Impact of Age and Sex in Ultraviolet Radiation Cataract in the Rat
The purpose of this study was to determine the influence of age and sex on the development of ultraviolet radiation (UVR) cataract in rats. Current safety limits for lens damage due to UVR do not consider age or sex. Four age groups of Sprague-Dawley rats (3, 6, 17, and 52 weeks) were exposed to 300...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2003-04, Vol.44 (4), p.1629-1633 |
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| creator | Lofgren, Stefan Michael, Ralph Soderberg, Per G |
| description | The purpose of this study was to determine the influence of age and sex on the development of ultraviolet radiation (UVR) cataract in rats. Current safety limits for lens damage due to UVR do not consider age or sex.
Four age groups of Sprague-Dawley rats (3, 6, 17, and 52 weeks) were exposed to 300-nm UVR at either 5 or 8 kJ/m(2), delivered during 15 minutes. The interval between irradiation and cataract assessment was 1 or 8 weeks. Moreover, two groups of 6-week-old male and female rats were exposed to 5 kJ/m(2) UVR, with cataract assessment after 1 week. The severity of cataract was quantified by measurement of forward light-scattering in isolated lenses.
The youngest age group showed development of anterior subcapsular, equatorial, and nuclear cataract, whereas the three older groups exhibited the first two types. The two younger age groups had significantly more cataract than the other groups. The degree of cataract increased from 1 to 8 weeks after irradiation. There was no difference in cataract severity between sexes.
Young rats are more sensitive to UVR than old rats. Nuclear UVR cataract develops in young rats but not in adult rats. With the chosen waveband and dose, the time for maximum cataract development to occur is longer than 1 week. There is no difference in UVR sensitivity between the sexes. |
| doi_str_mv | 10.1167/iovs.01-0922 |
| format | Article |
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Four age groups of Sprague-Dawley rats (3, 6, 17, and 52 weeks) were exposed to 300-nm UVR at either 5 or 8 kJ/m(2), delivered during 15 minutes. The interval between irradiation and cataract assessment was 1 or 8 weeks. Moreover, two groups of 6-week-old male and female rats were exposed to 5 kJ/m(2) UVR, with cataract assessment after 1 week. The severity of cataract was quantified by measurement of forward light-scattering in isolated lenses.
The youngest age group showed development of anterior subcapsular, equatorial, and nuclear cataract, whereas the three older groups exhibited the first two types. The two younger age groups had significantly more cataract than the other groups. The degree of cataract increased from 1 to 8 weeks after irradiation. There was no difference in cataract severity between sexes.
Young rats are more sensitive to UVR than old rats. Nuclear UVR cataract develops in young rats but not in adult rats. With the chosen waveband and dose, the time for maximum cataract development to occur is longer than 1 week. There is no difference in UVR sensitivity between the sexes.</description><identifier>ISSN: 0146-0404</identifier><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.01-0922</identifier><identifier>PMID: 12657602</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Age Factors ; Animals ; Biological and medical sciences ; Cataract - etiology ; Cataract - pathology ; Female ; Lens diseases ; Lens, Crystalline - pathology ; Lens, Crystalline - radiation effects ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Ophthalmology ; Radiation Injuries, Experimental - etiology ; Radiation Injuries, Experimental - pathology ; Rats ; Rats, Sprague-Dawley ; Scattering, Radiation ; Sex Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the eye and orbit ; Ultraviolet Rays</subject><ispartof>Investigative ophthalmology & visual science, 2003-04, Vol.44 (4), p.1629-1633</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-7a8d64a1b47006918815e0e82d6e20de871b53f8da50438a3b77ca7d8b318c863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14684859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12657602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1944029$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Lofgren, Stefan</creatorcontrib><creatorcontrib>Michael, Ralph</creatorcontrib><creatorcontrib>Soderberg, Per G</creatorcontrib><title>Impact of Age and Sex in Ultraviolet Radiation Cataract in the Rat</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>The purpose of this study was to determine the influence of age and sex on the development of ultraviolet radiation (UVR) cataract in rats. Current safety limits for lens damage due to UVR do not consider age or sex.
Four age groups of Sprague-Dawley rats (3, 6, 17, and 52 weeks) were exposed to 300-nm UVR at either 5 or 8 kJ/m(2), delivered during 15 minutes. The interval between irradiation and cataract assessment was 1 or 8 weeks. Moreover, two groups of 6-week-old male and female rats were exposed to 5 kJ/m(2) UVR, with cataract assessment after 1 week. The severity of cataract was quantified by measurement of forward light-scattering in isolated lenses.
The youngest age group showed development of anterior subcapsular, equatorial, and nuclear cataract, whereas the three older groups exhibited the first two types. The two younger age groups had significantly more cataract than the other groups. The degree of cataract increased from 1 to 8 weeks after irradiation. There was no difference in cataract severity between sexes.
