Kinase Domain of Titin Controls Muscle Gene Expression and Protein Turnover

The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to sense mechanical load. We identified a signaling complex where TK interacts with the zinc-finger protein nbr1 through a mechanically inducible conformation. Nbr1 targets the ubiquitin-associated p62/SQSTM1...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2005-06, Vol.308 (5728), p.1599-1603
Hauptverfasser:	Lange, Stephan, Xiang, Fengqing, Yakovenko, Andrey, Vihola, Anna, Hackman, Peter, Rostkova, Elena, Kristensen, Jakob, Brandmeier, Birgit, Franzen, Gereon, Hedberg, Birgitta, Gunnarsson, Lars Gunnar, Hughes, Simon M, Marchand, Sylvie, Sejersen, Thomas, Richard, Isabelle, Edström, Lars, Ehler, Elisabeth, Udd, Bjarne, Gautel, Mathias
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals Biological and medical sciences Catalytic Domain Cell Line Cell lines Cell Nucleus - metabolism Connectin Disease Gene expression Gene Expression Regulation General aspects Genes Genetic mutation Heat-Shock Proteins - metabolism Humans Individualized Instruction Interaction Process Analysis Intracellular Signaling Peptides and Proteins Ligands Medical sciences Mice Mice, Inbred C3H Molecular Sequence Data Muscle Proteins - chemistry Muscle Proteins - genetics Muscle Proteins - metabolism Muscle, Skeletal - metabolism Muscles Muscular diseases Muscular Diseases - genetics Muscular system Mutation Myocytes, Cardiac - metabolism Protein Binding Protein Conformation Protein Kinases - chemistry Protein Kinases - genetics Protein Kinases - metabolism Protein Structure, Tertiary Proteins Proteins - metabolism Rats Research Article Respiratory Insufficiency - genetics Respiratory Insufficiency - metabolism Sarcomeres Sarcomeres - metabolism Screening Tests Sequestosome-1 Protein Serum Response Factor - metabolism Signal Transduction Skeletal muscle Two-Hybrid System Techniques Ubiquitin-Protein Ligases - metabolism
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