Novel pathways of bile acid metabolism involving CYP3A4

The hepatic predominating cytochrome P450, CYP3A4, plays an essential role in the detoxification of bile acids and is important in pathological conditions such as cholestasis where CYP3A4 is adaptively up-regulated. However, the mechanism that triggers the up-regulation of CYP3A4 is still not clear....

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Veröffentlicht in:	Biochimica et biophysica acta 2005-02, Vol.1687 (1), p.84-93
Hauptverfasser:	Bodin, Karl, Lindbom, Ulla, Diczfalusy, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	1β-Hydroxy bile acid 3-Dehydro bile acid Animals Anticonvulsants - metabolism Bile Acids and Salts - chemistry Bile Acids and Salts - metabolism Carbamazepine Carbamazepine - metabolism Cholestasis Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Humans Mass Spectrometry Microsomes, Liver - chemistry Microsomes, Liver - metabolism Molecular Structure Oxygen Isotopes - metabolism Pregnane X receptor Recombinant Proteins - genetics Recombinant Proteins - metabolism
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