The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones
Kainate receptors (KARs) play an important role in synaptic physiology, plasticity and pathological phenomena such as epilepsy. However, the physiological implications for single cells and neuronal networks of the distinct expression patterns of KAR subunits are unknown. One intriguing effect of KAR...
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| Veröffentlicht in: | The Journal of physiology 2005-01, Vol.562 (1), p.199-203 |
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| creator | Fisahn, André Heinemann, Stephen F. McBain, Chris J. |
| description | Kainate receptors (KARs) play an important role in synaptic physiology, plasticity and pathological phenomena such as epilepsy.
However, the physiological implications for single cells and neuronal networks of the distinct expression patterns of KAR
subunits are unknown. One intriguing effect of KAR activation is a long-term change to intrinsic neuronal excitability and
neuronal firing patterns, such as single-spike and spike-burst firing. In this study, we describe the role of kainate receptor
subunits in the metabotropic regulation of the slow and medium afterhyperpolarization (AHP) currents ( I sAHP , I mAHP ). Using whole-cell patch-clamp recordings from CA3 pyramidal cells of wild-type (WT) and KAR knockout mice, we show that
the kainate-induced decrease of I sAHP and I mAHP amplitude is protein-kinase-C-dependent and absent in GluR6 â/â but not GluR5 â/â pyramidal neurones. Our findings suggest that activation of GluR6-containing KARs modulates AHP amplitude, and influences
the firing frequency of pyramidal neurones. |
| doi_str_mv | 10.1113/jphysiol.2004.077412 |
| format | Article |
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However, the physiological implications for single cells and neuronal networks of the distinct expression patterns of KAR
subunits are unknown. One intriguing effect of KAR activation is a long-term change to intrinsic neuronal excitability and
neuronal firing patterns, such as single-spike and spike-burst firing. In this study, we describe the role of kainate receptor
subunits in the metabotropic regulation of the slow and medium afterhyperpolarization (AHP) currents ( I sAHP , I mAHP ). Using whole-cell patch-clamp recordings from CA3 pyramidal cells of wild-type (WT) and KAR knockout mice, we show that
the kainate-induced decrease of I sAHP and I mAHP amplitude is protein-kinase-C-dependent and absent in GluR6 â/â but not GluR5 â/â pyramidal neurones. Our findings suggest that activation of GluR6-containing KARs modulates AHP amplitude, and influences
the firing frequency of pyramidal neurones.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.2004.077412</identifier><identifier>PMID: 15539395</identifier><language>eng</language><publisher>9600 Garsington Road , Oxford , OX4 2DQ , UK: The Physiological Society</publisher><subject>Action Potentials - physiology ; Animals ; Electrophysiology ; Excitatory Amino Acid Agonists - pharmacology ; GluK2 Kainate Receptor ; Hippocampus - cytology ; Hippocampus - physiology ; In Vitro Techniques ; Kainic Acid - pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Patch-Clamp Techniques ; Pyramidal Cells - physiology ; Receptors, Kainic Acid - genetics ; Receptors, Kainic Acid - physiology</subject><ispartof>The Journal of physiology, 2005-01, Vol.562 (1), p.199-203</ispartof><rights>2005 The Journal of Physiology © 2005 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5675-6ec7c5b01e8cd7320c030e57d8e4858ae246b21a37f6f390be78cadeb8ad646b3</citedby><cites>FETCH-LOGICAL-c5675-6ec7c5b01e8cd7320c030e57d8e4858ae246b21a37f6f390be78cadeb8ad646b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fjphysiol.2004.077412$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fjphysiol.2004.077412$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15539395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1960550$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Fisahn, André</creatorcontrib><creatorcontrib>Heinemann, Stephen F.</creatorcontrib><creatorcontrib>McBain, Chris J.</creatorcontrib><title>The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>Kainate receptors (KARs) play an important role in synaptic physiology, plasticity and pathological phenomena such as epilepsy.
