Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE)
Cosmic radiation is an occupational risk factor for commercial aircrews. In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and...
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| Veröffentlicht in: | Radiation and environmental biophysics 2004-02, Vol.42 (4), p.247-256 |
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| creator | Langner, I Blettner, M Gundestrup, M Storm, H Aspholm, R Auvinen, A Pukkala, E Hammer, G P Zeeb, H Hrafnkelsson, J Rafnsson, V Tulinius, H De Angelis, G Verdecchia, A Haldorsen, T Tveten, U Eliasch, H Hammar, N Linnersjö, A |
| description | Cosmic radiation is an occupational risk factor for commercial aircrews. In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and cumulative lifetime doses did not exceed 80 mSv. All-cause and all-cancer mortality was low for all exposure categories. A significant negative risk trend for all-cause mortality was seen with increasing dose. Neither external and internal comparisons nor nested case-control analyses showed any substantially increased risks for cancer mortality due to ionizing radiation. However, the number of deaths for specific types of cancer was low and the confidence intervals of the risk estimates were rather wide. Difficulties in interpreting mortality risk estimates for time-dependent exposures are discussed. |
| doi_str_mv | 10.1007/s00411-003-0214-7 |
| format | Article |
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In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and cumulative lifetime doses did not exceed 80 mSv. All-cause and all-cancer mortality was low for all exposure categories. A significant negative risk trend for all-cause mortality was seen with increasing dose. Neither external and internal comparisons nor nested case-control analyses showed any substantially increased risks for cancer mortality due to ionizing radiation. However, the number of deaths for specific types of cancer was low and the confidence intervals of the risk estimates were rather wide. Difficulties in interpreting mortality risk estimates for time-dependent exposures are discussed.</description><identifier>ISSN: 0301-634X</identifier><identifier>EISSN: 1432-2099</identifier><identifier>DOI: 10.1007/s00411-003-0214-7</identifier><identifier>PMID: 14648170</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Aerospace Medicine - statistics & numerical data ; Aircraft ; Cancer ; Case-Control Studies ; Cause of Death ; Cohort Studies ; Confidence intervals ; Cosmic Radiation - adverse effects ; Cosmic rays ; Europe - epidemiology ; Female ; Health risks ; Humans ; Ionizing radiation ; Male ; Middle Aged ; Mortality risk ; Neoplasms - epidemiology ; Neoplasms - etiology ; Neoplasms - mortality ; Neoplasms, Radiation-Induced - epidemiology ; Neoplasms, Radiation-Induced - etiology ; Neoplasms, Radiation-Induced - mortality ; Occupational Exposure - statistics & numerical data ; Pilots ; Poisson Distribution ; Radiometry ; Risk Assessment ; Risk factors</subject><ispartof>Radiation and environmental biophysics, 2004-02, Vol.42 (4), p.247-256</ispartof><rights>Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-a59b6611b2556649e846f068b1ca4af91930b06358b81d9fc0cbceebc6d4da1d3</citedby><cites>FETCH-LOGICAL-c462t-a59b6611b2556649e846f068b1ca4af91930b06358b81d9fc0cbceebc6d4da1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14648170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1932260$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Langner, I</creatorcontrib><creatorcontrib>Blettner, M</creatorcontrib><creatorcontrib>Gundestrup, M</creatorcontrib><creatorcontrib>Storm, H</creatorcontrib><creatorcontrib>Aspholm, R</creatorcontrib><creatorcontrib>Auvinen, A</creatorcontrib><creatorcontrib>Pukkala, E</creatorcontrib><creatorcontrib>Hammer, G P</creatorcontrib><creatorcontrib>Zeeb, H</creatorcontrib><creatorcontrib>Hrafnkelsson, J</creatorcontrib><creatorcontrib>Rafnsson, V</creatorcontrib><creatorcontrib>Tulinius, H</creatorcontrib><creatorcontrib>De Angelis, G</creatorcontrib><creatorcontrib>Verdecchia, A</creatorcontrib><creatorcontrib>Haldorsen, T</creatorcontrib><creatorcontrib>Tveten, U</creatorcontrib><creatorcontrib>Eliasch, H</creatorcontrib><creatorcontrib>Hammar, N</creatorcontrib><creatorcontrib>Linnersjö, A</creatorcontrib><title>Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE)</title><title>Radiation and environmental biophysics</title><addtitle>Radiat Environ Biophys</addtitle><description>Cosmic radiation is an occupational risk factor for commercial aircrews. In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and cumulative lifetime doses did not exceed 80 mSv. All-cause and all-cancer mortality was low for all exposure categories. A significant negative risk trend for all-cause mortality was seen with increasing dose. Neither external and internal comparisons nor nested case-control analyses showed any substantially increased risks for cancer mortality due to ionizing radiation. However, the number of deaths for specific types of cancer was low and the confidence intervals of the risk estimates were rather wide. Difficulties in interpreting mortality risk estimates for time-dependent exposures are discussed.</description><subject>Adult</subject><subject>Aerospace Medicine - statistics & numerical data</subject><subject>Aircraft</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Cause of Death</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Cosmic Radiation - adverse effects</subject><subject>Cosmic rays</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Health risks</subject><subject>Humans</subject><subject>Ionizing radiation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality risk</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms, Radiation-Induced - epidemiology</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Neoplasms, Radiation-Induced - mortality</subject><subject>Occupational Exposure - statistics & numerical data</subject><subject>Pilots</subject><subject>Poisson Distribution</subject><subject>Radiometry</subject><subject>Risk Assessment</subject><subject>Risk 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| subjects | Adult Aerospace Medicine - statistics & numerical data Aircraft Cancer Case-Control Studies Cause of Death Cohort Studies Confidence intervals Cosmic Radiation - adverse effects Cosmic rays Europe - epidemiology Female Health risks Humans Ionizing radiation Male Middle Aged Mortality risk Neoplasms - epidemiology Neoplasms - etiology Neoplasms - mortality Neoplasms, Radiation-Induced - epidemiology Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - mortality Occupational Exposure - statistics & numerical data Pilots Poisson Distribution Radiometry Risk Assessment Risk factors |
| title | Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE) |
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