Gene expression changes in brains of mice exposed to a maternal virus infection
In this study, we tested the hypothesis that exposure to a maternal infection during fetal life can lead to the appearance of alterations in the brain later in life. C57BL/6 mice were infected intranasally with influenza A/WSN/33 virus on day 14 of gestation. The levels of transcripts encoding neuro...
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| Veröffentlicht in: | Neuroreport 2005-07, Vol.16 (10), p.1111-1115 |
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| creator | Asp, Linnéa Beraki, Simret Aronsson, Fredrik Rosvall, Lina Ögren, Sven Ove Kristensson, Krister Karlsson, Håkan |
| description | In this study, we tested the hypothesis that exposure to a maternal infection during fetal life can lead to the appearance of alterations in the brain later in life. C57BL/6 mice were infected intranasally with influenza A/WSN/33 virus on day 14 of gestation. The levels of transcripts encoding neuroleukin and fibroblast growth factor 5 were significantly elevated in the brains of the virus-exposed offspring at 90 and 280 days of age, but not at earlier time-points. For neuroleukin, this difference could also be observed at the protein level. Thus, a maternal influenza A virus infection can give rise to alterations in gene expression in the brain that become apparent only after a prepubertal latency period. |
| doi_str_mv | 10.1097/00001756-200507130-00016 |
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C57BL/6 mice were infected intranasally with influenza A/WSN/33 virus on day 14 of gestation. The levels of transcripts encoding neuroleukin and fibroblast growth factor 5 were significantly elevated in the brains of the virus-exposed offspring at 90 and 280 days of age, but not at earlier time-points. For neuroleukin, this difference could also be observed at the protein level. Thus, a maternal influenza A virus infection can give rise to alterations in gene expression in the brain that become apparent only after a prepubertal latency period.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200507130-00016</identifier><identifier>PMID: 15973158</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Biological and medical sciences ; Brain - metabolism ; Brain - virology ; Central Nervous System Viral Diseases - metabolism ; Central Nervous System Viral Diseases - virology ; Development. Senescence. Regeneration. Transplantation ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Developmental - physiology ; Humans ; Influenza A virus ; Influenza A virus - genetics ; Influenza A virus - metabolism ; Influenza, Human - genetics ; Influenza, Human - metabolism ; Maternal Exposure ; Medicin och hälsovetenskap ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Prenatal Exposure Delayed Effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2005-07, Vol.16 (10), p.1111-1115</ispartof><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5736-e62bf9331d667c6044a065ba3b419946188b6d2f15444d42ab3a3a97b731fb063</citedby><cites>FETCH-LOGICAL-c5736-e62bf9331d667c6044a065ba3b419946188b6d2f15444d42ab3a3a97b731fb063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16916097$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15973158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:111315570$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Asp, Linnéa</creatorcontrib><creatorcontrib>Beraki, Simret</creatorcontrib><creatorcontrib>Aronsson, Fredrik</creatorcontrib><creatorcontrib>Rosvall, Lina</creatorcontrib><creatorcontrib>Ögren, Sven Ove</creatorcontrib><creatorcontrib>Kristensson, Krister</creatorcontrib><creatorcontrib>Karlsson, Håkan</creatorcontrib><title>Gene expression changes in brains of mice exposed to a maternal virus infection</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>In this study, we tested the hypothesis that exposure to a maternal infection during fetal life can lead to the appearance of alterations in the brain later in life. C57BL/6 mice were infected intranasally with influenza A/WSN/33 virus on day 14 of gestation. The levels of transcripts encoding neuroleukin and fibroblast growth factor 5 were significantly elevated in the brains of the virus-exposed offspring at 90 and 280 days of age, but not at earlier time-points. For neuroleukin, this difference could also be observed at the protein level. Thus, a maternal influenza A virus infection can give rise to alterations in gene expression in the brain that become apparent only after a prepubertal latency period.