Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: Relationship to Morris water maze performance
Estrogen modulates NMDA receptors function in the brain. It increases both dendritic spine density and synapse number in the hippocampus, an effect that can be blocked by NMDA antagonist. In this study, we investigated the effect of 17β‐estradiol and progesterone treatment on NMDA receptors in ovari...
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| creator | El‐Bakri, Nahid K. Islam, Atiqul Zhu, Shunwei Elhassan, Adlan Mohammed, Abdul Winblad, Bengt Adem, Abdu |
| description | Estrogen modulates NMDA receptors function in the brain. It increases both dendritic spine density and synapse number in the hippocampus, an effect that can be blocked by NMDA antagonist. In this study, we investigated the effect of 17β‐estradiol and progesterone treatment on NMDA receptors in ovariectomized rats. Two different doses were used for 10 weeks. Receptor autoradiography was done on brain sections using [3H] MK‐801 as a ligand. Our results showed a significant increase in [3H] MK‐801 binding in the dentate gyrus, CA3 and CA4 areas of the hippocampus of ovariectomized compared to sham operated rats. In addition, we observed similar changes in CA1. 17β‐estradiol treatment in both doses reduced the binding back to the normal level while progesterone treatment did not show any effect. Spatial reference memory was tested on Morris water maze task. Ovariectomy severely impaired spatial reference memory. Estradiol but not progesterone treatment significantly improved the memory performance of the ovariectomized rats. Low dose treatment showed better learning than high dose estrogen treatment. The decrease in the antagonist sites by estradiol treatment could result in an increase in the sensitivity of the hippocampus to the excitatory stimulation by glutamate system and hence the effect of estradiol on learning and memory. The changes of NMDA receptors in the hippocampus support the concept that estrogen‐enhancing effect on spatial reference memory could be through the enhancing of NMDA function. |
| doi_str_mv | 10.1111/j.1582-4934.2004.tb00478.x |
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It increases both dendritic spine density and synapse number in the hippocampus, an effect that can be blocked by NMDA antagonist. In this study, we investigated the effect of 17β‐estradiol and progesterone treatment on NMDA receptors in ovariectomized rats. Two different doses were used for 10 weeks. Receptor autoradiography was done on brain sections using [3H] MK‐801 as a ligand. Our results showed a significant increase in [3H] MK‐801 binding in the dentate gyrus, CA3 and CA4 areas of the hippocampus of ovariectomized compared to sham operated rats. In addition, we observed similar changes in CA1. 17β‐estradiol treatment in both doses reduced the binding back to the normal level while progesterone treatment did not show any effect. Spatial reference memory was tested on Morris water maze task. Ovariectomy severely impaired spatial reference memory. Estradiol but not progesterone treatment significantly improved the memory performance of the ovariectomized rats. Low dose treatment showed better learning than high dose estrogen treatment. The decrease in the antagonist sites by estradiol treatment could result in an increase in the sensitivity of the hippocampus to the excitatory stimulation by glutamate system and hence the effect of estradiol on learning and memory. The changes of NMDA receptors in the hippocampus support the concept that estrogen‐enhancing effect on spatial reference memory could be through the enhancing of NMDA function.</description><identifier>ISSN: 1582-1838</identifier><identifier>ISSN: 1582-4934</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/j.1582-4934.2004.tb00478.x</identifier><identifier>PMID: 15601582</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>17β-Estradiol ; Amino acids ; Animals ; Autoradiography ; Brain - metabolism ; Concept learning ; Dendrites - pathology ; Dendritic spines ; Dentate gyrus ; Dentate Gyrus - drug effects ; Dentate Gyrus - pathology ; Dizocilpine ; Dizocilpine Maleate - pharmacology ; Estradiol ; Estradiol - metabolism ; Estrogens ; Estrogens - metabolism ; Estrogens - pharmacology ; Excitatory Amino Acid Antagonists - pharmacology ; Female ; Glutamate ; Glutamic acid receptors (ionotropic) ; Hippocampus ; Hippocampus - metabolism ; Hippocampus - pathology ; Ligands ; Maze Learning ; Mental task performance ; MK‐801 ; N-Methyl-D-aspartic acid receptors ; N-Methylaspartate - antagonists & inhibitors ; Neurophysiology ; NMDA ; Ovariectomy ; Ovary - pathology ; Phenols ; Progesterone ; Progesterone - metabolism ; Progesterone - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptor mechanisms ; Receptors, N-Methyl-D-Aspartate - metabolism ; reference memory ; Spatial discrimination learning ; Spatial memory ; Synapses ; Time Factors</subject><ispartof>Journal of cellular and molecular medicine, 2004-10, Vol.8 (4), p.537-544</ispartof><rights>COPYRIGHT 2004 John Wiley & Sons, Inc.</rights><rights>2004. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6427-1725f0ae92746b660dee1bd88a68094086fc2507730cdc97cd98b831c4be0c343</citedby><cites>FETCH-LOGICAL-c6427-1725f0ae92746b660dee1bd88a68094086fc2507730cdc97cd98b831c4be0c343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740259/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740259/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,550,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1582-4934.2004.tb00478.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15601582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1954797$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>El‐Bakri, Nahid K.</creatorcontrib><creatorcontrib>Islam, Atiqul</creatorcontrib><creatorcontrib>Zhu, Shunwei</creatorcontrib><creatorcontrib>Elhassan, Adlan</creatorcontrib><creatorcontrib>Mohammed, Abdul</creatorcontrib><creatorcontrib>Winblad, Bengt</creatorcontrib><creatorcontrib>Adem, Abdu</creatorcontrib><title>Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: Relationship to Morris water maze performance</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Estrogen modulates NMDA receptors function in the brain. It increases both dendritic spine density and synapse number in the hippocampus, an effect that can be blocked by NMDA antagonist. In this study, we investigated the effect of 17β‐estradiol and progesterone treatment on NMDA receptors in ovariectomized rats. Two different doses were used for 10 weeks. Receptor autoradiography was done on brain sections using [3H] MK‐801 as a ligand. Our results showed a significant increase in [3H] MK‐801 binding in the dentate gyrus, CA3 and CA4 areas of the hippocampus of ovariectomized compared to sham operated rats. In addition, we observed similar changes in CA1. 17β‐estradiol treatment in both doses reduced the binding back to the normal level while progesterone treatment did not show any effect. Spatial reference memory was tested on Morris water maze task. Ovariectomy severely impaired spatial reference memory. Estradiol but not progesterone treatment significantly improved the memory performance of the ovariectomized rats. Low dose treatment showed better learning than high dose estrogen treatment. The decrease in the antagonist sites by estradiol treatment could result in an increase in the sensitivity of the hippocampus to the excitatory stimulation by glutamate system and hence the effect of estradiol on learning and memory. The changes of NMDA receptors in the hippocampus support the concept that estrogen‐enhancing effect on spatial reference memory could be through the enhancing of NMDA function.</description><subject>17β-Estradiol</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Autoradiography</subject><subject>Brain - metabolism</subject><subject>Concept learning</subject><subject>Dendrites - pathology</subject><subject>Dendritic spines</subject><subject>Dentate gyrus</subject><subject>Dentate Gyrus - drug effects</subject><subject>Dentate Gyrus - pathology</subject><subject>Dizocilpine</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Estradiol</subject><subject>Estradiol - metabolism</subject><subject>Estrogens</subject><subject>Estrogens - metabolism</subject><subject>Estrogens - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Female</subject><subject>Glutamate</subject><subject>Glutamic acid receptors (ionotropic)</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Ligands</subject><subject>Maze Learning</subject><subject>Mental task performance</subject><subject>MK‐801</subject><subject>N-Methyl-D-aspartic acid receptors</subject><subject>N-Methylaspartate - antagonists & inhibitors</subject><subject>Neurophysiology</subject><subject>NMDA</subject><subject>Ovariectomy</subject><subject>Ovary - pathology</subject><subject>Phenols</subject><subject>Progesterone</subject><subject>Progesterone - metabolism</subject><subject>Progesterone - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor mechanisms</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>reference memory</subject><subject>Spatial discrimination learning</subject><subject>Spatial memory</subject><subject>Synapses</subject><subject>Time Factors</subject><issn>1582-1838</issn><issn>1582-4934</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNqVkktv1DAUhSMEog_4C8gCid0EO3Zspwuq0VBe6oCEYG05zs00Q2IH28O03fDXcTRRoexIpOTK9zvH8c3JsucE5yRdr7Y5KWWxYBVleYExy2OdnkLm1w-y47vWw7kmksqj7CSELcaUE1o9zo5IyfHUPM5-XbQtmBiQaxGE6N0GLNK2QeNUhgjeWUDRg44D2IicRV5HdNWNozN6GHWPPq3fLJEHA2N0PpyhL9Dr2DkbEoSiQ2vnfRfQXiczNOhbQCP41vlBWwNPsket7gM8nd-n2be3F19X7xeXn999WC0vF4azQiyIKMoWa6gKwXjNOW4ASN1IqbnEFcOSt6YosRAUm8ZUwjSVrCUlhtWADWX0NFscfMMexl2tRt8N2t8opzs1L31PFag0FYkn_vWBT50BGpPO7nV_T3a_Y7srtXE_FRcMF2WVDF7OBt792KVJqqELBvpeW3C7kDgiGS14Al_8A27dzts0DEWxYIIXtMSJyg_URvegOtu6tKtJdwNDZ9I_aru0vhSkrMqCyzIJzg4C410IHtq7bydYTTFSWzVFQE1ZUVOM1BwjdZ3Ez_4-_R_pnJsEnB-Afdr25j-s1cfVel1SQX8Dv1Ha3w</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>El‐Bakri, Nahid K.