Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis
The intravenous anesthetic propofol is reported to have various psychological side effects as hallucinations, sexual disinhibition, or euphoria. Hedonic and rewarding states like these are modulated by the dopaminergic system in the nucleus accumbens, prefrontal cortex and also in the ventral pallid...
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| Veröffentlicht in: | Amino acids 2005-03, Vol.28 (2), p.145-148 |
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| description | The intravenous anesthetic propofol is reported to have various psychological side effects as hallucinations, sexual disinhibition, or euphoria. Hedonic and rewarding states like these are modulated by the dopaminergic system in the nucleus accumbens, prefrontal cortex and also in the ventral pallidum and by the glutamatergic system in the neocortex and limbic system. In the present study, propofol was administered either alone or in combination with the GABAA receptor antagonist bicuculline via reverse microdialysis into the ventral pallidum of freely moving rats. Dialysis fractions were taken every 20 min and analyzed for dopamine and glutamate using high performance liquid chromatography. Application of propofol decreased dopamine levels in the ventral pallidum. This effect seems to be mainly mediated through GABAA receptors, since it was compensated by the GABAA receptor antagonist bicuculline. Propofol and propofol plus bicuculline exerted no effect on glutamate release in this brain region. The reduced dopamine release in ventral pallidum was most probably mediated through a GABAergic feedback loop from the ventral pallidum via the nucleus accumbens to the dopaminergic neurons of the ventral tegmental area or by long loop feedback. As an increase but not a decrease of dopamine release in the ventral pallidum is involved in hedonic and rewarding properties, similar symptoms induced by propofol seem to be unrelated to an action of propofol in the ventral pallidum. |
| doi_str_mv | 10.1007/s00726-005-0160-6 |
| format | Article |
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Hedonic and rewarding states like these are modulated by the dopaminergic system in the nucleus accumbens, prefrontal cortex and also in the ventral pallidum and by the glutamatergic system in the neocortex and limbic system. In the present study, propofol was administered either alone or in combination with the GABAA receptor antagonist bicuculline via reverse microdialysis into the ventral pallidum of freely moving rats. Dialysis fractions were taken every 20 min and analyzed for dopamine and glutamate using high performance liquid chromatography. Application of propofol decreased dopamine levels in the ventral pallidum. This effect seems to be mainly mediated through GABAA receptors, since it was compensated by the GABAA receptor antagonist bicuculline. Propofol and propofol plus bicuculline exerted no effect on glutamate release in this brain region. The reduced dopamine release in ventral pallidum was most probably mediated through a GABAergic feedback loop from the ventral pallidum via the nucleus accumbens to the dopaminergic neurons of the ventral tegmental area or by long loop feedback. As an increase but not a decrease of dopamine release in the ventral pallidum is involved in hedonic and rewarding properties, similar symptoms induced by propofol seem to be unrelated to an action of propofol in the ventral pallidum.</description><identifier>ISSN: 0939-4451</identifier><identifier>EISSN: 1438-2199</identifier><identifier>DOI: 10.1007/s00726-005-0160-6</identifier><identifier>PMID: 15714256</identifier><language>eng</language><publisher>Austria: Springer Nature B.V</publisher><subject>Amino acids ; Anesthetics ; Anesthetics, Intravenous - administration & dosage ; Anesthetics, Intravenous - adverse effects ; Animals ; Behavior, Animal - drug effects ; Bicuculline - administration & dosage ; Bicuculline - adverse effects ; Brain Chemistry - drug effects ; Chromatography, High Pressure Liquid ; Dialysis - methods ; Dopamine ; Dopamine - metabolism ; Feedback ; GABA Antagonists - administration & dosage ; GABA Antagonists - adverse effects ; Glutamates ; Glutamic Acid - metabolism ; Hallucinations - chemically induced ; Male ; Medicin