Invasive breast cancer: correlation of dynamic MR features with prognostic factors
The purpose of this exploratory study was to correlate kinetic and morphologic MR features with histologic prognostic factors in invasive breast cancer. Sixty-one women with invasive breast cancer underwent dynamic contrast-enhanced MR imaging at 1.5 T, using T1-weighted 3D fast low-angle shot techn...
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| Veröffentlicht in: | European radiology 2003-11, Vol.13 (11), p.2425-2435 |
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| creator | Szabó, Botond K Aspelin, Peter Kristoffersen Wiberg, Maria Tot, Tibor Boné, Beata |
| description | The purpose of this exploratory study was to correlate kinetic and morphologic MR features with histologic prognostic factors in invasive breast cancer. Sixty-one women with invasive breast cancer underwent dynamic contrast-enhanced MR imaging at 1.5 T, using T1-weighted 3D fast low-angle shot technique. The MR characteristics were correlated with classical pathologic prognostic factors (tumor size, histologic type, grade and lymph node status) and immunohistochemically detected biomarkers [c-erbB-2, p53, Ki-67, and estrogen receptor (ER)]. Univariate and multivariate statistical analyses were performed. Presence of rim enhancement pattern, early maximal enhancement and washout phenomenon were independently associated with established predictors of poor prognosis (higher histologic grade, positive Ki-67, and negative ER status). Our results suggest that these MR signs are not only important in differentiating benign from malignant lesions, but may also be useful to noninvasively identify highly aggressive breast carcinomas. |
| doi_str_mv | 10.1007/s00330-003-2000-y |
| format | Article |
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Sixty-one women with invasive breast cancer underwent dynamic contrast-enhanced MR imaging at 1.5 T, using T1-weighted 3D fast low-angle shot technique. The MR characteristics were correlated with classical pathologic prognostic factors (tumor size, histologic type, grade and lymph node status) and immunohistochemically detected biomarkers [c-erbB-2, p53, Ki-67, and estrogen receptor (ER)]. Univariate and multivariate statistical analyses were performed. Presence of rim enhancement pattern, early maximal enhancement and washout phenomenon were independently associated with established predictors of poor prognosis (higher histologic grade, positive Ki-67, and negative ER status). Our results suggest that these MR signs are not only important in differentiating benign from malignant lesions, but may also be useful to noninvasively identify highly aggressive breast carcinomas.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-003-2000-y</identifier><identifier>PMID: 12898176</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Aged ; Breast cancer ; Breast Neoplasms - pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Medicin och hälsovetenskap ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Prognosis ; Tumors</subject><ispartof>European radiology, 2003-11, Vol.13 (11), p.2425-2435</ispartof><rights>Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-f3a5a4847561feb84646bba9b87a24b73bf422202e3b418adeccfaa7554050483</citedby><cites>FETCH-LOGICAL-c410t-f3a5a4847561feb84646bba9b87a24b73bf422202e3b418adeccfaa7554050483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12898176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1932133$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Szabó, Botond K</creatorcontrib><creatorcontrib>Aspelin, Peter</creatorcontrib><creatorcontrib>Kristoffersen Wiberg, Maria</creatorcontrib><creatorcontrib>Tot, Tibor</creatorcontrib><creatorcontrib>Boné, Beata</creatorcontrib><title>Invasive breast cancer: correlation of dynamic MR features with prognostic factors</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>The purpose of this exploratory study was to correlate kinetic and morphologic MR features with histologic prognostic factors in invasive breast cancer. 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Sixty-one women with invasive breast cancer underwent dynamic contrast-enhanced MR imaging at 1.5 T, using T1-weighted 3D fast low-angle shot technique. The MR characteristics were correlated with classical pathologic prognostic factors (tumor size, histologic type, grade and lymph node status) and immunohistochemically detected biomarkers [c-erbB-2, p53, Ki-67, and estrogen receptor (ER)]. Univariate and multivariate statistical analyses were performed. Presence of rim enhancement pattern, early maximal enhancement and washout phenomenon were independently associated with established predictors of poor prognosis (higher histologic grade, positive Ki-67, and negative ER status). 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| subjects | Adult Aged Breast cancer Breast Neoplasms - pathology Female Humans Magnetic Resonance Imaging Medicin och hälsovetenskap Middle Aged Multivariate Analysis Neoplasm Invasiveness Prognosis Tumors |
| title | Invasive breast cancer: correlation of dynamic MR features with prognostic factors |
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