Area Specificity and Topography of Thalamocortical Projections Are Controlled by ephrin/Eph Genes

The mechanisms generating precise connections between specific thalamic nuclei and cortical areas remain poorly understood. Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2003-07, Vol.39 (3), p.453-465
Hauptverfasser:	Dufour, Audrey, Seibt, Julie, Passante, Lara, Depaepe, Vanessa, Ciossek, Thomas, Frisén, Jonas, Kullander, Klas, Flanagan, John G., Polleux, Franck, Vanderhaeghen, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Brain Mapping - methods Brain research Cell culture Cerebral Cortex - embryology Cerebral Cortex - enzymology Cerebral Cortex - metabolism Cerebral Cortex/embryology/enzymology/metabolism Ephrin-A4 - biosynthesis Ephrin-A4 - genetics Ephrin-A4 - physiology Ephrin-A4/biosynthesis/genetics/physiology Ephrin-A5 - biosynthesis Ephrin-A5 - genetics Ephrin-A5 - physiology Ephrin-A5/biosynthesis/genetics/physiology Female Ligands MEDICIN MEDICINE Mice Mice, Inbred C57BL Mice, Transgenic Neural Pathways - embryology Neural Pathways - enzymology Neural Pathways - metabolism Neural Pathways - physiology Neural Pathways/embryology/enzymology/metabolism/physiology Receptor, EphA4 - biosynthesis Receptor, EphA4 - genetics Receptor, EphA4 - physiology Receptor, EphA5 - biosynthesis Receptor, EphA5 - genetics Receptor, EphA5 - physiology Rodents Studies Thalamus - embryology Thalamus - enzymology Thalamus - metabolism Thalamus/embryology/enzymology/metabolism
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