Antibody profiles and self‐reported symptoms to pollen‐related food allergens in grass pollen‐allergic patients from northern Europe
Background: Most studies on pollen‐related food allergy have so far focused on the association of birch/weed pollen allergens and plant food allergy. The aim of this study was to elucidate the allergen spectrum among a group of grass pollen‐allergic patients from northern Europe and to relate the r...
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| Veröffentlicht in: | Allergy (Copenhagen) 2005-02, Vol.60 (2), p.185-191 |
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| creator | Ghunaim, N. Grönlund, H. Kronqvist, M. Grönneberg, R. Söderström, L. Ahlstedt, S. Van Hage‐Hamsten, M. |
| description | Background: Most studies on pollen‐related food allergy have so far focused on the association of birch/weed pollen allergens and plant food allergy. The aim of this study was to elucidate the allergen spectrum among a group of grass pollen‐allergic patients from northern Europe and to relate the results to clinical histories of pollen‐related food allergy.
Methods: Fifty‐eight grass pollen‐allergic patients answered a questionnaire regarding allergy to foods. Blood samples were taken to test IgE‐reactivity to a large panel of pollen allergens and pollen‐ and nonpollen‐related food allergens using crude allergen extracts and recombinant and native allergens.
Results: Three different groups of grass pollen‐allergic patients were identified according to their IgE antibody profile: a grass pollen group only (19%), a grass and tree pollen group (29%) and a grass, tree and compositae (pan‐) pollen group (48%). No sensitization to Bet v 1 as well as almost no IgE to plant food was observed in the grass pollen group. In contrast, nearly all patients in the two tree‐related groups had IgE to Bet v 1, which reflected the high frequency of adverse reactions to typical birch‐related food in these groups. Only four patients belonging to the pan‐pollen group displayed IgE to profilin Phl p 12/Bet v 2. Patients in the pan‐pollen group reported significantly more symptoms to food allergens compared with patients in the two other groups. The most frequently reported symptom was the oral allergy syndrome.
Conclusions: Sensitization to grass pollen alone is rare among grass pollen‐allergic patients from northern Europe. The majority of patients are in addition sensitized to birch (Bet v 1), which seems to be closely related to their pollen‐derived food allergy. The study highlights the advantage of using well‐defined allergen molecules for the diagnosis of cross‐reactivity between pollen and food allergens. |
| doi_str_mv | 10.1111/j.1398-9995.2005.00662.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_582534</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17384830</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6062-2037fb218ca98858062e92ea4c076ad70d602d6d9d9172ba78d5745713eeba0e3</originalsourceid><addsrcrecordid>eNqNkk2LFDEQhoMo7jj6FyQIeusxSXe-wMuw7Kow4EXPId2pXnvsTtqkm925efbkb9xfYubDHRAEc0lS9bxFpfIihClZ0bzeble01KrQWvMVI4SvCBGCre4eocVD4jFaEEp4UfFSXaBnKW0JIZJp8hRdUC4qSUq9QD_Xfurq4HZ4jKHtekjYeocT9O39j18RxhAnyPfdME5hSHgKeAx9D_6Q7e0-2YbgsM3BeAM-4c7jm2hTOoPHXNfg0U4d-CnhNoYB-1z7K0SPr-YYRniOnrS2T_DitC_Rl-urz5cfis2n9x8v15uiEUSwgpFStjWjqrFaKa5yDDQDWzVECuskcYIwJ5x2mkpWW6kclxWXtASoLYFyiYpj3XQL41ybMXaDjTsTbGdOoW_5BIYrxssq8_KffB6aO4v-CKnmeeokK98clRn7PkOazNClBvreeghzMlSWqlIH8NVf4DbM0ecp5FpCk0P7S6SOUBNDShHah04oMXtbmK3Z_77Z_77Z28IcbGHusvTlqf5cD-DOwpMPMvD6BNjU2L6N1jddOnMiP0dIlrl3R-42W2X33w2Y9WaTD-VvgdXZ6A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>196904571</pqid></control><display><type>article</type><title>Antibody profiles and self‐reported symptoms to pollen‐related food allergens in grass pollen‐allergic patients from northern Europe</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><creator>Ghunaim, N. ; Grönlund, H. ; Kronqvist, M. ; Grönneberg, R. ; Söderström, L. ; Ahlstedt, S. ; Van Hage‐Hamsten, M.</creator><creatorcontrib>Ghunaim, N. ; Grönlund, H. ; Kronqvist, M. ; Grönneberg, R. ; Söderström, L. ; Ahlstedt, S. ; Van Hage‐Hamsten, M.</creatorcontrib><description>Background: Most studies on pollen‐related food allergy have so far focused on the association of birch/weed pollen allergens and plant food allergy. The aim of this study was to elucidate the allergen spectrum among a group of grass pollen‐allergic patients from northern Europe and to relate the results to clinical histories of pollen‐related food allergy.