Young rats are more sensitive to UVR than old rats. Nuclear UVR cataract develops in young rats but not in adult rats. With the chosen waveband and dose, the time for maximum cataract development to occur is longer than 1 week. There is no difference in UVR sensitivity between the sexes.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cataract - etiology</subject><subject>Cataract - pathology</subject><subject>Female</subject><subject>Lens diseases</subject><subject>Lens, Crystalline - pathology</subject><subject>Lens, Crystalline - radiation effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Ophthalmology</subject><subject>Radiation Injuries, Experimental - etiology</subject><subject>Radiation Injuries, Experimental - pathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Scattering, Radiation</subject><subject>Sex Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Ultraviolet Rays</subject><issn>0146-0404</issn><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EotvCrWeUCz01ZcbxV47tqqWVKiEBPVuT2Om6ZDcrO23Kv8fRLuyJk0ee53ltvYydIlwgKv0lDC_pArCEmvM3bIFS8lJqU71lC0ChShAgjthxSk8AHJHDe3aEXEmtgC_Y1d16S-1YDF1x-egL2rjih38twqZ46MdIL2Ho_Vh8JxdoDMOmWNJIcRYyMa583owf2LuO-uQ_7s8T9nBz_XN5W95_-3q3vLwvW1GJsdRknBKEjdAAqkZjUHrwhjvlOThvNDay6owjCaIyVDVat6SdaSo0rVHVCSt3uWny2-fGbmNYU_xtBwp2f_UrT97KGoSCzOv_8ts4uIP0V8RaCOB1Ns93ZhuHlKLv_rkIdi7dzqVbQDuXnvFPOzynrb07wPuWM_B5D1Bqqe8ibdqQDpxQRhg5v3u241bhcTWF6G1aU9_nWLTTNAlhhUWVP_gHOMuXXw</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Lofgren, Stefan</creator><creator>Michael, Ralph</creator><creator>Soderberg, Per G</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20030401</creationdate><title>Impact of Age and Sex in Ultraviolet Radiation Cataract in the Rat</title><author>Lofgren, Stefan ; Michael, Ralph ; Soderberg, Per G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-7a8d64a1b47006918815e0e82d6e20de871b53f8da50438a3b77ca7d8b318c863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cataract - etiology</topic><topic>Cataract - pathology</topic><topic>Female</topic><topic>Lens diseases</topic><topic>Lens, Crystalline - pathology</topic><topic>Lens, Crystalline - radiation effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Ophthalmology</topic><topic>Radiation Injuries, Experimental - etiology</topic><topic>Radiation Injuries, Experimental - pathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Scattering, Radiation</topic><topic>Sex Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the eye and orbit</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lofgren, Stefan</creatorcontrib><creatorcontrib>Michael, Ralph</creatorcontrib><creatorcontrib>Soderberg, Per G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lofgren, Stefan</au><au>Michael, Ralph</au><au>Soderberg, Per G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Age and Sex in Ultraviolet Radiation Cataract in the Rat</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>44</volume><issue>4</issue><spage>1629</spage><epage>1633</epage><pages>1629-1633</pages><issn>0146-0404</issn><issn>1552-5783</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>The purpose of this study was to determine the influence of age and sex on the development of ultraviolet radiation (UVR) cataract in rats. Current safety limits for lens damage due to UVR do not consider age or sex.
Four age groups of Sprague-Dawley rats (3, 6, 17, and 52 weeks) were exposed to 300-nm UVR at either 5 or 8 kJ/m(2), delivered during 15 minutes. The interval between irradiation and cataract assessment was 1 or 8 weeks. Moreover, two groups of 6-week-old male and female rats were exposed to 5 kJ/m(2) UVR, with cataract assessment after 1 week. The severity of cataract was quantified by measurement of forward light-scattering in isolated lenses.
The youngest age group showed development of anterior subcapsular, equatorial, and nuclear cataract, whereas the three older groups exhibited the first two types. The two younger age groups had significantly more cataract than the other groups. The degree of cataract increased from 1 to 8 weeks after irradiation. There was no difference in cataract severity between sexes.
Young rats are more sensitive to UVR than old rats. Nuclear UVR cataract develops in young rats but not in adult rats. With the chosen waveband and dose, the time for maximum cataract development to occur is longer than 1 week. There is no difference in UVR sensitivity between the sexes.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>12657602</pmid><doi>10.1167/iovs.01-0922</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Age Factors Animals Biological and medical sciences Cataract - etiology Cataract - pathology Female Lens diseases Lens, Crystalline - pathology Lens, Crystalline - radiation effects Male Medical sciences Medicin och hälsovetenskap Ophthalmology Radiation Injuries, Experimental - etiology Radiation Injuries, Experimental - pathology Rats Rats, Sprague-Dawley Scattering, Radiation Sex Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Ultraviolet Rays |
| title | Impact of Age and Sex in Ultraviolet Radiation Cataract in the Rat |
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