Partial purification and characterization of gamma-secretase from post-mortem human brain

One characteristic feature of Alzheimer's disease is the deposition of amyloid beta-peptide (Abeta) as amyloid plaques within specific regions of the human brain. Abeta is derived from the amyloid beta-peptide precursor protein (beta-APP) by the intramembranous cleavage activity of gamma-secret...

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Veröffentlicht in:	The Journal of biological chemistry 2003-07, Vol.278 (27), p.24277-24284
Hauptverfasser:	Farmery, Mark R, Tjernberg, Lars O, Pursglove, Sharon E, Bergman, Anna, Winblad, Bengt, Näslund, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - enzymology Amyloid beta-Peptides - analysis Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Biological Assay Brain - enzymology Cadaver Endopeptidases - analysis Endopeptidases - isolation & purification Endopeptidases - metabolism Fluorescent Dyes Humans In Vitro Techniques
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