och hälsovetenskap ; Modulation ; Neurology ; Neurons - metabolism ; Nuclei ; Propofol - administration & dosage ; Propofol - adverse effects ; Rats ; Rats, Sprague-Dawley ; Receptors ; Rodents ; Sexual Dysfunctions, Psychological - chemically induced ; Telencephalon - metabolism</subject><ispartof>Amino acids, 2005-03, Vol.28 (2), p.145-148</ispartof><rights>Springer-Verlag/Wien 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-c8117ec77ede3de6eb5509067e3ee30354568444ed2e21a81a27cae45b0e325a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,309,310,314,780,784,789,790,885,23929,23930,25139,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15714256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1943917$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Grasshoff, C</creatorcontrib><creatorcontrib>Herrera-Marschitz, M</creatorcontrib><creatorcontrib>Goiny, M</creatorcontrib><creatorcontrib>Kretschmer, B D</creatorcontrib><title>Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis</title><title>Amino acids</title><addtitle>Amino Acids</addtitle><description>The intravenous anesthetic propofol is reported to have various psychological side effects as hallucinations, sexual disinhibition, or euphoria. Hedonic and rewarding states like these are modulated by the dopaminergic system in the nucleus accumbens, prefrontal cortex and also in the ventral pallidum and by the glutamatergic system in the neocortex and limbic system. In the present study, propofol was administered either alone or in combination with the GABAA receptor antagonist bicuculline via reverse microdialysis into the ventral pallidum of freely moving rats. Dialysis fractions were taken every 20 min and analyzed for dopamine and glutamate using high performance liquid chromatography. Application of propofol decreased dopamine levels in the ventral pallidum. This effect seems to be mainly mediated through GABAA receptors, since it was compensated by the GABAA receptor antagonist bicuculline. Propofol and propofol plus bicuculline exerted no effect on glutamate release in this brain region. The reduced dopamine release in ventral pallidum was most probably mediated through a GABAergic feedback loop from the ventral pallidum via the nucleus accumbens to the dopaminergic neurons of the ventral tegmental area or by long loop feedback. As an increase but not a decrease of dopamine release in the ventral pallidum is involved in hedonic and rewarding properties, similar symptoms induced by propofol seem to be unrelated to an action of propofol in the ventral pallidum.</description><subject>Amino acids</subject><subject>Anesthetics</subject><subject>Anesthetics, Intravenous - administration & dosage</subject><subject>Anesthetics, Intravenous - adverse effects</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Bicuculline - administration & dosage</subject><subject>Bicuculline - adverse effects</subject><subject>Brain Chemistry - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dialysis - methods</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Feedback</subject><subject>GABA Antagonists - administration & dosage</subject><subject>GABA Antagonists - adverse effects</subject><subject>Glutamates</subject><subject>Glutamic Acid - metabolism</subject><subject>Hallucinations - chemically induced</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Modulation</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Nuclei</subject><subject>Propofol - administration & dosage</subject><subject>Propofol - adverse effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors</subject><subject>Rodents</subject><subject>Sexual Dysfunctions, Psychological - chemically induced</subject><subject>Telencephalon - metabolism</subject><issn>0939-4451</issn><issn>1438-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1ks2KFTEQhYMoznX0AdxIwI2b1lR-O0sZ_BkYcaPrkO7U1YzpTtvpvnIfwPc2zb3OgOAmKYrvFJWTQ8hzYK-BMfOm1IPrhjHVMNCs0Q_IDqRoGw7WPiQ7ZoVtpFRwQZ6UcssY8Bb0Y3IByoDkSu_I7085rMkvMY807-kBx2X2iU4-pRhqEfLkhzgi9WOg39K6-MEvSGdM6AvS7kiX70jjpqravJYKYqm9JfZ0mvOU9znRsqwhYtjwONJDPGQ6xH7OIfp0LLE8JY_2PhV8dr4vydf3775cfWxuPn-4vnp70_QK-NL0LYDB3hgMKAJq7JRilmmDAlEwoaTSrZQSA0cOvgXPTe9Rqo6h4MqLS9Kc5pZfOK2dm-Y4-Pnoso_u3PpRK3Sq5Uy0lTf_5evjwr3orxCsFBZMVb46KSv2c62OuCGWHlOq9lSXHDCw2igmdEVf_oPe5nUeqw-VskobZgAqBSeq2lbKjPu7ZYC5LQ3ulAZX0-C2NLht8ovz5LUbMNwrzt8v_gAK0LPB</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Grasshoff, C</creator><creator>Herrera-Marschitz, M</creator><creator>Goiny, M</creator><creator>Kretschmer, B