Effect of combined T- and B-cell depletion of allogeneic HLA-mismatched bone marrow graft on the magnitude and kinetics of Epstein-Barr virus load in the peripheral blood of bone marrow transplant recipients
: Recipients of T‐cell‐depleted bone marrow (BM) transplants (BMT) frequently develop Epstein–Barr virus (EBV)‐associated post‐transplant lymphoproliferative disease (PTLD) preceded by a rapid and prominent increase of EBV load in the peripheral blood. The level of this increase positively correlat...
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| Veröffentlicht in: | Clinical transplantation 2004-10, Vol.18 (5), p.518-524 |
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| creator | Liu, Daorong Tammik, Charlotte Zou, Jie-Zhi Ernberg, Ingemar Masucci, Maria G. Ringden, Olle Levitsky, Victor |
| description | : Recipients of T‐cell‐depleted bone marrow (BM) transplants (BMT) frequently develop Epstein–Barr virus (EBV)‐associated post‐transplant lymphoproliferative disease (PTLD) preceded by a rapid and prominent increase of EBV load in the peripheral blood. The level of this increase positively correlates with the incidence of PTLD. Using a semiquantitative PCR assay we compared the blood levels of EBV‐DNA in patients transplanted with either T‐cell or T‐ and B‐cell‐depleted human leukocyte antigen (HLA)‐mismatched BM grafts. Combined T‐ and B‐cell depletion correlated with significantly lower maximal levels of EBV load, which were reached with slower kinetics. These data indicate that B‐cell depletion of BM can be used for prophylaxis of PTLD in BM transplant recipients and can affect the long‐term balance between EBV and its host. |
| doi_str_mv | 10.1111/j.1399-0012.2004.00198.x |
| format | Article |
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The level of this increase positively correlates with the incidence of PTLD. Using a semiquantitative PCR assay we compared the blood levels of EBV‐DNA in patients transplanted with either T‐cell or T‐ and B‐cell‐depleted human leukocyte antigen (HLA)‐mismatched BM grafts. Combined T‐ and B‐cell depletion correlated with significantly lower maximal levels of EBV load, which were reached with slower kinetics. These data indicate that B‐cell depletion of BM can be used for prophylaxis of PTLD in BM transplant recipients and can affect the long‐term balance between EBV and its host.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/j.1399-0012.2004.00198.x</identifier><identifier>PMID: 15344953</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Acute Disease ; Adolescent ; Adult ; B-cell ; B-Lymphocytes - pathology ; Biological and medical sciences ; Bone Marrow Transplantation - pathology ; Cardiology. Vascular system ; Child, Preschool ; Epstein-Barr virus ; Epstein-Barr Virus Infections - prevention & control ; Female ; Follow-Up Studies ; General aspects ; Hematologic and hematopoietic diseases ; Herpesvirus 4, Human - isolation & purification ; Herpesvirus 4, Human - physiology ; Histocompatibility - immunology ; HLA Antigens - immunology ; Humans ; Leukemia, Myeloid - therapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocyte Reduction Procedures - methods ; lymphoma ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; T-Lymphocytes - pathology ; Transplantation Conditioning ; Transplantation, Homologous ; Viral Load ; Viremia - virology</subject><ispartof>Clinical transplantation, 2004-10, Vol.18 (5), p.518-524</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5208-6fc08da7689c12d145804851424a52dbe31222759dd903faa7bc32ccaaa3f7c03</citedby><cites>FETCH-LOGICAL-c5208-6fc08da7689c12d145804851424a52dbe31222759dd903faa7bc32ccaaa3f7c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-0012.2004.00198.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-0012.2004.00198.