Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis

The intravenous anesthetic propofol is reported to have various psychological side effects as hallucinations, sexual disinhibition, or euphoria. Hedonic and rewarding states like these are modulated by the dopaminergic system in the nucleus accumbens, prefrontal cortex and also in the ventral pallid...

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Veröffentlicht in:	Amino acids 2005-03, Vol.28 (2), p.145-148
Hauptverfasser:	Grasshoff, C, Herrera-Marschitz, M, Goiny, M, Kretschmer, B D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anesthetics Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - adverse effects Animals Behavior, Animal - drug effects Bicuculline - administration & dosage Bicuculline - adverse effects Brain Chemistry - drug effects Chromatography, High Pressure Liquid Dialysis - methods Dopamine Dopamine - metabolism Feedback GABA Antagonists - administration & dosage GABA Antagonists - adverse effects Glutamates Glutamic Acid - metabolism Hallucinations - chemically induced Male Modulation Neurology Neurons - metabolism Nuclei Propofol - administration & dosage Propofol - adverse effects Rats Rats, Sprague-Dawley Receptors Rodents Sexual Dysfunctions, Psychological - chemically induced Telencephalon - metabolism
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