Increased levels of APRIL (A Proliferation-Inducing Ligand) mRNA in multiple sclerosis
B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL–a promotor of B-cell survival–in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls. APRIL mRNA levels in monocyt...
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| Veröffentlicht in: | Journal of neuroimmunology 2005-10, Vol.167 (1), p.210-214 |
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| container_title | Journal of neuroimmunology |
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| creator | Thangarajh, Mathula Masterman, Thomas Rot, Uroš Duvefelt, Kristina Brynedal, Boel Karrenbauer, Virginija Danylaité Hillert, Jan |
| description | B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL–a promotor of B-cell survival–in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls.
APRIL mRNA levels in monocytes and T cells were significantly higher in MS patients than in controls. Levels of soluble APRIL in plasma were higher in patients with chronic progressive MS than in patients with relapsing–remitting MS, albeit not significantly.
MS may thus be associated with increased transcription in peripheral blood of factors promoting B-cell survival, including APRIL. |
| doi_str_mv | 10.1016/j.jneuroim.2005.06.024 |
| format | Article |
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APRIL mRNA levels in monocytes and T cells were significantly higher in MS patients than in controls. Levels of soluble APRIL in plasma were higher in patients with chronic progressive MS than in patients with relapsing–remitting MS, albeit not significantly.
MS may thus be associated with increased transcription in peripheral blood of factors promoting B-cell survival, including APRIL.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2005.06.024</identifier><identifier>PMID: 16087247</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; APRIL ; B cells ; B-Lymphocytes - metabolism ; Blotting, Western - methods ; Cell Count - methods ; Child ; Child, Preschool ; Female ; Gene Expression Regulation - physiology ; Humans ; Infant ; Infant, Newborn ; Leukocytes - metabolism ; Male ; Membrane Proteins - blood ; Membrane Proteins - cerebrospinal fluid ; Membrane Proteins - genetics ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - classification ; Multiple Sclerosis - genetics ; Multiple Sclerosis - metabolism ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - metabolism ; Tumor Necrosis Factor Ligand Superfamily Member 13 ; Tumor Necrosis Factor-alpha - cerebrospinal fluid ; Tumor Necrosis Factor-alpha - genetics ; X-Linked Inhibitor of Apoptosis Protein - genetics ; X-Linked Inhibitor of Apoptosis Protein - metabolism</subject><ispartof>Journal of neuroimmunology, 2005-10, Vol.167 (1), p.210-214</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-d841aa4a8655bc39e706cdbb5e258d9ccf61620111ef48a63734cec72d1467513</citedby><cites>FETCH-LOGICAL-c501t-d841aa4a8655bc39e706cdbb5e258d9ccf61620111ef48a63734cec72d1467513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572805002754$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16087247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1938050$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Thangarajh, Mathula</creatorcontrib><creatorcontrib>Masterman, Thomas</creatorcontrib><creatorcontrib>Rot, Uroš</creatorcontrib><creatorcontrib>Duvefelt, Kristina</creatorcontrib><creatorcontrib>Brynedal, Boel</creatorcontrib><creatorcontrib>Karrenbauer, Virginija Danylaité</creatorcontrib><creatorcontrib>Hillert, Jan</creatorcontrib><title>Increased levels of APRIL (A Proliferation-Inducing Ligand) mRNA in multiple sclerosis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL–a promotor of B-cell survival–in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls.
APRIL mRNA levels in monocytes and T cells were significantly higher in MS patients than in controls. Levels of soluble APRIL in plasma were higher in patients with chronic progressive MS than in patients with relapsing–remitting MS, albeit not significantly.
