Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2

Deletion of a part of the short arm of chromosome 1 is one of the most common chromosomal rearrangements observed in neuroblastoma (NBL) tumors and it is associated with a poor prognosis. No NBL tumor suppressor gene has yet been identified in the region. Our shortest region of overlap of deletions,...

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Veröffentlicht in:	Oncogene 2003-04, Vol.22 (15), p.2343-2351
Hauptverfasser:	Krona, Cecilia, Ejeskär, Katarina, Abel, Frida, Kogner, Per, Bjelke, Jill, Björk, Elin, Sjöberg, Rose-Marie, Martinsson, Tommy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Apoptosis Biological and medical sciences biosynthesis Cell Biology Chromosome 1 Chromosome deletion Chromosome rearrangements Chromosomes Chromosomes, Human, Pair 1 - genetics Classical genetics, quantitative genetics, hybrids Cysteine Endopeptidases Cysteine Endopeptidases - metabolism Deoxyribonucleic acid DNA DNA Mutational Analysis DNA, Neoplasm - genetics Fundamental and applied biological sciences. Psychology Gene Deletion Gene Expression Profiling Gene Expression Regulation Gene Expression Regulation, Neoplastic Genes Genes, Tumor Suppressor Genetic screening genetics Genetics of eukaryotes. Biological and molecular evolution Human Human Genetics Humans Internal Medicine Loss of Heterozygosity Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Medicine Medicine & Public Health metabolism Multienzyme Complexes Multienzyme Complexes - metabolism Mutation Neoplasm Neoplasm Proteins Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Staging Neoplastic Neuroblastoma Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Neurology Nucleotide sequence oncogenomics Oncology Pair 1 pathology Prognosis Proteasome Endopeptidase Complex Reverse Transcriptase Polymerase Chain Reaction RNA Splice Sites RNA Splice Sites - genetics Treatment Outcome Tumor Suppressor Tumor suppressor genes Tumor Suppressor Proteins Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics Tumors Tumors of the nervous system. Phacomatoses Ubiquitin Ubiquitin - metabolism Ubiquitin-Protein Ligase Complexes
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