Methods: Fifty‐eight grass pollen‐allergic patients answered a questionnaire regarding allergy to foods. Blood samples were taken to test IgE‐reactivity to a large panel of pollen allergens and pollen‐ and nonpollen‐related food allergens using crude allergen extracts and recombinant and native allergens.
Results: Three different groups of grass pollen‐allergic patients were identified according to their IgE antibody profile: a grass pollen group only (19%), a grass and tree pollen group (29%) and a grass, tree and compositae (pan‐) pollen group (48%). No sensitization to Bet v 1 as well as almost no IgE to plant food was observed in the grass pollen group. In contrast, nearly all patients in the two tree‐related groups had IgE to Bet v 1, which reflected the high frequency of adverse reactions to typical birch‐related food in these groups. Only four patients belonging to the pan‐pollen group displayed IgE to profilin Phl p 12/Bet v 2. Patients in the pan‐pollen group reported significantly more symptoms to food allergens compared with patients in the two other groups. The most frequently reported symptom was the oral allergy syndrome.
Conclusions: Sensitization to grass pollen alone is rare among grass pollen‐allergic patients from northern Europe. The majority of patients are in addition sensitized to birch (Bet v 1), which seems to be closely related to their pollen‐derived food allergy. The study highlights the advantage of using well‐defined allergen molecules for the diagnosis of cross‐reactivity between pollen and food allergens.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/j.1398-9995.2005.00662.x</identifier><identifier>PMID: 15647039</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adult ; Allergens - immunology ; Allergic diseases ; Allergies ; allergy ; Antibodies - blood ; Betula - immunology ; Biological and medical sciences ; Cross Reactions ; Environmental Exposure ; Europe ; Female ; Food ; food allergens ; Food Hypersensitivity - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Grasses ; Humans ; Hypersensitivity - immunology ; Immunoglobulin E - analysis ; Immunopathology ; Male ; Medical Records ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Poaceae - immunology ; Pollen ; Pollen - immunology ; pollen allergens ; recombinant allergens ; Surveys and Questionnaires</subject><ispartof>Allergy (Copenhagen), 2005-02, Vol.60 (2), p.185-191</ispartof><rights>2005 INIST-CNRS</rights><rights>2005 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6062-2037fb218ca98858062e92ea4c076ad70d602d6d9d9172ba78d5745713eeba0e3</citedby><cites>FETCH-LOGICAL-c6062-2037fb218ca98858062e92ea4c076ad70d602d6d9d9172ba78d5745713eeba0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1398-9995.2005.00662.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1398-9995.2005.00662.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16530672$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15647039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1954530$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghunaim, N.</creatorcontrib><creatorcontrib>Grönlund, H.</creatorcontrib><creatorcontrib>Kronqvist, M.</creatorcontrib><creatorcontrib>Grönneberg, R.</creatorcontrib><creatorcontrib>Söderström, L.</creatorcontrib><creatorcontrib>Ahlstedt, S.</creatorcontrib><creatorcontrib>Van Hage‐Hamsten, M.</creatorcontrib><title>Antibody profiles and self‐reported symptoms to pollen‐related food allergens in grass pollen‐allergic patients from northern Europe</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background: Most studies on pollen‐related food allergy have so far focused on the association of birch/weed pollen allergens and plant food allergy. The aim of this study was to elucidate the allergen spectrum among a group of grass pollen‐allergic patients from northern Europe and to relate the results to clinical histories of pollen‐related food allergy.
