Passive IgE‐sensitization by blood transfusion
Background: To study the mechanisms of passive sensitization of patients receiving plasma containing IgE antibodies to a defined allergen. Methods: When required for medical reasons, regular donor plasma with IgE antibodies to timothy grass allergen (8–205 kUA/l), was given. Kinetics of IgE antibo...
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| Veröffentlicht in: | Allergy (Copenhagen) 2005-09, Vol.60 (9), p.1192-1199 |
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| creator | Johansson, S. G. O. Nopp, A. Hage, M. Olofsson, N. Lundahl, J. Wehlin, L. Söderström, L. Stiller, V. Öman, H. |
| description | Background: To study the mechanisms of passive sensitization of patients receiving plasma containing IgE antibodies to a defined allergen.
Methods: When required for medical reasons, regular donor plasma with IgE antibodies to timothy grass allergen (8–205 kUA/l), was given. Kinetics of IgE antibodies in the recipients’ serum and his/her basophil allergen threshold sensitivity, CD‐sens, was monitored up to 2–3 weeks after transfusion. The IgE antibodies were quantitated by ImmunoCAP. The CD‐sens in plasma recipients, determined by CD63 up‐regulation, was measured by flow cytometry and compared to CD‐sens of patients with allergic asthma and/or rhinitis.
Results: There was a significant correlation (r = 0.98; P |
| doi_str_mv | 10.1111/j.1398-9995.2005.00870.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_579657</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68439614</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5790-59bd82ad06a0873c0ae6bee99f5aa60627ec5ebe1c7dc875e70e46f42156d6af3</originalsourceid><addsrcrecordid>eNqNkc9u1DAQxi1ERZfCK6Bc4JZ0HMf_JC5VVaDSSvQAZ8txJshLdrNkNrTbE4_AM_IkON3QPSHwxaOZ3zfzSR9jGYeCp3e-KriwJrfWyqIEkAWA0VDcPWGLx8FTtgAOMq-kMKfsOdEKAHRp4Rk75Qq0EqAXDG48UfyO2fWXq18_fhJuKO7ivd_FfpPV-6zu-r7JdoPfUDtSar5gJ63vCF_O_xn7_O7q0-WHfPnx_fXlxTIPUlvIpa0bU_oGlE_WRACPqka0tpXeK1ClxiCxRh50E4yWqAEr1VYll6pRvhVnLD_spVvcjrXbDnHth73rfXRz62uq0KVzSurE67_y26FvjqI_Qm6lBmGS8s1BmbBvI9LOrSMF7Dq_wX4kp0wlrOLVP0GuhSllNXkxBzAMPdGA7aMbDm4K0K3clJObcnJTgO4hQHeXpK_mG2O9xuYonBNLwOsZ8BR816ZkQqQjp9MmpSezbw_cbexw_98G3MVymQrxG0liuI0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17382547</pqid></control><display><type>article</type><title>Passive IgE‐sensitization by blood transfusion</title><source>MEDLINE</source><source>Wiley Journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Johansson, S. G. O. ; Nopp, A. ; Hage, M. ; Olofsson, N. ; Lundahl, J. ; Wehlin, L. ; Söderström, L. ; Stiller, V. ; Öman, H.</creator><creatorcontrib>Johansson, S. G. O. ; Nopp, A. ; Hage, M. ; Olofsson, N. ; Lundahl, J. ; Wehlin, L. ; Söderström, L. ; Stiller, V. ; Öman, H.</creatorcontrib><description>Background: To study the mechanisms of passive sensitization of patients receiving plasma containing IgE antibodies to a defined allergen.
Methods: When required for medical reasons, regular donor plasma with IgE antibodies to timothy grass allergen (8–205 kUA/l), was given. Kinetics of IgE antibodies in the recipients’ serum and his/her basophil allergen threshold sensitivity, CD‐sens, was monitored up to 2–3 weeks after transfusion. The IgE antibodies were quantitated by ImmunoCAP. The CD‐sens in plasma recipients, determined by CD63 up‐regulation, was measured by flow cytometry and compared to CD‐sens of patients with allergic asthma and/or rhinitis.
Results: There was a significant correlation (r = 0.98; P < 0.001) between amount of IgE antibody given and recipient serum peak concentration. The T1/2 for IgE antibody in circulation was 1.13 days (95% confidence limit 0.35–1.91 days). The recipients became CD‐sens positive already 3 h after transfusion. The CD‐sens peak was observed after 3.4 days and the value were correlated (r = 0.68; P < 0.02) to the amount of IgE antibody transfused and were of the same magnitude as found in allergic patients. The T1/2 of CD‐sens indicated two populations of basophils; one with a CD‐sens decrease T1/2 of 4 days and one of 10 days.
