Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses

Cyclin-dependent kinase 5 (Cdk5) has emerged as a key coordinator of cell signaling in neurite outgrowth. Cdk5 needs to associate with one of the regulatory proteins p35 or p39 to be an active enzyme. To investigate if Cdk5 plays a role in the establishment of functional synapses, we have characteri...

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Veröffentlicht in:	Brain research. Molecular brain research. 2005-08, Vol.138 (2), p.215-227
Hauptverfasser:	Johansson, Jenny U., Lilja, Lena, Chen, Xiao-Liang, Higashida, Haruhiro, Meister, Björn, Noda, Mami, Zhong, Zhen-Guo, Yokoyama, Shigeru, Berggren, Per-Olof, Bark, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Animals Biological and medical sciences Cell Differentiation - physiology Cell Line, Tumor Cell Membrane - enzymology Cellular differentiation Central Nervous System - embryology Central Nervous System - enzymology Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Cytoskeleton - enzymology Enzyme Activation - physiology Fundamental and applied biological sciences. Psychology Hybrid cell Medicin och hälsovetenskap Mice Miniature endplate potential Muscle Fibers, Skeletal - enzymology Myotube Nerve Tissue Proteins - metabolism Neural Pathways - embryology Neural Pathways - enzymology Neuromuscular Junction - embryology Neuromuscular Junction - enzymology Rats Synapses - enzymology Synaptic Transmission - genetics Synaptogenesis Up-Regulation - physiology Vertebrates: nervous system and sense organs
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