Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays

Neurofibrillary degeneration has primary and pivotal involvement in the pathogenesis of Alzheimer disease (AD) and other tauopathies. The inhibition of this lesion offers a promising therapeutic approach. The microtubule- associated protein (MAP) tau is abnormally hyperphosphorylated in the brain of...

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Veröffentlicht in:	Journal of molecular neuroscience 2003, Vol.20 (3), p.425-429
Hauptverfasser:	Iqbal, Khalid, Alonso, Alejandra del C, El-Akkad, Ezzat, Gong, Cheng-Xin, Haque, Niloufar, Khatoon, Sabiha, Pei, Jin-Jing, Tanimukai, Hitoshi, Tsujio, Ichiro, Wang, Jian-Zhi, Grundke-Iqba, Inge
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Animals Drug Evaluation, Preclinical Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Medicin och hälsovetenskap Microtubules - metabolism Microtubules - pathology Neurofibrillary Tangles - drug effects Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Phosphoprotein Phosphatases - drug effects Phosphoprotein Phosphatases - metabolism Phosphorylation - drug effects tau Proteins - drug effects tau Proteins - metabolism
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