Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties
Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, predominantly expressed in hypothalamus, and recognized as a key regulator in feeding behaviour and energy balance. In this study, we examined the behavioural effects of intracerebroventricularly administered MCH on food intake, anxiety,...
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| Veröffentlicht in: | Regulatory peptides 2003-07, Vol.114 (2), p.109-114 |
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| creator | Kela, Johanna Salmi, Peter Rimondini-Giorgini, Roberto Heilig, Markus Wahlestedt, Claes |
| description | Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, predominantly expressed in hypothalamus, and recognized as a key regulator in feeding behaviour and energy balance. In this study, we examined the behavioural effects of intracerebroventricularly administered MCH on food intake, anxiety, exploratory behaviour and body core temperature in rats. MCH (0.15–10.0 μg, i.c.v.) acutely increased food intake in a dose-dependent manner. In addition, MCH (0.6–10.0 μg, i.c.v.) produced effects similar to anxiolytics in an animal model of anxiety, Vogel's punished drinking test. Thus, punished drinking episodes were significantly increased. We found no effects of MCH (5.0–20.0 μg, i.c.v.) on locomotor activity either in habituated or non-habituated animals. Furthermore, MCH did not produce any changes in body core temperature. Together, these observations further support a role for MCH as an orexigenic neuropeptide and also suggest anti-anxiety properties for MCH. |
| doi_str_mv | 10.1016/S0167-0115(03)00114-9 |
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In this study, we examined the behavioural effects of intracerebroventricularly administered MCH on food intake, anxiety, exploratory behaviour and body core temperature in rats. MCH (0.15–10.0 μg, i.c.v.) acutely increased food intake in a dose-dependent manner. In addition, MCH (0.6–10.0 μg, i.c.v.) produced effects similar to anxiolytics in an animal model of anxiety, Vogel's punished drinking test. Thus, punished drinking episodes were significantly increased. We found no effects of MCH (5.0–20.0 μg, i.c.v.) on locomotor activity either in habituated or non-habituated animals. Furthermore, MCH did not produce any changes in body core temperature. 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Urophysis ; Locomotor activity ; Male ; Medicin och hälsovetenskap ; Melanins - physiology ; Pituitary Hormones - physiology ; Rats ; Rats, Sprague-Dawley ; Thermoregulation ; Vertebrates: endocrinology</subject><ispartof>Regulatory peptides, 2003-07, Vol.114 (2), p.109-114</ispartof><rights>2003 Elsevier Science B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-ae73352c6cd1244c975fea0ba78295e20c1e22dd0bd4ecc818a6f7057118ca4e3</citedby><cites>FETCH-LOGICAL-c477t-ae73352c6cd1244c975fea0ba78295e20c1e22dd0bd4ecc818a6f7057118ca4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0167-0115(03)00114-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14938815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12832098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1961500$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kela, Johanna</creatorcontrib><creatorcontrib>Salmi, Peter</creatorcontrib><creatorcontrib>Rimondini-Giorgini, Roberto</creatorcontrib><creatorcontrib>Heilig, Markus</creatorcontrib><creatorcontrib>Wahlestedt, Claes</creatorcontrib><title>Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, predominantly expressed in hypothalamus, and recognized as a key regulator in feeding behaviour and energy balance. In this study, we examined the behavioural effects of intracerebroventricularly administered MCH on food intake, anxiety, exploratory behaviour and body core temperature in rats. MCH (0.15–10.0 μg, i.c.v.) acutely increased food intake in a dose-dependent manner. In addition, MCH (0.6–10.0 μg, i.c.v.) produced effects similar to anxiolytics in an animal model of anxiety, Vogel's punished drinking test. Thus, punished drinking episodes were significantly increased. We found no effects of MCH (5.0–20.0 μg, i.c.v.) on locomotor activity either in habituated or non-habituated animals. Furthermore, MCH did not produce any changes in body core temperature. Together, these observations further support a role for MCH as an orexigenic neuropeptide and also suggest anti-anxiety properties for MCH.