Increased levels of APRIL (A Proliferation-Inducing Ligand) mRNA in multiple sclerosis

B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL–a promotor of B-cell survival–in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls. APRIL mRNA levels in monocyt...

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Veröffentlicht in:	Journal of neuroimmunology 2005-10, Vol.167 (1), p.210-214
Hauptverfasser:	Thangarajh, Mathula, Masterman, Thomas, Rot, Uroš, Duvefelt, Kristina, Brynedal, Boel, Karrenbauer, Virginija Danylaité, Hillert, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged APRIL B cells B-Lymphocytes - metabolism Blotting, Western - methods Cell Count - methods Child Child, Preschool Female Gene Expression Regulation - physiology Humans Infant Infant, Newborn Leukocytes - metabolism Male Membrane Proteins - blood Membrane Proteins - cerebrospinal fluid Membrane Proteins - genetics Middle Aged Multiple sclerosis Multiple Sclerosis - classification Multiple Sclerosis - genetics Multiple Sclerosis - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism Tumor Necrosis Factor Ligand Superfamily Member 13 Tumor Necrosis Factor-alpha - cerebrospinal fluid Tumor Necrosis Factor-alpha - genetics X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism
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