Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice

The anticonvulsant drug gabapentin has been demonstrated to alleviate symptoms of painful diabetic neuropathy as well as other types of neuropathic pain. The aim of the present study was to investigate the effect of gabapentin in a recently developed mouse model of peripheral neuropathy. This model...

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Veröffentlicht in:	Experimental neurology 2003-08, Vol.182 (2), p.427-434
Hauptverfasser:	Gustafsson, Henrik, Flood, Karin, Berge, Odd-Geir, Brodin, Ernst, Olgart, Leif, Stiller, Carl-Olav
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - blood Acetates - pharmacology Allodynia Amines Analgesics - blood Analgesics - pharmacology Animals Behavior, Animal - drug effects Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Cyclohexanecarboxylic Acids Disease Models, Animal Erythrosine Formaldehyde Formalin Gabapentin gamma-Aminobutyric Acid Hindlimb - innervation Hindlimb - physiopathology Hyperalgesia - drug therapy Hyperalgesia - physiopathology Laser Lasers Light - adverse effects Male Medical sciences Mice Mice, Inbred Strains Motor Activity - drug effects Nervous system (semeiology, syndromes) Neurology Neuropathic pain Pain Measurement - drug effects Photochemistry Sciatic nerve Sciatic Nerve - drug effects Sciatic Nerve - radiation effects Sciatic Neuropathy - chemically induced Sciatic Neuropathy - drug therapy Sciatic Neuropathy - physiopathology Vascular diseases and vascular malformations of the nervous system Von Frey hair filaments
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