Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia

The cellular targets of primary mutations and malignant transformation remain elusive in most cancers. Here, we show that clinically and genetically different subtypes of acute lymphoblastic leukemia (ALL) originate and transform at distinct stages of hematopoietic development. Primary ETV6-RUNX1 (a...

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Veröffentlicht in:	Nature medicine 2005-06, Vol.11 (6), p.630-637
Hauptverfasser:	Castor, Anders, Nilsson, Lars, Åstrand-Grundström, Ingbritt, Buitenhuis, Miranda, Ramirez, Carole, Anderson, Kristina, Strömbeck, Bodil, Garwicz, Stanislaw, Békássy, Albert N, Schmiegelow, Kjeld, Lausen, Birgitte, Hokland, Peter, Lehmann, Sören, Juliusson, Gunnar, Johansson, Bertil, Jacobsen, Sten Eirik W
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase ADP-ribosyl Cyclase 1 Adult Antigens, CD Antigens, CD19 Antigens, CD34 Basic Medicine Biomedical and Life Sciences Biomedicine Cancer Research Cell and Molecular Biology Cell- och molekylärbiologi Child Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 21 Clinical Medicine Core Binding Factor Alpha 2 Subunit DNA-Binding Proteins - physiology ETS Translocation Variant 6 Protein Flow Cytometry Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - physiology Hematopoietic Stem Cells - physiology Humans Infectious Diseases Klinisk medicin Leukemia Medical and Health Sciences Medical Genetics MEDICIN Medicin och hälsovetenskap MEDICINE Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Membrane Glycoproteins Metabolic Diseases Molecular Medicine Mutation Neurosciences Nuclear Proteins - physiology Oncogene Proteins, Fusion - physiology Pediatrics Pediatrik Phenotype Precursor Cell Lymphoblastic Leukemia-Lymphoma - classification Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Proto-Oncogene Proteins c-ets Repressor Proteins - physiology Stem cells Translocation, Genetic
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