Conclusion: Transfused IgE antibodies will sensitize mast cells and basophils to CD‐sens levels similar to those of allergic patients. The recipients expressed ‘slow’ or ‘rapid’ CD‐sens decline, indicating two different basophil populations. After transfusion of plasma with >10 kUA/l IgE antibody the recipient could have allergen reactive basophils for up to 7 weeks.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/j.1398-9995.2005.00870.x</identifier><identifier>PMID: 16076307</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Allergens - immunology ; Allergic diseases ; allergy ; basophils ; Basophils - immunology ; Biological and medical sciences ; Blood Transfusion ; CD63 ; Conjunctivitis, Allergic - immunology ; flow cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; IgE antibody ; Immunization, Passive ; Immunoglobulin E - immunology ; Immunologic Tests ; Immunopathology ; Mast Cells - immunology ; Medical sciences ; Medicin och hälsovetenskap ; Phleum - immunology ; Respiratory Hypersensitivity - immunology</subject><ispartof>Allergy (Copenhagen), 2005-09, Vol.60 (9), p.1192-1199</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5790-59bd82ad06a0873c0ae6bee99f5aa60627ec5ebe1c7dc875e70e46f42156d6af3</citedby><cites>FETCH-LOGICAL-c5790-59bd82ad06a0873c0ae6bee99f5aa60627ec5ebe1c7dc875e70e46f42156d6af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1398-9995.2005.00870.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1398-9995.2005.00870.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,782,786,887,1419,1435,27931,27932,45581,45582,46416,46840</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17008674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16076307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1957038$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Johansson, S. G. O.</creatorcontrib><creatorcontrib>Nopp, A.</creatorcontrib><creatorcontrib>Hage, M.</creatorcontrib><creatorcontrib>Olofsson, N.</creatorcontrib><creatorcontrib>Lundahl, J.</creatorcontrib><creatorcontrib>Wehlin, L.</creatorcontrib><creatorcontrib>Söderström, L.</creatorcontrib><creatorcontrib>Stiller, V.</creatorcontrib><creatorcontrib>Öman, H.</creatorcontrib><title>Passive IgE‐sensitization by blood transfusion</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background: To study the mechanisms of passive sensitization of patients receiving plasma containing IgE antibodies to a defined allergen.
Methods: When required for medical reasons, regular donor plasma with IgE antibodies to timothy grass allergen (8–205 kUA/l), was given. Kinetics of IgE antibodies in the recipients’ serum and his/her basophil allergen threshold sensitivity, CD‐sens, was monitored up to 2–3 weeks after transfusion. The IgE antibodies were quantitated by ImmunoCAP. The CD‐sens in plasma recipients, determined by CD63 up‐regulation, was measured by flow cytometry and compared to CD‐sens of patients with allergic asthma and/or rhinitis.
Results: There was a significant correlation (r = 0.98; P < 0.001) between amount of IgE antibody given and recipient serum peak concentration. The T1/2 for IgE antibody in circulation was 1.13 days (95% confidence limit 0.35–1.91 days). The recipients became CD‐sens positive already 3 h after transfusion. The CD‐sens peak was observed after 3.4 days and the value were correlated (r = 0.68; P < 0.02) to the amount of IgE antibody transfused and were of the same magnitude as found in allergic patients. The T1/2 of CD‐sens indicated two populations of basophils; one with a CD‐sens decrease T1/2 of 4 days and one of 10 days.
Conclusion: Transfused IgE antibodies will sensitize mast cells and basophils to CD‐sens levels similar to those of allergic patients. The recipients expressed ‘slow’ or ‘rapid’ CD‐sens decline, indicating two different basophil populations. After transfusion of plasma with >10 kUA/l IgE antibody the recipient could have allergen reactive basophils for up to 7 weeks.</description><subject>Allergens - immunology</subject><subject>Allergic diseases</subject><subject>allergy</subject><subject>basophils</subject><subject>Basophils - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion</subject><subject>CD63</subject><subject>Conjunctivitis, Allergic - immunology</subject><subject>flow cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>IgE antibody</subject><subject>Immunization, Passive</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunologic Tests</subject><subject>Immunopathology</subject><subject>Mast Cells - immunology</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Phleum - immunology</subject><subject>Respiratory Hypersensitivity - immunology</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxi1ERZfCK6Bc4JZ0HMf_JC5VVaDSSvQAZ8txJshLdrNkNrTbE4_AM_IkON3QPSHwxaOZ3zfzSR9jGYeCp3e-KriwJrfWyqIEkAWA0VDcPWGLx8FTtgAOMq-kMKfsOdEKAHRp4Rk75Qq0EqAXDG48UfyO2fWXq18_fhJuKO7ivd_FfpPV-6zu-r7JdoPfUDtSar5gJ63vCF_O_xn7_O7q0-WHfPnx_fXlxTIPUlvIpa0bU_oGlE_WRACPqka0tpXeK1ClxiCxRh50E4yWqAEr1VYll6pRvhVnLD_spVvcjrXbDnHth73rfXRz62uq0KVzSurE67_y26FvjqI_Qm6lBmGS8s1BmbBvI9LOrSMF7Dq_wX4kp0wlrOLVP0GuhSllNXkxBzAMPdGA7aMbDm4K0K3clJObcnJTgO4hQHeXpK_mG2O9xuYonBNLwOsZ8BR816ZkQqQjp9MmpSezbw_cbexw_98G3MVymQrxG0liuI0</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Johansson, S. G. O.