</description><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - physiopathology</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Body temperature</subject><subject>Body Temperature - physiology</subject><subject>Exploratory behaviour</subject><subject>Food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamic Hormones - physiology</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Melanins - physiology</subject><subject>Pituitary Hormones - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Thermoregulation</subject><subject>Vertebrates: endocrinology</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhJ4ByAZVDwBPHscMF0YovqRIH4Gx57UlrSOxgJ0v33-N0Q_eEONgej553ZuyXkKdAXwGF5vXXvImSAvAzyl7SHNRle49sQApWQiOb-2Rzh5yQRyn9yBAXgj0kJ1BJVtFWbsh4jtd658IcdV9or_t9cqkIXTFgr73zpQneoJ-inpy_Kq5DHILHwvkiZ9KbAnfOYiaKLsQiRLxxV-idyaVsXjcu9PspX8cYRoyTw_SYPOh0n_DJep6S7x_ef7v4VF5--fj54t1laWohplKjYIxXpjEWqro2reAdarrVQlYtx4oawKqylm5tjcZIkLrpBOUCQBpdIzsl5aFu-o3jvFVjdIOOexW0U2vqZ45Qcdmymmde_JPP09uj6K8Q2gY4pVn54qDM2K8Z06QGlwz2-f8wzEkJVoMEWEB-AE0MKUXs7poAVYup6tZUtTimKFO3pqo2656tDebtgPaoWl3MwPMV0MnovovaG5eOXN0yKWF549sDh_njdw6jSsYt7lkX0UzKBvefUf4AZFvCPA</recordid><startdate>20030715</startdate><enddate>20030715</enddate><creator>Kela, Johanna</creator><creator>Salmi, Peter</creator><creator>Rimondini-Giorgini, Roberto</creator><creator>Heilig, Markus</creator><creator>Wahlestedt, Claes</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20030715</creationdate><title>Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties</title><author>Kela, Johanna ; Salmi, Peter ; Rimondini-Giorgini, Roberto ; Heilig, Markus ; Wahlestedt, Claes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-ae73352c6cd1244c975fea0ba78295e20c1e22dd0bd4ecc818a6f7057118ca4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - physiopathology</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Body temperature</topic><topic>Body Temperature - physiology</topic><topic>Exploratory behaviour</topic><topic>Food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamic Hormones - physiology</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Melanins - physiology</topic><topic>Pituitary Hormones - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Thermoregulation</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kela, Johanna</creatorcontrib><creatorcontrib>Salmi, Peter</creatorcontrib><creatorcontrib>Rimondini-Giorgini, Roberto</creatorcontrib><creatorcontrib>Heilig, Markus</creatorcontrib><creatorcontrib>Wahlestedt, Claes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kela, Johanna</au><au>Salmi, Peter</au><au>Rimondini-Giorgini, Roberto</au><au>Heilig, Markus</au><au>Wahlestedt, Claes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>2003-07-15</date><risdate>2003</risdate><volume>114</volume><issue>2</issue><spage>109</spage><epage>114</epage><pages>109-114</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, predominantly expressed in hypothalamus, and recognized as a key regulator in feeding behaviour and energy balance. In this study, we examined the behavioural effects of intracerebroventricularly administered MCH on food intake, anxiety, exploratory behaviour and body core temperature in rats. MCH (0.15–10.0 μg, i.c.v.) acutely increased food intake in a dose-dependent manner. In addition, MCH (0.6–10.0 μg, i.c.v.) produced effects similar to anxiolytics in an animal model of anxiety, Vogel's punished drinking test. Thus, punished drinking episodes were significantly increased. We found no effects of MCH (5.0–20.0 μg, i.c.v.) on locomotor activity either in habituated or non-habituated animals. Furthermore, MCH did not produce any changes in body core temperature. Together, these observations further support a role for MCH as an orexigenic neuropeptide and also suggest anti-anxiety properties for MCH.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12832098</pmid><doi>10.1016/S0167-0115(03)00114-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Anxiety Anxiety - physiopathology Behavior, Animal - physiology Biological and medical sciences Body temperature Body Temperature - physiology Exploratory behaviour Food intake Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamic Hormones - physiology Hypothalamus. Hypophysis. Epiphysis. Urophysis Locomotor activity Male Medicin och hälsovetenskap Melanins - physiology Pituitary Hormones - physiology Rats Rats, Sprague-Dawley Thermoregulation Vertebrates: endocrinology |
| title | Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties |
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