Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study
There is increasing evidence of an inverse association between use of nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of colorectal cancer. However, data regarding other cancer sites are limited. Using data from the population-based North Jutland Prescription Database and the Danish Cancer Re...
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| Veröffentlicht in: | British journal of cancer 2003-06, Vol.88 (11), p.1687-1692 |
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| creator | Sørensen, H T Friis, S Nørgård, B Mellemkjær, L Blot, W J McLaughlin, J K Ekbom, A Baron, J A |
| description | There is increasing evidence of an inverse association between use of nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of colorectal cancer. However, data regarding other cancer sites are limited. Using data from the population-based North Jutland Prescription Database and the Danish Cancer Registry, we compared cancer incidence among 172 057 individuals prescribed nonaspirin NSAIDs with expected incidence (based on county-specific cancer rates) during a 9-year study period. A total of 6081 incident cancer cases were diagnosed among NSAID users
vs
5722 expected (standardised incidence ratio (SIR) 1.1, 95% confidence interval (CI)1.0–1.1). The SIRs for colon and rectal cancer among persons who obtained 10 or more prescriptions were 0.7 (95% CI 0.6–0.9) and 0.6 (95% CI 0.4–0.9), respectively. Similarly, reduced risk estimates were found for stomach (SIR 0.7, 95% CI 0.4–1.1) and ovarian cancer (SIR 0.7, 95% CI 0.4–1.0). Standardised incidence ratios for other cancers among those with 10 or more prescriptions tended to be close to 1.0, except for lung, kidney, and prostate cancers with SIRs of 1.3 (95% CI 1.1–1.6), 1.4 (95% CI 0.9–2.1), and 1.6 (95% CI 1.3–2.0), respectively. We found protective associations of NSAIDs against colon, rectal, stomach, and ovarian cancer. Reasons for the increased risk for some cancer sites are not clear. |
| doi_str_mv | 10.1038/sj.bjc.6600945 |
| format | Article |
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vs
5722 expected (standardised incidence ratio (SIR) 1.1, 95% confidence interval (CI)1.0–1.1). The SIRs for colon and rectal cancer among persons who obtained 10 or more prescriptions were 0.7 (95% CI 0.6–0.9) and 0.6 (95% CI 0.4–0.9), respectively. Similarly, reduced risk estimates were found for stomach (SIR 0.7, 95% CI 0.4–1.1) and ovarian cancer (SIR 0.7, 95% CI 0.4–1.0). Standardised incidence ratios for other cancers among those with 10 or more prescriptions tended to be close to 1.0, except for lung, kidney, and prostate cancers with SIRs of 1.3 (95% CI 1.1–1.6), 1.4 (95% CI 0.9–2.1), and 1.6 (95% CI 1.3–2.0), respectively. We found protective associations of NSAIDs against colon, rectal, stomach, and ovarian cancer. Reasons for the increased risk for some cancer sites are not clear.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6600945</identifier><identifier>PMID: 12771981</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aged ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cohort Studies ; Colorectal Neoplasms - prevention & control ; Denmark - epidemiology ; Drug Resistance ; Epidemiology ; Female ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Molecular Medicine ; Neoplasms - epidemiology ; Neoplasms - prevention & control ; Oncology ; Ovarian Neoplasms - prevention & control ; Population Surveillance ; Registries ; Risk Factors ; Stomach Neoplasms - prevention & control ; Tumors</subject><ispartof>British journal of cancer, 2003-06, Vol.88 (11), p.1687-1692</ispartof><rights>The Author(s) 2003</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 2, 2003</rights><rights>Copyright © 2003 Cancer Research UK 2003 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-19c4b64c3ed2159d4f43818cc6474fe9178f14f5ac2e0ba571d059335cb193183</citedby><cites>FETCH-LOGICAL-c587t-19c4b64c3ed2159d4f43818cc6474fe9178f14f5ac2e0ba571d059335cb193183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377131/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377131/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14850818$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12771981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1933943$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Sørensen, H T</creatorcontrib><creatorcontrib>Friis, S</creatorcontrib><creatorcontrib>Nørgård, B</creatorcontrib><creatorcontrib>Mellemkjær, L</creatorcontrib><creatorcontrib>Blot, W