8b1be3f05fd8c4a4df3ba30c051d680285e2d0423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-5728(02)00437-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12576232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1961294$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomes, Andreia C</creatorcontrib><creatorcontrib>Jönsson, Gun</creatorcontrib><creatorcontrib>Mjörnheim, Susanna</creatorcontrib><creatorcontrib>Olsson, Tomas</creatorcontrib><creatorcontrib>Hillert, Jan</creatorcontrib><creatorcontrib>Grandien, Alf</creatorcontrib><title>Upregulation of the apoptosis regulators cFLIP, CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing–remitting multiple sclerosis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Multiple sclerosis (MS) is a chronic disease involving an inflammatory reaction within the white matter of the CNS, mediated by T cells, B cells and macrophages. The pathogenesis of MS may involve impaired activation-induced cell death of activated myelin-specific mature T cells. We investigated the mRNA expression of the apoptosis mediators cellular FLICE-inhibitory protein (cFLIP), caspase-8, CD95 and CD95L in peripheral blood mononuclear cells (PB MNCs) from MS patients using real-time PCR. The overall increased expression of the four key players in the CD95 pathway in relapsing-remitting MS suggests their involvement in the inflammatory process in this disease.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Apoptosis</subject><subject>Carrier Proteins - cerebrospinal fluid</subject><subject>Carrier Proteins - genetics</subject><subject>CASP8 and FADD-Like Apoptosis Regulating Protein</subject><subject>Caspase 8</subject><subject>Caspase 9</subject><subject>Caspases - genetics</subject><subject>CD95</subject><subject>Cell Line</subject><subject>cFLIP</subject><subject>Fas Ligand Protein</subject><subject>fas Receptor - cerebrospinal fluid</subject><subject>fas Receptor - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Membrane Glycoproteins - cerebrospinal fluid</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis, Relapsing-Remitting - immunology</subject><subject>Polymerase Chain Reaction</subject><subject>RNA, Messenger - analysis</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksGK1TAUhosoznX0EZSsRMFqkiZtuhK5OjpwQUEHZhfS5PRONG1i0irufAfBB_RJTKfXmZXMJvk5-f5zwuEviocEPyeY1C8-5oOXvKHiCaZPMWZVU57fKjZENLQUjJLbxeYKOSrupfQZY8Ir1t4tjgjlTU0ruil-n4UI-9mpyfoR-R5NF4BU8GHyySZ0ePMxIX2yO_3wDG1ftxyp0azC2f2i7YgCRBsuICqHOue9QYMf_ThrByoiDc6lhYrgVEh23P_5-SvCYKcpazTMbrLBAUoZj8vg-8WdXrkEDw73cXF28ubT9l25e__2dPtqV2rO2FQyg_u6F1iBFpQxAi3jShAlOtJB1WPeG6GZYqavOlVhjTkxtcBUcKAGM1odF-XaN32HMHcyRDuo-EN6ZeWh9CUrkLwluKoz3_yXD9Gba9M_I2lrQluWnY9XZ8a-zpAmOdi07EWN4OckmwoTwUVzI0hELXJPkUG-gjqvLEXor35DsFwyIi8zIpcASEzlZUbkefY9OgyYuwHMtesQigy8XAHIm_9mIcqkLYwajI2gJ2m8vWHEX3eo0LU</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Gomes, Andreia C</creator><creator>Jönsson, Gun</creator><creator>Mjörnheim, Susanna</creator><creator>Olsson, Tomas</creator><creator>Hillert, Jan</creator><creator>Grandien, Alf</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20030201</creationdate><title>Upregulation of the apoptosis regulators cFLIP, CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing–remitting multiple sclerosis</title><author>Gomes, Andreia C ; Jönsson, Gun ; Mjörnheim, Susanna ; Olsson, Tomas ; Hillert, Jan ; Grandien, Alf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-4d0f6f80aec82441e945a81a8b1be3f05fd8c4a4df3ba30c051d680285e2d0423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Apoptosis</topic><topic>Carrier Proteins - cerebrospinal fluid</topic><topic>Carrier Proteins - genetics</topic><topic>CASP8 and FADD-Like Apoptosis Regulating Protein</topic><topic>Caspase 8</topic><topic>Caspase 9</topic><topic>Caspases - genetics</topic><topic>CD95</topic><topic>Cell Line</topic><topic>cFLIP</topic><topic>Fas Ligand Protein</topic><topic>fas Receptor - cerebrospinal fluid</topic><topic>fas Receptor - genetics</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Membrane Glycoproteins - cerebrospinal fluid</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis, Relapsing-Remitting - immunology</topic><topic>Polymerase Chain Reaction</topic><topic>RNA, Messenger - analysis</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomes, Andreia C</creatorcontrib><creatorcontrib>Jönsson, Gun</creatorcontrib><creatorcontrib>Mjörnheim, Susanna</creatorcontrib><creatorcontrib>Olsson, Tomas</creatorcontrib><creatorcontrib>Hillert, Jan</creatorcontrib><creatorcontrib>Grandien, Alf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomes, Andreia C</au><au>Jönsson, Gun</au><au>Mjörnheim, Susanna</au><au>Olsson, Tomas</au><au>Hillert, Jan</au><au>Grandien, Alf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of the apoptosis regulators cFLIP, CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing–remitting multiple sclerosis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>135</volume><issue>1</issue><spage>126</spage><epage>134</epage><pages>126-134</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Multiple sclerosis (MS) is a chronic disease involving an inflammatory reaction within the white matter of the CNS, mediated by T cells, B cells and macrophages. The pathogenesis of MS may involve impaired activation-induced cell death of activated myelin-specific mature T cells. We investigated the mRNA expression of the apoptosis mediators cellular FLICE-inhibitory protein (cFLIP), caspase-8, CD95 and CD95L in peripheral blood mononuclear cells (PB MNCs) from MS patients using real-time PCR. The overall increased expression of the four key players in the CD95 pathway in relapsing-remitting MS suggests their involvement in the inflammatory process in this disease.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>12576232</pmid><doi>10.1016/S0165-5728(02)00437-X</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Apoptosis Carrier Proteins - cerebrospinal fluid Carrier Proteins - genetics CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 8 Caspase 9 Caspases - genetics CD95 Cell Line cFLIP Fas Ligand Protein fas Receptor - cerebrospinal fluid fas Receptor - genetics Female Gene Expression Regulation Humans Intracellular Signaling Peptides and Proteins Leukocytes, Mononuclear - metabolism Lymphocytes Male Medicin och hälsovetenskap Membrane Glycoproteins - cerebrospinal fluid Membrane Glycoproteins - genetics Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - immunology Polymerase Chain Reaction RNA, Messenger - analysis Time Factors Up-Regulation |
| title | Upregulation of the apoptosis regulators cFLIP, CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing–remitting multiple sclerosis |
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