Methods: Fifty‐eight grass pollen‐allergic patients answered a questionnaire regarding allergy to foods. Blood samples were taken to test IgE‐reactivity to a large panel of pollen allergens and pollen‐ and nonpollen‐related food allergens using crude allergen extracts and recombinant and native allergens.
Results: Three different groups of grass pollen‐allergic patients were identified according to their IgE antibody profile: a grass pollen group only (19%), a grass and tree pollen group (29%) and a grass, tree and compositae (pan‐) pollen group (48%). No sensitization to Bet v 1 as well as almost no IgE to plant food was observed in the grass pollen group. In contrast, nearly all patients in the two tree‐related groups had IgE to Bet v 1, which reflected the high frequency of adverse reactions to typical birch‐related food in these groups. Only four patients belonging to the pan‐pollen group displayed IgE to profilin Phl p 12/Bet v 2. Patients in the pan‐pollen group reported significantly more symptoms to food allergens compared with patients in the two other groups. The most frequently reported symptom was the oral allergy syndrome.
Conclusions: Sensitization to grass pollen alone is rare among grass pollen‐allergic patients from northern Europe. The majority of patients are in addition sensitized to birch (Bet v 1), which seems to be closely related to their pollen‐derived food allergy. The study highlights the advantage of using well‐defined allergen molecules for the diagnosis of cross‐reactivity between pollen and food allergens.</description><subject>Adult</subject><subject>Allergens - immunology</subject><subject>Allergic diseases</subject><subject>Allergies</subject><subject>allergy</subject><subject>Antibodies - blood</subject><subject>Betula - immunology</subject><subject>Biological and medical sciences</subject><subject>Cross Reactions</subject><subject>Environmental Exposure</subject><subject>Europe</subject><subject>Female</subject><subject>Food</subject><subject>food allergens</subject><subject>Food Hypersensitivity - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Grasses</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Immunoglobulin E - analysis</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Poaceae - immunology</subject><subject>Pollen</subject><subject>Pollen - immunology</subject><subject>pollen allergens</subject><subject>recombinant allergens</subject><subject>Surveys and Questionnaires</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2LFDEQhoMo7jj6FyQIeusxSXe-wMuw7Kow4EXPId2pXnvsTtqkm925efbkb9xfYubDHRAEc0lS9bxFpfIihClZ0bzeble01KrQWvMVI4SvCBGCre4eocVD4jFaEEp4UfFSXaBnKW0JIZJp8hRdUC4qSUq9QD_Xfurq4HZ4jKHtekjYeocT9O39j18RxhAnyPfdME5hSHgKeAx9D_6Q7e0-2YbgsM3BeAM-4c7jm2hTOoPHXNfg0U4d-CnhNoYB-1z7K0SPr-YYRniOnrS2T_DitC_Rl-urz5cfis2n9x8v15uiEUSwgpFStjWjqrFaKa5yDDQDWzVECuskcYIwJ5x2mkpWW6kclxWXtASoLYFyiYpj3XQL41ybMXaDjTsTbGdOoW_5BIYrxssq8_KffB6aO4v-CKnmeeokK98clRn7PkOazNClBvreeghzMlSWqlIH8NVf4DbM0ecp5FpCk0P7S6SOUBNDShHah04oMXtbmK3Z_77Z_77Z28IcbGHusvTlqf5cD-DOwpMPMvD6BNjU2L6N1jddOnMiP0dIlrl3R-42W2X33w2Y9WaTD-VvgdXZ6A</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Ghunaim, N.</creator><creator>Grönlund, H.</creator><creator>Kronqvist, M.</creator><creator>Grönneberg, R.</creator><creator>Söderström, L.</creator><creator>Ahlstedt, S.</creator><creator>Van Hage‐Hamsten, M.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>200502</creationdate><title>Antibody profiles and self‐reported symptoms to pollen‐related food allergens in grass pollen‐allergic patients from northern Europe</title><author>Ghunaim, N. ; Grönlund, H. ; Kronqvist, M. ; Grönneberg, R. ; Söderström, L. ; Ahlstedt, S. ; Van Hage‐Hamsten, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6062-2037fb218ca98858062e92ea4c076ad70d602d6d9d9172ba78d5745713eeba0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Allergens - immunology</topic><topic>Allergic diseases</topic><topic>Allergies</topic><topic>allergy</topic><topic>Antibodies - blood</topic><topic>Betula - immunology</topic><topic>Biological and medical sciences</topic><topic>Cross Reactions</topic><topic>Environmental Exposure</topic><topic>Europe</topic><topic>Female</topic><topic>Food</topic><topic>food allergens</topic><topic>Food Hypersensitivity - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Grasses</topic><topic>Humans</topic><topic>Hypersensitivity - immunology</topic><topic>Immunoglobulin E - analysis</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Poaceae - immunology</topic><topic>Pollen</topic><topic>Pollen - immunology</topic><topic>pollen allergens</topic><topic>recombinant allergens</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghunaim, N.