J</creatorcontrib><creatorcontrib>McLaughlin, J K</creatorcontrib><creatorcontrib>Ekbom, A</creatorcontrib><creatorcontrib>Baron, J A</creatorcontrib><title>Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>There is increasing evidence of an inverse association between use of nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of colorectal cancer. However, data regarding other cancer sites are limited. Using data from the population-based North Jutland Prescription Database and the Danish Cancer Registry, we compared cancer incidence among 172 057 individuals prescribed nonaspirin NSAIDs with expected incidence (based on county-specific cancer rates) during a 9-year study period. A total of 6081 incident cancer cases were diagnosed among NSAID users
vs
5722 expected (standardised incidence ratio (SIR) 1.1, 95% confidence interval (CI)1.0–1.1). The SIRs for colon and rectal cancer among persons who obtained 10 or more prescriptions were 0.7 (95% CI 0.6–0.9) and 0.6 (95% CI 0.4–0.9), respectively. Similarly, reduced risk estimates were found for stomach (SIR 0.7, 95% CI 0.4–1.1) and ovarian cancer (SIR 0.7, 95% CI 0.4–1.0). Standardised incidence ratios for other cancers among those with 10 or more prescriptions tended to be close to 1.0, except for lung, kidney, and prostate cancers with SIRs of 1.3 (95% CI 1.1–1.6), 1.4 (95% CI 0.9–2.1), and 1.6 (95% CI 1.3–2.0), respectively. We found protective associations of NSAIDs against colon, rectal, stomach, and ovarian cancer. Reasons for the increased risk for some cancer sites are not clear.</description><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cohort Studies</subject><subject>Colorectal Neoplasms - prevention & control</subject><subject>Denmark - epidemiology</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - prevention & control</subject><subject>Oncology</subject><subject>Ovarian Neoplasms - prevention & control</subject><subject>Population Surveillance</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sørensen, H T</au><au>Friis, S</au><au>Nørgård, B</au><au>Mellemkjær, L</au><au>Blot, W J</au><au>McLaughlin, J K</au><au>Ekbom, A</au><au>Baron, J A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2003-06-02</date><risdate>2003</risdate><volume>88</volume><issue>11</issue><spage>1687</spage><epage>1692</epage><pages>1687-1692</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>There is increasing evidence of an inverse association between use of nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of colorectal cancer. However, data regarding other cancer sites are limited. Using data from the population-based North Jutland Prescription Database and the Danish Cancer Registry, we compared cancer incidence among 172 057 individuals prescribed nonaspirin NSAIDs with expected incidence (based on county-specific cancer rates) during a 9-year study period. A total of 6081 incident cancer cases were diagnosed among NSAID users
vs
5722 expected (standardised incidence ratio (SIR) 1.1, 95% confidence interval (CI)1.0–1.1). The SIRs for colon and rectal cancer among persons who obtained 10 or more prescriptions were 0.7 (95% CI 0.6–0.9) and 0.6 (95% CI 0.4–0.9), respectively. Similarly, reduced risk estimates were found for stomach (SIR 0.7, 95% CI 0.4–1.1) and ovarian cancer (SIR 0.7, 95% CI 0.4–1.0). Standardised incidence ratios for other cancers among those with 10 or more prescriptions tended to be close to 1.0, except for lung, kidney, and prostate cancers with SIRs of 1.3 (95% CI 1.1–1.6), 1.4 (95% CI 0.9–2.1), and 1.6 (95% CI 1.3–2.0), respectively. We found protective associations of NSAIDs against colon, rectal, stomach, and ovarian cancer. Reasons for the increased risk for some cancer sites are not clear.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>12771981</pmid><doi>10.1038/sj.bjc.6600945</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cohort Studies Colorectal Neoplasms - prevention & control Denmark - epidemiology Drug Resistance Epidemiology Female Humans Incidence Male Medical sciences Middle Aged Molecular Medicine Neoplasms - epidemiology Neoplasms - prevention & control Oncology Ovarian Neoplasms - prevention & control Population Surveillance Registries Risk Factors Stomach Neoplasms - prevention & control Tumors |
| title | Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study |
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