Increased levels of insulin and insulin-like growth factor-1 hybrid receptors and decreased glycosylation of the insulin receptor alpha- and beta-subunits in scrapie-infected neuroblastoma N2a cells

We have previously shown that ScN2a cells (scrapie-infected neuroblastoma N2a cells) express 2-fold- and 4-fold-increased levels of IR (insulin receptor) and IGF-1R (insulin-like growth factor-1 receptor) respectively. In addition, the IR alpha- and beta-subunits are aberrantly processed, with appar...

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Veröffentlicht in:	Biochemical journal 2004-06, Vol.380 (Pt 2), p.571-579
Hauptverfasser:	Nielsen, Daniel, Gyllberg, Hanna, Ostlund, Pernilla, Bergman, Tomas, Bedecs, Katarina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - genetics Cell Line, Tumor Electrophoretic Mobility Shift Assay - methods Glycosylation Insulin - metabolism Medicin och hälsovetenskap Mice Molecular Weight Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neuroblastoma - chemistry Neuroblastoma - metabolism Neuroblastoma - pathology Protein Binding - genetics Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism PrPSc Proteins - metabolism PrPSc Proteins - pathogenicity Receptor, IGF Type 1 - chemistry Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Receptor, Insulin - chemistry Receptor, Insulin - genetics Receptor, Insulin - metabolism Recombination, Genetic - genetics Recombination, Genetic - physiology Scrapie - genetics Scrapie - metabolism Scrapie - pathology
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