Actions of adenosine at its receptors in the CNS: Insights from knockouts and drugs
Adenosine and its receptors have been the topic of many recent reviews. These reviews provide a good summary of much of the relevant literature--including the older literature. We have, therefore, chosen to focus the present review on the insights gained from recent studies on genetically modified m...
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| Veröffentlicht in: | Annual review of pharmacology and toxicology 2005-01, Vol.45 (1), p.385-412 |
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| creator | FREDHOLM, Bertil B CHEN, Jiang-Fan MASINO, Susan A VAUGEOIS, Jean-Marie |
| description | Adenosine and its receptors have been the topic of many recent reviews. These reviews provide a good summary of much of the relevant literature--including the older literature. We have, therefore, chosen to focus the present review on the insights gained from recent studies on genetically modified mice, particularly with respect to the function of adenosine receptors and their potential as therapeutic targets. The information gained from studies of drug effects is discussed in this context, and discrepancies between genetic and pharmacological results are highlighted. |
| doi_str_mv | 10.1146/annurev.pharmtox.45.120403.095731 |
| format | Article |
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Psychology ; Human health and pathology ; Humans ; Life Sciences ; Mice ; Mice, Knockout ; Molecular and cellular biology ; Nervous System Diseases - genetics ; Nervous System Diseases - metabolism ; Purinergic P1 Receptor Agonists ; Receptors, Purinergic P1 - genetics ; Receptors, Purinergic P1 - metabolism</subject><ispartof>Annual review of pharmacology and toxicology, 2005-01, Vol.45 (1), p.385-412</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Annual Reviews, Inc. 2005</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a620t-68f8e036249a5b5ab94fd63d9a250865a0a01cf8baf3b2cb1abca6bc4afda1503</citedby><cites>FETCH-LOGICAL-a620t-68f8e036249a5b5ab94fd63d9a250865a0a01cf8baf3b2cb1abca6bc4afda1503</cites><orcidid>0000-0001-8296-672X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,4168,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16564901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15822182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://normandie-univ.hal.science/hal-02185481$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1931937$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>FREDHOLM, Bertil B</creatorcontrib><creatorcontrib>CHEN, Jiang-Fan</creatorcontrib><creatorcontrib>MASINO, Susan A</creatorcontrib><creatorcontrib>VAUGEOIS, Jean-Marie</creatorcontrib><title>Actions of adenosine at its receptors in the CNS: Insights from knockouts and drugs</title><title>Annual review of pharmacology and toxicology</title><addtitle>Annu Rev Pharmacol Toxicol</addtitle><description>Adenosine and its receptors have been the topic of many recent reviews. 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Psychology</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Molecular and cellular biology</subject><subject>Nervous System Diseases - genetics</subject><subject>Nervous System Diseases - metabolism</subject><subject>Purinergic P1 Receptor Agonists</subject><subject>Receptors, Purinergic P1 - genetics</subject><subject>Receptors, Purinergic P1 - metabolism</subject><issn>0362-1642</issn><issn>1545-4304</issn><issn>0362-1642</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFks1u1DAURiMEokPhFZCFBFIXCf6Pw240AlppBIvC2rpxnE46iR3spNC3r0cJVLBhZfv66PPV9cmyC4ILQrh8D87Nwd4V4wHCMPlfBRcFoZhjVuBKlIw8yTZEcJFzhvnTbIOZpDmRnJ5lL2K8xRhXjJPn2RkRilKi6Ca73pqp8y4i3yJorPOxcxbBhLopomCNHScfIuocmg4W7b5cf0BXLnY3h3TdBj-go_Pm6Od0BNegJsw38WX2rIU-2lfrep59__Tx2-4y33_9fLXb7nOQFE-5VK2ypxZ5BaIWUFe8bSRrKqACKykAAyamVTW0rKamJlAbkLXh0DZABGbnWb7kxp92nGs9hm6AcK89dHotHdPOaqEIozTxFwt_gP4v-HK716caTjMRXJE7kth3CzsG_2O2cdJDF43te3DWz1HLsmRUleq_IClFSSmVCXzzD3jr5-DSgDTFQgkh6Cltu0Am-BiDbf_0SbA-OaBXB_RvBzQXenFALw6kjNfrQ3M92OYxYf30BLxdAYgG-jaAM1185KSQvMKEPQBXs7_b</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>FREDHOLM, Bertil B</creator><creator>CHEN, Jiang-Fan</creator><creator>MASINO, Susan A</creator><creator>VAUGEOIS, Jean-Marie</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0001-8296-672X</orcidid></search><sort><creationdate>20050101</creationdate><title>Actions of adenosine at its receptors in the CNS: Insights from knockouts and drugs</title><author>FREDHOLM, Bertil B ; CHEN, Jiang-Fan ; MASINO, Susan A ; VAUGEOIS, Jean-Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a620t-68f8e036249a5b5ab94fd63d9a250865a0a01cf8baf3b2cb1abca6bc4afda1503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adenosine - metabolism</topic><topic>Adenosine - pharmacology</topic><topic>Adenosinic and purinergic receptors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Central Nervous System - drug effects</topic><topic>Central Nervous System - metabolism</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Annual review of pharmacology and toxicology, 2005-01, Vol.45 (1), p.385-412 |
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| language | eng |
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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Adenosine - metabolism Adenosine - pharmacology Adenosinic and purinergic receptors Animals Biological and medical sciences Cell receptors Cell structures and functions Central Nervous System - drug effects Central Nervous System - metabolism Fundamental and applied biological sciences. Psychology Human health and pathology Humans Life Sciences Mice Mice, Knockout Molecular and cellular biology Nervous System Diseases - genetics Nervous System Diseases - metabolism Purinergic P1 Receptor Agonists Receptors, Purinergic P1 - genetics Receptors, Purinergic P1 - metabolism |
| title | Actions of adenosine at its receptors in the CNS: Insights from knockouts and drugs |
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