Overexpression of 11β-Hydroxysteroid Dehydrogenase-1 in Adipose Tissue Is Associated with Acquired Obesity and Features of Insulin Resistance: Studies in Young Adult Monozygotic Twins

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD-1) catalyzes the interconversion of inactive cortisone to active cortisol. Overexpression of 11β-HSD-1 in murine adipose tissue results in glucocorticoid receptor (GR)α overexpression, central obesity, and insulin resistance. It is controversial wheth...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2004-09, Vol.89 (9), p.4414-4421
Hauptverfasser:	Kannisto, Katja, Pietiläinen, Kirsi H., Ehrenborg, Ewa, Rissanen, Aila, Kaprio, Jaakko, Hamsten, Anders, Yki-Järvinen, Hannele
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Endocrinopathies Fundamental and applied biological sciences. Psychology Medical sciences Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!