Interleukin‐1β and TNF‐α Act in Synergy to Inhibit Longitudinal Growth in Fetal Rat Metatarsal Bones

We hypothesized that pro‐inflammatory cytokines can act locally in the growth plate to impair longitudinal growth. In a model of cultured fetal rat metatarsal bones, we found that IL‐1β and TNF‐α act in synergy to inhibit longitudinal growth, an effect linked to decreased proliferation and increased...

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Veröffentlicht in:	Journal of bone and mineral research 2004-11, Vol.19 (11), p.1805-1812
Hauptverfasser:	Mårtensson, Katarina, Chrysis, Dionisios, Sävendahl, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences chondrocytes Fundamental and applied biological sciences. Psychology growth plate insulin‐like growth factor I interleukin‐1 Skeleton and joints TNF Vertebrates: osteoarticular system, musculoskeletal system
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