</creator><creator>Islam, Atiqul</creator><creator>Zhu, Shunwei</creator><creator>Elhassan, Adlan</creator><creator>Mohammed, Abdul</creator><creator>Winblad, Bengt</creator><creator>Adem, Abdu</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>200410</creationdate><title>Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: Relationship to Morris water maze performance</title><author>El‐Bakri, Nahid K. ; Islam, Atiqul ; Zhu, Shunwei ; Elhassan, Adlan ; Mohammed, Abdul ; Winblad, Bengt ; Adem, Abdu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6427-1725f0ae92746b660dee1bd88a68094086fc2507730cdc97cd98b831c4be0c343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>17β-Estradiol</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Autoradiography</topic><topic>Brain - metabolism</topic><topic>Concept learning</topic><topic>Dendrites - pathology</topic><topic>Dendritic spines</topic><topic>Dentate gyrus</topic><topic>Dentate Gyrus - drug effects</topic><topic>Dentate Gyrus - pathology</topic><topic>Dizocilpine</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Estradiol</topic><topic>Estradiol - metabolism</topic><topic>Estrogens</topic><topic>Estrogens - metabolism</topic><topic>Estrogens - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Female</topic><topic>Glutamate</topic><topic>Glutamic acid receptors (ionotropic)</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - pathology</topic><topic>Ligands</topic><topic>Maze Learning</topic><topic>Mental task performance</topic><topic>MK‐801</topic><topic>N-Methyl-D-aspartic acid receptors</topic><topic>N-Methylaspartate - antagonists & inhibitors</topic><topic>Neurophysiology</topic><topic>NMDA</topic><topic>Ovariectomy</topic><topic>Ovary - pathology</topic><topic>Phenols</topic><topic>Progesterone</topic><topic>Progesterone - metabolism</topic><topic>Progesterone - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor mechanisms</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>reference memory</topic><topic>Spatial discrimination learning</topic><topic>Spatial memory</topic><topic>Synapses</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El‐Bakri, Nahid K.</creatorcontrib><creatorcontrib>Islam, Atiqul</creatorcontrib><creatorcontrib>Zhu, Shunwei</creatorcontrib><creatorcontrib>Elhassan, Adlan</creatorcontrib><creatorcontrib>Mohammed, Abdul</creatorcontrib><creatorcontrib>Winblad, Bengt</creatorcontrib><creatorcontrib>Adem, Abdu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>El‐Bakri, Nahid K.</au><au>Islam, Atiqul</au><au>Zhu, Shunwei</au><au>Elhassan, Adlan</au><au>Mohammed, Abdul</au><au>Winblad, Bengt</au><au>Adem, Abdu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: Relationship to Morris water maze performance</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2004-10</date><risdate>2004</risdate><volume>8</volume><issue>4</issue><spage>537</spage><epage>544</epage><pages>537-544</pages><issn>1582-1838</issn><issn>1582-4934</issn><eissn>1582-4934</eissn><abstract>Estrogen modulates NMDA receptors function in the brain. It increases both dendritic spine density and synapse number in the hippocampus, an effect that can be blocked by NMDA antagonist. In this study, we investigated the effect of 17β‐estradiol and progesterone treatment on NMDA receptors in ovariectomized rats. Two different doses were used for 10 weeks. Receptor autoradiography was done on brain sections using [3H] MK‐801 as a ligand. Our results showed a significant increase in [3H] MK‐801 binding in the dentate gyrus, CA3 and CA4 areas of the hippocampus of ovariectomized compared to sham operated rats. In addition, we observed similar changes in CA1. 17β‐estradiol treatment in both doses reduced the binding back to the normal level while progesterone treatment did not show any effect. Spatial reference memory was tested on Morris water maze task. Ovariectomy severely impaired spatial reference memory. Estradiol but not progesterone treatment significantly improved the memory performance of the ovariectomized rats. Low dose treatment showed better learning than high dose estrogen treatment. The decrease in the antagonist sites by estradiol treatment could result in an increase in the sensitivity of the hippocampus to the excitatory stimulation by glutamate system and hence the effect of estradiol on learning and memory. The changes of NMDA receptors in the hippocampus support the concept that estrogen‐enhancing effect on spatial reference memory could be through the enhancing of NMDA function.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15601582</pmid><doi>10.1111/j.1582-4934.2004.tb00478.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cellular and molecular medicine, 2004-10, Vol.8 (4), p.537-544 |
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| subjects | 17β-Estradiol Amino acids Animals Autoradiography Brain - metabolism Concept learning Dendrites - pathology Dendritic spines Dentate gyrus Dentate Gyrus - drug effects Dentate Gyrus - pathology Dizocilpine Dizocilpine Maleate - pharmacology Estradiol Estradiol - metabolism Estrogens Estrogens - metabolism Estrogens - pharmacology Excitatory Amino Acid Antagonists - pharmacology Female Glutamate Glutamic acid receptors (ionotropic) Hippocampus Hippocampus - metabolism Hippocampus - pathology Ligands Maze Learning Mental task performance MK‐801 N-Methyl-D-aspartic acid receptors N-Methylaspartate - antagonists & inhibitors Neurophysiology NMDA Ovariectomy Ovary - pathology Phenols Progesterone Progesterone - metabolism Progesterone - pharmacology Rats Rats, Sprague-Dawley Receptor mechanisms Receptors, N-Methyl-D-Aspartate - metabolism reference memory Spatial discrimination learning Spatial memory Synapses Time Factors |
| title | Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: Relationship to Morris water maze performance |
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