However, the physiological implications for single cells and neuronal networks of the distinct expression patterns of KAR
subunits are unknown. One intriguing effect of KAR activation is a long-term change to intrinsic neuronal excitability and
neuronal firing patterns, such as single-spike and spike-burst firing. In this study, we describe the role of kainate receptor
subunits in the metabotropic regulation of the slow and medium afterhyperpolarization (AHP) currents ( I sAHP , I mAHP ). Using whole-cell patch-clamp recordings from CA3 pyramidal cells of wild-type (WT) and KAR knockout mice, we show that
the kainate-induced decrease of I sAHP and I mAHP amplitude is protein-kinase-C-dependent and absent in GluR6 â/â but not GluR5 â/â pyramidal neurones. Our findings suggest that activation of GluR6-containing KARs modulates AHP amplitude, and influences
the firing frequency of pyramidal neurones.</description><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Electrophysiology</subject><subject>Excitatory Amino Acid Agonists - pharmacology</subject><subject>GluK2 Kainate Receptor</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - physiology</subject><subject>In Vitro Techniques</subject><subject>Kainic Acid - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Patch-Clamp Techniques</subject><subject>Pyramidal Cells - physiology</subject><subject>Receptors, Kainic Acid - genetics</subject><subject>Receptors, Kainic Acid - physiology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNkd1u1DAQhSMEokvhDRDyFVxl8U9sJ5dVBW1RJSq0XFuOM2ncJnHwj1b7ALw3XrKFS7ia0cx3jsY-RfGW4C0hhH18WIZDsG7cUoyrLZayIvRZsSGVaEopG_a82GBMackkJ2fFqxAeMCYMN83L4oxwzhrW8E3xczcAetR21hGQBwNLdB6F1KbZRnQ1pm8CTdDZvA65ibp10bvFmgzfp1FH62bkehSzTRjdHum5-y1IE7q4vkMmeQ9zDMjOaHIpABrssjijp0WPaIbk3QzhdfGi12OAN6d6Xnz__Gl3eV3efr26uby4LQ0XkpcCjDS8xQRq00lGscEMA5ddDVXNaw20Ei0lmsle9KzBLcja6A7aWncir9h5Ua6-YQ9LatXi7aT9QTlt1Wn0mDtQvGaUNpl_v_KLdz8ShKgmGwyMo54hP0YJySpGBfknSCTDTIg6g9UKGu9C8ND_uYFgdcxVPeWqjrmqNdcse3fyT23-3b-iU5AZqFdgb0c4_Jep2n25E9VR-mGVDvZ-2FsPaoWDMxbiQXFBFVGkadgvZCHEFQ</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Fisahn, André</creator><creator>Heinemann, Stephen F.</creator><creator>McBain, Chris J.</creator><general>The Physiological Society</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>200501</creationdate><title>The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones</title><author>Fisahn, André ; Heinemann, Stephen F. ; McBain, Chris J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5675-6ec7c5b01e8cd7320c030e57d8e4858ae246b21a37f6f390be78cadeb8ad646b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Electrophysiology</topic><topic>Excitatory Amino Acid Agonists - pharmacology</topic><topic>GluK2 Kainate Receptor</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - physiology</topic><topic>In Vitro Techniques</topic><topic>Kainic Acid - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Patch-Clamp Techniques</topic><topic>Pyramidal Cells - physiology</topic><topic>Receptors, Kainic Acid - genetics</topic><topic>Receptors, Kainic Acid - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fisahn, André</creatorcontrib><creatorcontrib>Heinemann, Stephen F.</creatorcontrib><creatorcontrib>McBain, Chris J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fisahn, André</au><au>Heinemann, Stephen F.</au><au>McBain, Chris J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>2005-01</date><risdate>2005</risdate><volume>562</volume><issue>1</issue><spage>199</spage><epage>203</epage><pages>199-203</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>Kainate receptors (KARs) play an important role in synaptic physiology, plasticity and pathological phenomena such as epilepsy.
However, the physiological implications for single cells and neuronal networks of the distinct expression patterns of KAR
subunits are unknown. One intriguing effect of KAR activation is a long-term change to intrinsic neuronal excitability and
neuronal firing patterns, such as single-spike and spike-burst firing. In this study, we describe the role of kainate receptor
subunits in the metabotropic regulation of the slow and medium afterhyperpolarization (AHP) currents ( I sAHP , I mAHP ). Using whole-cell patch-clamp recordings from CA3 pyramidal cells of wild-type (WT) and KAR knockout mice, we show that
the kainate-induced decrease of I sAHP and I mAHP amplitude is protein-kinase-C-dependent and absent in GluR6 â/â but not GluR5 â/â pyramidal neurones. Our findings suggest that activation of GluR6-containing KARs modulates AHP amplitude, and influences
the firing frequency of pyramidal neurones.</abstract><cop>9600 Garsington Road , Oxford , OX4 2DQ , UK</cop><pub>The Physiological Society</pub><pmid>15539395</pmid><doi>10.1113/jphysiol.2004.077412</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Action Potentials - physiology Animals Electrophysiology Excitatory Amino Acid Agonists - pharmacology GluK2 Kainate Receptor Hippocampus - cytology Hippocampus - physiology In Vitro Techniques Kainic Acid - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Patch-Clamp Techniques Pyramidal Cells - physiology Receptors, Kainic Acid - genetics Receptors, Kainic Acid - physiology |
| title | The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones |
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