Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site

The PTCH1 tumor suppressor gene encodes a receptor for secreted hedgehog (HH) ligands and is important for proper proliferation, differentiation and patterning in almost every tissue and organ during embryogenesis. The PTCH1 protein works as a negative regulator of the HH-signaling pathway by repres...

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Veröffentlicht in:	Gene 2004-04, Vol.330, p.101-114
Hauptverfasser:	Ågren, Marie, Kogerman, Priit, Kleman, Marika I., Wessling, Martina, Toftgård, Rune
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 5' Flanking Region - genetics Animals Base Sequence Binding Sites - genetics Cell Line Electrophoretic Mobility Shift Assay Gene Expression Regulation Genes, Tumor Suppressor GLI1 Gli2 GLI3 Green Fluorescent Proteins Hedgehog Proteins HH signaling pathway Humans Intracellular Signaling Peptides and Proteins Luciferases - genetics Luciferases - metabolism Luminescent Proteins - genetics Luminescent Proteins - metabolism Medicin och hälsovetenskap Membrane Proteins - genetics Mice Molecular Sequence Data Mutagenesis, Site-Directed Mutation Oncogene Proteins - genetics Oncogene Proteins - metabolism Patched Receptors Patched-1 Receptor Promoter Regions, Genetic - genetics Protein Binding Receptors, Cell Surface Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Response Elements - genetics Signal Transduction Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transfection Zinc Finger Protein GLI1
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