D</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>BNKNJ</scope></search><sort><creationdate>20050301</creationdate><title>Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis</title><author>Grasshoff, C ; Herrera-Marschitz, M ; Goiny, M ; Kretschmer, B D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-c8117ec77ede3de6eb5509067e3ee30354568444ed2e21a81a27cae45b0e325a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amino acids</topic><topic>Anesthetics</topic><topic>Anesthetics, Intravenous - 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chemically induced</topic><topic>Telencephalon - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grasshoff, C</creatorcontrib><creatorcontrib>Herrera-Marschitz, M</creatorcontrib><creatorcontrib>Goiny, M</creatorcontrib><creatorcontrib>Kretschmer, B D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SwePub Conference</collection><jtitle>Amino acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grasshoff, C</au><au>Herrera-Marschitz, M</au><au>Goiny, M</au><au>Kretschmer, B D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis</atitle><jtitle>Amino acids</jtitle><addtitle>Amino Acids</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>28</volume><issue>2</issue><spage>145</spage><epage>148</epage><pages>145-148</pages><issn>0939-4451</issn><eissn>1438-2199</eissn><abstract>The intravenous anesthetic propofol is reported to have various psychological side effects as hallucinations, sexual disinhibition, or euphoria. Hedonic and rewarding states like these are modulated by the dopaminergic system in the nucleus accumbens, prefrontal cortex and also in the ventral pallidum and by the glutamatergic system in the neocortex and limbic system. In the present study, propofol was administered either alone or in combination with the GABAA receptor antagonist bicuculline via reverse microdialysis into the ventral pallidum of freely moving rats. Dialysis fractions were taken every 20 min and analyzed for dopamine and glutamate using high performance liquid chromatography. Application of propofol decreased dopamine levels in the ventral pallidum. This effect seems to be mainly mediated through GABAA receptors, since it was compensated by the GABAA receptor antagonist bicuculline. Propofol and propofol plus bicuculline exerted no effect on glutamate release in this brain region. The reduced dopamine release in ventral pallidum was most probably mediated through a GABAergic feedback loop from the ventral pallidum via the nucleus accumbens to the dopaminergic neurons of the ventral tegmental area or by long loop feedback. As an increase but not a decrease of dopamine release in the ventral pallidum is involved in hedonic and rewarding properties, similar symptoms induced by propofol seem to be unrelated to an action of propofol in the ventral pallidum.</abstract><cop>Austria</cop><pub>Springer Nature B.V</pub><pmid>15714256</pmid><doi>10.1007/s00726-005-0160-6</doi><tpages>4</tpages></addata></record> |
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| ispartof | Amino acids, 2005-03, Vol.28 (2), p.145-148 |
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| language | eng |
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| subjects | Amino acids Anesthetics Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - adverse effects Animals Behavior, Animal - drug effects Bicuculline - administration & dosage Bicuculline - adverse effects Brain Chemistry - drug effects Chromatography, High Pressure Liquid Dialysis - methods Dopamine Dopamine - metabolism Feedback GABA Antagonists - administration & dosage GABA Antagonists - adverse effects Glutamates Glutamic Acid - metabolism Hallucinations - chemically induced Male Medicin och hälsovetenskap Modulation Neurology Neurons - metabolism Nuclei Propofol - administration & dosage Propofol - adverse effects Rats Rats, Sprague-Dawley Receptors Rodents Sexual Dysfunctions, Psychological - chemically induced Telencephalon - metabolism |
| title | Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis |
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