Regulation of Regional Lung Perfusion by Nitric Oxide
Improved oxygenation has previously been shown in patients with acute lung injury when ventilated in prone position. We hypothesized that this was due to higher regional production of nitric oxide in dorsocaudal lung regions. We measured nitric oxide synthase mRNA expression and nitric oxide product...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2004-08, Vol.170 (4), p.450-455 |
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| creator | Rimeika, Danguole Nyren, Sven Wiklund, N. Peter Koskela, Lotta Renstrom Torring, Anders Gustafsson, Lars E Larsson, Stig A Jacobsson, Hans Lindahl, Sten G. E Wiklund, Claes U |
| description | Improved oxygenation has previously been shown in patients with acute lung injury when ventilated in prone position. We hypothesized that this was due to higher regional production of nitric oxide in dorsocaudal lung regions. We measured nitric oxide synthase mRNA expression and nitric oxide production by citrulline assay in ventral and dorsal lung tissue from patients. In volunteers, regional lung perfusion in prone and supine postures was assessed by single photon emission computed tomography using (99m)Tc macroaggregated albumin before and after inhibition of nitric oxide synthase by N(G)-monomethyl-L-arginine infusion. Nitric oxide synthase mRNA expression and nitric oxide production were significantly higher in dorsal compared with ventral lung regions. In supine posture, lung perfusion was shifted to ventral parts during nitric oxide synthase inhibition, whereas in the prone posture lung perfusion remained unchanged. Our results suggest a role for endogenous nitric oxide in regulation of regional pulmonary perfusion. |
| doi_str_mv | 10.1164/rccm.200312-1663OC |
| format | Article |
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Peter ; Koskela, Lotta Renstrom ; Torring, Anders ; Gustafsson, Lars E ; Larsson, Stig A ; Jacobsson, Hans ; Lindahl, Sten G. E ; Wiklund, Claes U</creator><creatorcontrib>Rimeika, Danguole ; Nyren, Sven ; Wiklund, N. Peter ; Koskela, Lotta Renstrom ; Torring, Anders ; Gustafsson, Lars E ; Larsson, Stig A ; Jacobsson, Hans ; Lindahl, Sten G. E ; Wiklund, Claes U</creatorcontrib><description>Improved oxygenation has previously been shown in patients with acute lung injury when ventilated in prone position. We hypothesized that this was due to higher regional production of nitric oxide in dorsocaudal lung regions. We measured nitric oxide synthase mRNA expression and nitric oxide production by citrulline assay in ventral and dorsal lung tissue from patients. In volunteers, regional lung perfusion in prone and supine postures was assessed by single photon emission computed tomography using (99m)Tc macroaggregated albumin before and after inhibition of nitric oxide synthase by N(G)-monomethyl-L-arginine infusion. Nitric oxide synthase mRNA expression and nitric oxide production were significantly higher in dorsal compared with ventral lung regions. In supine posture, lung perfusion was shifted to ventral parts during nitric oxide synthase inhibition, whereas in the prone posture lung perfusion remained unchanged. Our results suggest a role for endogenous nitric oxide in regulation of regional pulmonary perfusion.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200312-1663OC</identifier><identifier>PMID: 15130909</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Acid-Base Equilibrium - drug effects ; Acid-Base Equilibrium - physiology ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Heart Rate - drug effects ; Heart Rate - physiology ; Humans ; Intensive care medicine ; Lung - diagnostic imaging ; Lung - pathology ; Medical sciences ; Medicin och hälsovetenskap ; Nitric Oxide - biosynthesis ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase - metabolism ; omega-N-Methylarginine - pharmacology ; Posture - physiology ; Pulmonary Circulation - drug effects ; Pulmonary Circulation - physiology ; Radionuclide Imaging ; Tissue Distribution</subject><ispartof>American journal of respiratory and critical care medicine, 2004-08, Vol.170 (4), p.450-455</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Thoracic Society Aug 15, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-2b41b8cb1d41d369fd230cb3c30dc59f30d75c200159932a0f11715a3dc9f04f3</citedby><cites>FETCH-LOGICAL-c476t-2b41b8cb1d41d369fd230cb3c30dc59f30d75c200159932a0f11715a3dc9f04f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4025,4026,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16001126$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15130909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1935053$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Rimeika, Danguole</creatorcontrib><creatorcontrib>Nyren, Sven</creatorcontrib><creatorcontrib>Wiklund, N. Peter</creatorcontrib><creatorcontrib>Koskela, Lotta Renstrom</creatorcontrib><creatorcontrib>Torring, Anders</creatorcontrib><creatorcontrib>Gustafsson, Lars E</creatorcontrib><creatorcontrib>Larsson, Stig A</creatorcontrib><creatorcontrib>Jacobsson, Hans</creatorcontrib><creatorcontrib>Lindahl, Sten G. E</creatorcontrib><creatorcontrib>Wiklund, Claes U</creatorcontrib><title>Regulation of Regional Lung Perfusion by Nitric Oxide</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Improved oxygenation has previously been shown in patients with acute lung injury when ventilated in prone position. We hypothesized that this was due to higher regional production of nitric oxide in dorsocaudal lung regions. We measured nitric oxide synthase mRNA expression and nitric oxide production by citrulline assay in ventral and dorsal lung tissue from patients. In volunteers, regional lung perfusion in prone and supine postures was assessed by single photon emission computed tomography using (99m)Tc macroaggregated albumin before and after inhibition of nitric oxide synthase by N(G)-monomethyl-L-arginine infusion. Nitric oxide synthase mRNA expression and nitric oxide production were significantly higher in dorsal compared with ventral lung regions. In supine posture, lung perfusion was shifted to ventral parts during nitric oxide synthase inhibition, whereas in the prone posture lung perfusion remained unchanged. Our results suggest a role for endogenous nitric oxide in regulation of regional pulmonary perfusion.</description><subject>Acid-Base Equilibrium - drug effects</subject><subject>Acid-Base Equilibrium - physiology</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. 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| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2004-08, Vol.170 (4), p.450-455 |
| issn | 1073-449X 1535-4970 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_585603 |
| source | MEDLINE; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Acid-Base Equilibrium - drug effects Acid-Base Equilibrium - physiology Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Heart Rate - drug effects Heart Rate - physiology Humans Intensive care medicine Lung - diagnostic imaging Lung - pathology Medical sciences Medicin och hälsovetenskap Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism omega-N-Methylarginine - pharmacology Posture - physiology Pulmonary Circulation - drug effects Pulmonary Circulation - physiology Radionuclide Imaging Tissue Distribution |
| title | Regulation of Regional Lung Perfusion by Nitric Oxide |
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