Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells

The majority of human melanomas harbor activating mutations in either the BRAF or NRAS gene. To date, the role of oncogenic NRAS in melanoma remains poorly defined and no current therapies are directed at specifically suppressing oncogenic NRAS in human melanoma tumors. The aim of our study, therefo...

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Veröffentlicht in:	International journal of cancer 2005-05, Vol.115 (1), p.65-73
Hauptverfasser:	Eskandarpour, Malihe, Kiaii, Shahryar, Zhu, Chaoyong, Castro, Juan, Sakko, Andrew J., Hansson, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Cell Line, Tumor Cell Proliferation Codon Coloring Agents - pharmacology Cyclin D1 - metabolism Dermatology Down-Regulation Ethidium - pharmacology Genes, ras - genetics Genetic Vectors Humans Immunoblotting In Situ Nick-End Labeling Medical sciences melanoma Melanoma - metabolism Melanoma - pathology Microscopy, Fluorescence Mitogen-Activated Protein Kinase 3 - metabolism Mutation Plasmids - metabolism Proto-Oncogene Proteins p21(ras) - metabolism Ras RNA Interference RNA, Small Interfering - metabolism RNAi Signal Transduction Time Factors Transfection Tumors Tumors of the skin and soft tissue. Premalignant lesions
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