Estrogen Up-Regulates Hepatic Expression of Suppressors of Cytokine Signaling-2 and -3 in Vivo and in Vitro

Suppressors of cytokine signaling (SOCS) are important negative regulators of cytokine action. We recently reported that estrogen stimulates SOCS-2 expression and inhibits GH signaling in kidney cells. The effects of estrogen on SOCS expression in other tissues are unclear. The aim of this study was...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2004-12, Vol.145 (12), p.5525-5531
Hauptverfasser:	Leong, Gary M, Moverare, Sofia, Brce, Jesena, Doyle, Nathan, Sjögren, Klara, Dahlman-Wright, Karin, Gustafsson, Jan-Åke, Ho, Ken K. Y, Ohlsson, Claes, Leung, Kin-Chuen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinoma Carcinoma, Hepatocellular Cell Line Cell Line, Tumor Cytokines DNA chips DNA microarrays DNA-Binding Proteins DNA-Binding Proteins - genetics drug effects Estradiol Estradiol - pharmacology Estrogen Receptor alpha Estrogen Receptor alpha - genetics Estrogen Receptor beta Estrogen Receptor beta - genetics Estrogen receptors Estrogens Female Fundamental and applied biological sciences. Psychology Gene expression Gene regulation genetics Growth Hormone Growth Hormone - pharmacology Hepatocellular Hepatocytes Hepatoma Humans In Vitro Techniques In vivo methods and tests Inbred C57BL Knockout Liver Liver - physiology Liver Neoplasms Medical and Health Sciences Medicin och hälsovetenskap Mice Mice, Inbred C57BL Mice, Knockout Nucleotides Ovariectomy pharmacology physiology Promoter Regions (Genetics) Promoter Regions, Genetic - physiology Repressor Proteins Repressor Proteins - genetics Reverse transcription Signal Transduction Signal Transduction - drug effects Signal Transduction - physiology Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Suppressors Trans-Activators Trans-Activators - genetics Transcription activation Transcription Factors Transcription Factors - genetics Tumor Up-Regulation Up-Regulation - drug effects Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!