Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function

Neuropeptide Y (NPY) has been implicated in the control of food intake and energy balance based on many observations in animals. We have studied single nucleotide polymorphisms (SNPs) within the regulatory and coding sequences of the human NPY gene. One variant (1128 T>C), which causes an amino a...

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Veröffentlicht in:	Regulatory peptides 2005-04, Vol.127 (1), p.45-53
Hauptverfasser:	Ding, Bo, Kull, Björn, Liu, Zhurong, Mottagui-Tabar, Salim, Thonberg, Håkan, Gu, Harvest F., Brookes, Anthony J., Grundemar, Lars, Karlsson, Christina, Hamsten, Anders, Arner, Peter, Östenson, Claes-Göran, Efendic, Suad, Monné, Magnus, von Heijne, Gunnar, Eriksson, Per, Wahlestedt, Claes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Association Biological and medical sciences Body Mass Index DNA Mutational Analysis Dose-Response Relationship, Drug Eating Endoplasmic Reticulum - metabolism Function Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Metabolic diseases Middle Aged Molecular Sequence Data Neuropeptide Y Neuropeptide Y - administration & dosage Neuropeptide Y - metabolism Neuropeptide Y/administration & dosage/metabolism Obesity Polymorphism Polymorphism, Genetic Protein Binding Protein Sorting Signals - genetics Rats Rats, Sprague-Dawley Recombinant Fusion Proteins - metabolism Signal Transduction - physiology Sweden Vertebrates: endocrinology
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