G-CSF given after haematopoietic stem cell transplantation using HLA-identical sibling donors is associated to a higher incidence of acute GVHD II-IV

The effect of granulocyte colony-stimulating factor (G-CSF), given after transplantation, was studied in 155 patients transplanted with haematopoietic stem cells (HSCT) from HLA-identical sibling donors at Huddinge University Hospital between 1993 and 2001. Only patients with haematological malignan...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2003-07, Vol.32 (2), p.217-223
Hauptverfasser:	REMBERGER, M, NASEH, N, ASCHAN, J, BARKHOLT, L, LEBLANC, K, SVENNBERG, P, RINGDEN, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Busulfan Care and treatment Child Child, Preschool Colony-stimulating factor Cyclosporins Donors Erythrocytes Female Graft Survival - drug effects Graft versus host disease Graft versus host reaction Graft vs Host Disease - chemically induced Graft vs Host Disease - mortality Graft vs Host Disease - pathology Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - adverse effects Granulocyte Colony-Stimulating Factor - therapeutic use Health aspects Hematologic Neoplasms - complications Hematologic Neoplasms - mortality Hematologic Neoplasms - therapy Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - mortality Hematopoietic stem cells Histocompatibility antigen HLA HLA Antigens Humans Incidence Infant Irradiation Leukocytes (granulocytic) Leukocytes (neutrophilic) Male Medical sciences Methods Methotrexate Middle Aged Mortality Multivariate analysis Patients Physiological aspects Prophylaxis Radiation Retrospective Studies Risk analysis Risk factors Siblings Stem cell transplantation Stem cells Survival Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Homologous Transplants & implants
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The effect of granulocyte colony-stimulating factor (G-CSF), given after transplantation, was studied in 155 patients transplanted with haematopoietic stem cells (HSCT) from HLA-identical sibling donors at Huddinge University Hospital between 1993 and 2001. Only patients with haematological malignancies were included. Conditioning consisted of total-body irradiation in 118 and busulphan in 37 patients. They were all given methotrexate combined with cyclosporine as graft-versus-host disease (GVHD) prophylaxis. Of the 155 patients, 66 (43%) received G-CSF after HSCT. Those given G-CSF had a significantly shorter time to neutrophil engraftment (P
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1704108