Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis

We hypothesized that the ability of BCG vaccination to protect against Mycobacterium tuberculosis is less in hosts exposed to chronic helminthes infection compared to unexposed individuals. To test this hypothesis we evaluated the efficacy of BCG vaccination in protecting against M. tuberculosis cha...

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Veröffentlicht in:	Vaccine 2005-02, Vol.23 (11), p.1326-1334
Hauptverfasser:	Elias, Daniel, Akuffo, Hannah, Pawlowski, Andrzej, Haile, Melles, Schön, Thomas, Britton, Sven
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied microbiology Bacterial diseases BCG Vaccine - immunology Biological and medical sciences Chronic Disease Colony Count, Microbial Disease Models, Animal Diseases caused by trematodes Female Fundamental and applied biological sciences. Psychology Helminthes Helminthic diseases Helminths Human bacterial diseases Infectious diseases Interferon-gamma - biosynthesis Interleukin-4 - biosynthesis Interleukin-5 - biosynthesis Leukocytes - immunology Liver - microbiology Liver - pathology Lung - microbiology Lung - pathology Medical sciences MEDICIN MEDICINE Mice Mice, Inbred C57BL Microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Nitric Oxide - biosynthesis Parasitic diseases Schistosoma mansoni Schistosoma mansoni - immunology Schistosomiases Schistosomiasis mansoni - complications Schistosomiasis mansoni - immunology Schistosomiasis mansoni - pathology Spleen - microbiology Spleen - pathology Tuberculosis Tuberculosis - complications Tuberculosis - immunology Tuberculosis - pathology Tuberculosis and atypical mycobacterial infections Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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