</creator><creator>Nopp, A.</creator><creator>Hage, M.</creator><creator>Olofsson, N.</creator><creator>Lundahl, J.</creator><creator>Wehlin, L.</creator><creator>Söderström, L.</creator><creator>Stiller, V.</creator><creator>Öman, H.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>200509</creationdate><title>Passive IgE‐sensitization by blood transfusion</title><author>Johansson, S. G. O. ; Nopp, A. ; Hage, M. ; Olofsson, N. ; Lundahl, J. ; Wehlin, L. ; Söderström, L. ; Stiller, V. ; Öman, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5790-59bd82ad06a0873c0ae6bee99f5aa60627ec5ebe1c7dc875e70e46f42156d6af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Allergens - immunology</topic><topic>Allergic diseases</topic><topic>allergy</topic><topic>basophils</topic><topic>Basophils - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion</topic><topic>CD63</topic><topic>Conjunctivitis, Allergic - immunology</topic><topic>flow cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>IgE antibody</topic><topic>Immunization, Passive</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunologic Tests</topic><topic>Immunopathology</topic><topic>Mast Cells - immunology</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Phleum - immunology</topic><topic>Respiratory Hypersensitivity - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johansson, S. G. O.</creatorcontrib><creatorcontrib>Nopp, A.</creatorcontrib><creatorcontrib>Hage, M.</creatorcontrib><creatorcontrib>Olofsson, N.</creatorcontrib><creatorcontrib>Lundahl, J.</creatorcontrib><creatorcontrib>Wehlin, L.</creatorcontrib><creatorcontrib>Söderström, L.</creatorcontrib><creatorcontrib>Stiller, V.</creatorcontrib><creatorcontrib>Öman, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johansson, S. G. O.</au><au>Nopp, A.</au><au>Hage, M.</au><au>Olofsson, N.</au><au>Lundahl, J.</au><au>Wehlin, L.</au><au>Söderström, L.</au><au>Stiller, V.</au><au>Öman, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Passive IgE‐sensitization by blood transfusion</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2005-09</date><risdate>2005</risdate><volume>60</volume><issue>9</issue><spage>1192</spage><epage>1199</epage><pages>1192-1199</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><coden>LLRGDY</coden><abstract>Background: To study the mechanisms of passive sensitization of patients receiving plasma containing IgE antibodies to a defined allergen.
Methods: When required for medical reasons, regular donor plasma with IgE antibodies to timothy grass allergen (8–205 kUA/l), was given. Kinetics of IgE antibodies in the recipients’ serum and his/her basophil allergen threshold sensitivity, CD‐sens, was monitored up to 2–3 weeks after transfusion. The IgE antibodies were quantitated by ImmunoCAP. The CD‐sens in plasma recipients, determined by CD63 up‐regulation, was measured by flow cytometry and compared to CD‐sens of patients with allergic asthma and/or rhinitis.
Results: There was a significant correlation (r = 0.98; P < 0.001) between amount of IgE antibody given and recipient serum peak concentration. The T1/2 for IgE antibody in circulation was 1.13 days (95% confidence limit 0.35–1.91 days). The recipients became CD‐sens positive already 3 h after transfusion. The CD‐sens peak was observed after 3.4 days and the value were correlated (r = 0.68; P < 0.02) to the amount of IgE antibody transfused and were of the same magnitude as found in allergic patients. The T1/2 of CD‐sens indicated two populations of basophils; one with a CD‐sens decrease T1/2 of 4 days and one of 10 days.
Conclusion: Transfused IgE antibodies will sensitize mast cells and basophils to CD‐sens levels similar to those of allergic patients. The recipients expressed ‘slow’ or ‘rapid’ CD‐sens decline, indicating two different basophil populations. After transfusion of plasma with >10 kUA/l IgE antibody the recipient could have allergen reactive basophils for up to 7 weeks.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>16076307</pmid><doi>10.1111/j.1398-9995.2005.00870.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Allergens - immunology Allergic diseases allergy basophils Basophils - immunology Biological and medical sciences Blood Transfusion CD63 Conjunctivitis, Allergic - immunology flow cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IgE antibody Immunization, Passive Immunoglobulin E - immunology Immunologic Tests Immunopathology Mast Cells - immunology Medical sciences Medicin och hälsovetenskap Phleum - immunology Respiratory Hypersensitivity - immunology |
| title | Passive IgE‐sensitization by blood transfusion |
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