No Evidence for Linkage in Swedish Multiplex T1DM Families to IL12B on Chromosome 5q33-34

: Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the β cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ‐specific autoimmune diseases. In NOD mi...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2003-11, Vol.1005 (1), p.352-355
Hauptverfasser:	HOLM, PERNILLA, LUTHMAN, HOLGER, KOCKUM, INGRID
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes, Human, Pair 5 Clinical Medicine Diabetes Mellitus, Type 1 - genetics Endocrinology and Diabetes Endokrinologi och diabetes Genetic Linkage Humans IL12 IL12B Interleukin-12 - genetics Klinisk medicin linkage Medical and Health Sciences Medicin och hälsovetenskap Sweden test (TDT) transmission distortion transmission distortion test (TDT) type 1 diabetes mellitus (T1DM)
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container_title	Annals of the New York Academy of Sciences
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creator	HOLM, PERNILLA LUTHMAN, HOLGER KOCKUM, INGRID
description	: Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the β cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ‐specific autoimmune diseases. In NOD mice, administration of IL12 induces T1DM and administration of IL12 antagonists prevents T1DM. Linkage and association of IL12 to T1DM have been reported previously. We are unable to replicate this linkage on chromosome 5q33‐34 in 184 Swedish families. Further, we exclude a gene with λs > 1.4 from this region. Together with previously published findings, these data make IL12 an unlikely major susceptibility gene for T1DM.
doi_str_mv	10.1196/annals.1288.057
format	Article
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IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ‐specific autoimmune diseases. In NOD mice, administration of IL12 induces T1DM and administration of IL12 antagonists prevents T1DM. Linkage and association of IL12 to T1DM have been reported previously. We are unable to replicate this linkage on chromosome 5q33‐34 in 184 Swedish families. Further, we exclude a gene with λs > 1.4 from this region. 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IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ‐specific autoimmune diseases. In NOD mice, administration of IL12 induces T1DM and administration of IL12 antagonists prevents T1DM. Linkage and association of IL12 to T1DM have been reported previously. We are unable to replicate this linkage on chromosome 5q33‐34 in 184 Swedish families. Further, we exclude a gene with λs > 1.4 from this region. Together with previously published findings, these data make IL12 an unlikely major susceptibility gene for T1DM.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14679090</pmid><doi>10.1196/annals.1288.057</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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subjects	Chromosomes, Human, Pair 5 Clinical Medicine Diabetes Mellitus, Type 1 - genetics Endocrinology and Diabetes Endokrinologi och diabetes Genetic Linkage Humans IL12 IL12B Interleukin-12 - genetics Klinisk medicin linkage Medical and Health Sciences Medicin och hälsovetenskap Sweden test (TDT) transmission distortion transmission distortion test (TDT) type 1 diabetes mellitus (T1DM)
title	No Evidence for Linkage in Swedish Multiplex T1DM Families to IL12B on Chromosome 5q33-34
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