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16100458$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15344953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:110460261$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Daorong</creatorcontrib><creatorcontrib>Tammik, Charlotte</creatorcontrib><creatorcontrib>Zou, Jie-Zhi</creatorcontrib><creatorcontrib>Ernberg, Ingemar</creatorcontrib><creatorcontrib>Masucci, Maria G.</creatorcontrib><creatorcontrib>Ringden, Olle</creatorcontrib><creatorcontrib>Levitsky, Victor</creatorcontrib><title>Effect of combined T- and B-cell depletion of allogeneic HLA-mismatched bone marrow graft on the magnitude and kinetics of Epstein-Barr virus load in the peripheral blood of bone marrow transplant recipients</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>: Recipients of T‐cell‐depleted bone marrow (BM) transplants (BMT) frequently develop Epstein–Barr virus (EBV)‐associated post‐transplant lymphoproliferative disease (PTLD) preceded by a rapid and prominent increase of EBV load in the peripheral blood. The level of this increase positively correlates with the incidence of PTLD. Using a semiquantitative PCR assay we compared the blood levels of EBV‐DNA in patients transplanted with either T‐cell or T‐ and B‐cell‐depleted human leukocyte antigen (HLA)‐mismatched BM grafts. Combined T‐ and B‐cell depletion correlated with significantly lower maximal levels of EBV load, which were reached with slower kinetics. These data indicate that B‐cell depletion of BM can be used for prophylaxis of PTLD in BM transplant recipients and can affect the long‐term balance between EBV and its host.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>B-cell</subject><subject>B-Lymphocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation - pathology</subject><subject>Cardiology. Vascular system</subject><subject>Child, Preschool</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - prevention & control</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Herpesvirus 4, Human - physiology</subject><subject>Histocompatibility - immunology</subject><subject>HLA Antigens - immunology</subject><subject>Humans</subject><subject>Leukemia, Myeloid - therapy</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocyte Reduction Procedures - methods</subject><subject>lymphoma</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>T-Lymphocytes - pathology</subject><subject>Transplantation Conditioning</subject><subject>Transplantation, Homologous</subject><subject>Viral Load</subject><subject>Viremia - virology</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks2O0zAUhSMEYkrhFZA3sEuxnTg_EpuZUmZAHUCoaJaWYzutW9fO2A7tPCWvhDMtLRskssnV9fnOta5PkgAEJyh-79YTlNV1CiHCEwxhPolVXU32T5LR6eBpMoI1xLEusovkhffr2C1QQZ4nF4hkeV6TbJT8mrWt5AHYFnC7bZSRAixSwIwAVymXWgMhOy2DsmbQMK3tUhqpOLiZX6Zb5bcs8FWEGmsk2DLn7A4sHWujpQFhNfSWRoVeyEfTTZwQFPeD2azzQSqTXkUK_FSu90BbJoA6gJ10qltJxzRotLViQP6eEhwzvtPMBOAkV52SJviXybOWaS9fHf_j5MfH2WJ6k86_Xn-aXs5TTjCs0qLlsBKsLKqaIyxQTiqYVwTlOGcEi0ZmCGNcklqIGmYtY2XDM8w5YyxrSw6zcZIefP1Odn1DO6fitR6oZYoeW5tYSUqqHJV11Nf_1HfOijP0B0QI5gXEBYrs2wMbhfe99IHGvQ9vw4y0vadFUeUExeccJ9VByJ313sn2NAZBOgSHrumQDzrkgw7BoY_BofuIvj7O6JutFGfwmJQoeHMUMM-ZbuPyufJnXYGiHami7v1Bt1NaPvz3Beh08T0W572qmI39CWduQ4syKwm9-3JN0efb228f8ju6yH4DQg7yHg</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Liu, Daorong</creator><creator>Tammik, Charlotte</creator><creator>Zou, Jie-Zhi</creator><creator>Ernberg, Ingemar</creator><creator>Masucci, Maria G.</creator><creator>Ringden, Olle</creator><creator>Levitsky, Victor</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>200410</creationdate><title>Effect of combined T- and B-cell depletion of allogeneic HLA-mismatched bone marrow graft on the magnitude and kinetics of Epstein-Barr virus load in the peripheral blood of bone marrow transplant recipients</title><author>Liu, Daorong ; Tammik, Charlotte ; Zou, Jie-Zhi ; Ernberg, Ingemar ; Masucci, Maria G. ; Ringden, Olle ; Levitsky, Victor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5208-6fc08da7689c12d145804851424a52dbe31222759dd903faa7bc32ccaaa3f7c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>B-cell</topic><topic>B-Lymphocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation - pathology</topic><topic>Cardiology. Vascular system</topic><topic>Child, Preschool</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - prevention & control</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Herpesvirus 4, Human - physiology</topic><topic>Histocompatibility - immunology</topic><topic>HLA Antigens - immunology</topic><topic>Humans</topic><topic>Leukemia, Myeloid - therapy</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukocyte Reduction Procedures - methods</topic><topic>lymphoma</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>T-Lymphocytes - pathology</topic><topic>Transplantation Conditioning</topic><topic>Transplantation, Homologous</topic><topic>Viral Load</topic><topic>Viremia - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Daorong</creatorcontrib><creatorcontrib>Tammik, Charlotte</creatorcontrib><creatorcontrib>Zou, Jie-Zhi</creatorcontrib><creatorcontrib>Ernberg, Ingemar</creatorcontrib><creatorcontrib>Masucci, Maria G.</creatorcontrib><creatorcontrib>Ringden, Olle</creatorcontrib><creatorcontrib>Levitsky, Victor</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Daorong</au><au>Tammik, Charlotte</au><au>Zou, Jie-Zhi</au><au>Ernberg, Ingemar</au><au>Masucci, Maria G.</au><au>Ringden, Olle</au><au>Levitsky, Victor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of combined T- and B-cell depletion of allogeneic HLA-mismatched bone marrow graft on the magnitude and kinetics of Epstein-Barr virus load in the peripheral blood of bone marrow transplant recipients</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2004-10</date><risdate>2004</risdate><volume>18</volume><issue>5</issue><spage>518</spage><epage>524</epage><pages>518-524</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>: Recipients of T‐cell‐depleted bone marrow (BM) transplants (BMT) frequently develop Epstein–Barr virus (EBV)‐associated post‐transplant lymphoproliferative disease (PTLD) preceded by a rapid and prominent increase of EBV load in the peripheral blood. The level of this increase positively correlates with the incidence of PTLD. Using a semiquantitative PCR assay we compared the blood levels of EBV‐DNA in patients transplanted with either T‐cell or T‐ and B‐cell‐depleted human leukocyte antigen (HLA)‐mismatched BM grafts. Combined T‐ and B‐cell depletion correlated with significantly lower maximal levels of EBV load, which were reached with slower kinetics. These data indicate that B‐cell depletion of BM can be used for prophylaxis of PTLD in BM transplant recipients and can affect the long‐term balance between EBV and its host.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>15344953</pmid><doi>10.1111/j.1399-0012.2004.00198.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute Disease Adolescent Adult B-cell B-Lymphocytes - pathology Biological and medical sciences Bone Marrow Transplantation - pathology Cardiology. Vascular system Child, Preschool Epstein-Barr virus Epstein-Barr Virus Infections - prevention & control Female Follow-Up Studies General aspects Hematologic and hematopoietic diseases Herpesvirus 4, Human - isolation & purification Herpesvirus 4, Human - physiology Histocompatibility - immunology HLA Antigens - immunology Humans Leukemia, Myeloid - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Reduction Procedures - methods lymphoma Male Medical sciences Medicin och hälsovetenskap Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy T-Lymphocytes - pathology Transplantation Conditioning Transplantation, Homologous Viral Load Viremia - virology |
| title | Effect of combined T- and B-cell depletion of allogeneic HLA-mismatched bone marrow graft on the magnitude and kinetics of Epstein-Barr virus load in the peripheral blood of bone marrow transplant recipients |
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