Active immunization against nicotine alters the distribution of nicotine but not the metabolism to cotinine in the rat

We have previously shown that active immunization with the nicotine immunoconjugate IP18-KLH attenuates the reinforcing effects of nicotine, i.e., suppresses the nicotine-induced brain dopamine release and prevents reinstatement of the nicotine-seeking behavior in rats. These effects are thought to...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2004-10, Vol.370 (4), p.299-304
Hauptverfasser:	de Villiers, Sabina H L, Lindblom, Nina, Kalayanov, Genadiy, Gordon, Sandra, Johansson, Anette M, Svensson, Torgny H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - immunology Brain - metabolism Cotinine - metabolism Immunoconjugates - administration & dosage Immunoconjugates - immunology Male Medicin och hälsovetenskap Nicotine - administration & dosage Nicotine - immunology Nicotine - metabolism Rats Rats, Wistar Vaccination - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!