Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim

Mast cells are found in tissues throughout the body where they play important roles in the regulation of inflammatory responses. One characteristic feature of mast cells is their longevity. Although it is well established that mast cell survival is dependent on stem cell factor (SCF), it has not bee...

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Veröffentlicht in:	Blood 2005-08, Vol.106 (4), p.1330-1336
Hauptverfasser:	Möller, Christine, Alfredsson, Jessica, Engström, Maria, Wootz, Hanna, Xiang, Zou, Lennartsson, Johan, Jönsson, Jan-Ingvar, Nilsson, Gunnar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Biological and medical sciences Carrier Proteins - metabolism Cell Survival Clinical Medicine Forkhead Box Protein O3 Forkhead Transcription Factors Fundamental and applied biological sciences. Psychology Fundamental immunology Hematologi Hematology Immunobiology Klinisk medicin Mast Cells - cytology Medical and Health Sciences MEDICIN Medicin och hälsovetenskap MEDICINE Membrane Proteins - metabolism Mice Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism Modulation of the immune response (stimulation, suppression) Phosphorylation Proto-Oncogene Proteins - metabolism Stem Cell Factor - physiology Transcription Factors - physiology Transcription, Genetic
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