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - virology</subject><subject>Central Nervous System Viral Diseases - metabolism</subject><subject>Central Nervous System Viral Diseases - virology</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Humans</subject><subject>Influenza A virus</subject><subject>Influenza A virus - genetics</subject><subject>Influenza A virus - metabolism</subject><subject>Influenza, Human - genetics</subject><subject>Influenza, Human - metabolism</subject><subject>Maternal Exposure</subject><subject>Medicin och hälsovetenskap</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ks1u3CAURlHUKJmmfYWKTbtzCubPLKuoTSNFyqaVskOArzs0tpmC3UnfvjjjZFZhA7o6h3vFB0KYkktKtPpMyqJKyKomRBBFGamWijxBG8oVq4Ro7t-gDdFCV1xLcY7e5vy7IJrQ5gydU6EVo6LZoLtrGAHD4y5BziGO2G_t-AsyDiN2yYYx49jhIfgnKGZo8RSxxYOdII22x39Dmhe6Az8V_x067Wyf4f26X6Cf377-uPpe3d5d31x9ua28UExWIGvXacZoK6XyknBuiRTOMsep1lzSpnGyrTsqOOctr61jllmtXBm7c0SyC1Qd7s172M3O7FIYbPpnog1mLT2UExjRkJqxwutX-V2K7VF6Fiml5YmEIsX9dHAL-GeGPJkhZA99b0eIczb1kgHhy1DNAfQp5pyge2lDiVmCM8_BmZfgzFNwRf2w9pjdAO1RXJMqwMcVsNnbvkt29CEfOampLB0Kxw_cPvYlovzQz3tIZgu2n7bmtY_D_gPHnbAj</recordid><startdate>20050713</startdate><enddate>20050713</enddate><creator>Asp, Linnéa</creator><creator>Beraki, Simret</creator><creator>Aronsson, Fredrik</creator><creator>Rosvall, Lina</creator><creator>Ögren, Sven Ove</creator><creator>Kristensson, Krister</creator><creator>Karlsson, Håkan</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20050713</creationdate><title>Gene expression changes in brains of mice exposed to a maternal virus infection</title><author>Asp, Linnéa ; Beraki, Simret ; Aronsson, Fredrik ; Rosvall, Lina ; Ögren, Sven Ove ; Kristensson, Krister ; Karlsson, Håkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5736-e62bf9331d667c6044a065ba3b419946188b6d2f15444d42ab3a3a97b731fb063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - virology</topic><topic>Central Nervous System Viral Diseases - metabolism</topic><topic>Central Nervous System Viral Diseases - virology</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Humans</topic><topic>Influenza A virus</topic><topic>Influenza A virus - genetics</topic><topic>Influenza A virus - metabolism</topic><topic>Influenza, Human - genetics</topic><topic>Influenza, Human - metabolism</topic><topic>Maternal Exposure</topic><topic>Medicin och hälsovetenskap</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asp, Linnéa</creatorcontrib><creatorcontrib>Beraki, Simret</creatorcontrib><creatorcontrib>Aronsson, Fredrik</creatorcontrib><creatorcontrib>Rosvall, Lina</creatorcontrib><creatorcontrib>Ögren, Sven Ove</creatorcontrib><creatorcontrib>Kristensson, Krister</creatorcontrib><creatorcontrib>Karlsson, Håkan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asp, Linnéa</au><au>Beraki, Simret</au><au>Aronsson, Fredrik</au><au>Rosvall, Lina</au><au>Ögren, Sven Ove</au><au>Kristensson, Krister</au><au>Karlsson, Håkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene expression changes in brains of mice exposed to a maternal virus infection</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2005-07-13</date><risdate>2005</risdate><volume>16</volume><issue>10</issue><spage>1111</spage><epage>1115</epage><pages>1111-1115</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>In this study, we tested the hypothesis that exposure to a maternal infection during fetal life can lead to the appearance of alterations in the brain later in life. C57BL/6 mice were infected intranasally with influenza A/WSN/33 virus on day 14 of gestation. The levels of transcripts encoding neuroleukin and fibroblast growth factor 5 were significantly elevated in the brains of the virus-exposed offspring at 90 and 280 days of age, but not at earlier time-points. For neuroleukin, this difference could also be observed at the protein level. Thus, a maternal influenza A virus infection can give rise to alterations in gene expression in the brain that become apparent only after a prepubertal latency period.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15973158</pmid><doi>10.1097/00001756-200507130-00016</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Brain - metabolism Brain - virology Central Nervous System Viral Diseases - metabolism Central Nervous System Viral Diseases - virology Development. Senescence. Regeneration. Transplantation Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - physiology Humans Influenza A virus Influenza A virus - genetics Influenza A virus - metabolism Influenza, Human - genetics Influenza, Human - metabolism Maternal Exposure Medicin och hälsovetenskap Mice Mice, Inbred C57BL Pregnancy Prenatal Exposure Delayed Effects Vertebrates: nervous system and sense organs |
| title | Gene expression changes in brains of mice exposed to a maternal virus infection |
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