</creatorcontrib><creatorcontrib>Grönlund, H.</creatorcontrib><creatorcontrib>Kronqvist, M.</creatorcontrib><creatorcontrib>Grönneberg, R.</creatorcontrib><creatorcontrib>Söderström, L.</creatorcontrib><creatorcontrib>Ahlstedt, S.</creatorcontrib><creatorcontrib>Van Hage‐Hamsten, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghunaim, N.</au><au>Grönlund, H.</au><au>Kronqvist, M.</au><au>Grönneberg, R.</au><au>Söderström, L.</au><au>Ahlstedt, S.</au><au>Van Hage‐Hamsten, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody profiles and self‐reported symptoms to pollen‐related food allergens in grass pollen‐allergic patients from northern Europe</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2005-02</date><risdate>2005</risdate><volume>60</volume><issue>2</issue><spage>185</spage><epage>191</epage><pages>185-191</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><coden>LLRGDY</coden><abstract>Background: Most studies on pollen‐related food allergy have so far focused on the association of birch/weed pollen allergens and plant food allergy. The aim of this study was to elucidate the allergen spectrum among a group of grass pollen‐allergic patients from northern Europe and to relate the results to clinical histories of pollen‐related food allergy.
Methods: Fifty‐eight grass pollen‐allergic patients answered a questionnaire regarding allergy to foods. Blood samples were taken to test IgE‐reactivity to a large panel of pollen allergens and pollen‐ and nonpollen‐related food allergens using crude allergen extracts and recombinant and native allergens.
Results: Three different groups of grass pollen‐allergic patients were identified according to their IgE antibody profile: a grass pollen group only (19%), a grass and tree pollen group (29%) and a grass, tree and compositae (pan‐) pollen group (48%). No sensitization to Bet v 1 as well as almost no IgE to plant food was observed in the grass pollen group. In contrast, nearly all patients in the two tree‐related groups had IgE to Bet v 1, which reflected the high frequency of adverse reactions to typical birch‐related food in these groups. Only four patients belonging to the pan‐pollen group displayed IgE to profilin Phl p 12/Bet v 2. Patients in the pan‐pollen group reported significantly more symptoms to food allergens compared with patients in the two other groups. The most frequently reported symptom was the oral allergy syndrome.
Conclusions: Sensitization to grass pollen alone is rare among grass pollen‐allergic patients from northern Europe. The majority of patients are in addition sensitized to birch (Bet v 1), which seems to be closely related to their pollen‐derived food allergy. The study highlights the advantage of using well‐defined allergen molecules for the diagnosis of cross‐reactivity between pollen and food allergens.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>15647039</pmid><doi>10.1111/j.1398-9995.2005.00662.x</doi><tpages>7</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | Adult Allergens - immunology Allergic diseases Allergies allergy Antibodies - blood Betula - immunology Biological and medical sciences Cross Reactions Environmental Exposure Europe Female Food food allergens Food Hypersensitivity - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Grasses Humans Hypersensitivity - immunology Immunoglobulin E - analysis Immunopathology Male Medical Records Medical sciences Medicin och hälsovetenskap Middle Aged Poaceae - immunology Pollen Pollen - immunology pollen allergens recombinant allergens Surveys and Questionnaires |
| title | Antibody profiles and self‐reported symptoms to pollen‐related food allergens in grass pollen‐allergic patients from northern Europe |
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