MS may thus be associated with increased transcription in peripheral blood of factors promoting B-cell survival, including APRIL.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>APRIL</subject><subject>B cells</subject><subject>B-Lymphocytes - metabolism</subject><subject>Blotting, Western - methods</subject><subject>Cell Count - methods</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Gene Expression Regulation - physiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Membrane Proteins - blood</subject><subject>Membrane Proteins - cerebrospinal fluid</subject><subject>Membrane Proteins - genetics</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - classification</subject><subject>Multiple Sclerosis - genetics</subject><subject>Multiple Sclerosis - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - metabolism</subject><subject>Tumor Necrosis Factor Ligand Superfamily Member 13</subject><subject>Tumor Necrosis Factor-alpha - cerebrospinal fluid</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>X-Linked Inhibitor of Apoptosis Protein - genetics</subject><subject>X-Linked Inhibitor of Apoptosis Protein - metabolism</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAQgC1ERZeWv1D5hOCQYDt-5caqKrDSilZV4Wo59qTykjiLnRTx7_FqFzj2NKPRNy99CF1RUlNC5YddvYuwpCmMNSNE1ETWhPEXaEW1YpXmjL5EqwKKSiimz9HrnHeEUNHw9hU6p5IUjKsV-r6JLoHN4PEATzBkPPV4fXe_2eJ3a3yXpiH0kOwcplhtol9ciI94Gx5t9O_xeP91jUPE4zLMYT8Azm6ANOWQL9FZb4cMb07xAn37dPNw_aXa3n7eXK-3lROEzpXXnFrLrZZCdK5pQRHpfNcJYEL71rleUskIpRR6rq1sVMMdOMU85VIJ2lyg6jg3_4L90pl9CqNNv81kgzmVfpQMjFCtUAf-7ZHfp-nnAnk2Y8gOhsFGmJZspBaiaVr2LEhVo7WUooDyCLryeE7Q_7uBEnNQZXbmrypzUGWINEVVabw6bVi6Efz_tpObAnw8AsUKPAVIJrsA0YEPCdxs_BSe2_EHLimoBw</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Thangarajh, Mathula</creator><creator>Masterman, Thomas</creator><creator>Rot, Uroš</creator><creator>Duvefelt, Kristina</creator><creator>Brynedal, Boel</creator><creator>Karrenbauer, Virginija Danylaité</creator><creator>Hillert, Jan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20051001</creationdate><title>Increased levels of APRIL (A Proliferation-Inducing Ligand) mRNA in multiple sclerosis</title><author>Thangarajh, Mathula ; Masterman, Thomas ; Rot, Uroš ; Duvefelt, Kristina ; Brynedal, Boel ; Karrenbauer, Virginija Danylaité ; Hillert, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-d841aa4a8655bc39e706cdbb5e258d9ccf61620111ef48a63734cec72d1467513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>APRIL</topic><topic>B cells</topic><topic>B-Lymphocytes - metabolism</topic><topic>Blotting, Western - methods</topic><topic>Cell Count - methods</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Gene Expression Regulation - physiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Membrane Proteins - blood</topic><topic>Membrane Proteins - cerebrospinal fluid</topic><topic>Membrane Proteins - genetics</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - classification</topic><topic>Multiple Sclerosis - genetics</topic><topic>Multiple Sclerosis - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - metabolism</topic><topic>Tumor Necrosis Factor Ligand Superfamily Member 13</topic><topic>Tumor Necrosis Factor-alpha - cerebrospinal fluid</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>X-Linked Inhibitor of Apoptosis Protein - genetics</topic><topic>X-Linked Inhibitor of Apoptosis Protein - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thangarajh, Mathula</creatorcontrib><creatorcontrib>Masterman, Thomas</creatorcontrib><creatorcontrib>Rot, Uroš</creatorcontrib><creatorcontrib>Duvefelt, Kristina</creatorcontrib><creatorcontrib>Brynedal, Boel</creatorcontrib><creatorcontrib>Karrenbauer, Virginija Danylaité</creatorcontrib><creatorcontrib>Hillert, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thangarajh, Mathula</au><au>Masterman, Thomas</au><au>Rot, Uroš</au><au>Duvefelt, Kristina</au><au>Brynedal, Boel</au><au>Karrenbauer, Virginija Danylaité</au><au>Hillert, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased levels of APRIL (A Proliferation-Inducing Ligand) mRNA in multiple sclerosis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>167</volume><issue>1</issue><spage>210</spage><epage>214</epage><pages>210-214</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL–a promotor of B-cell survival–in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls.
APRIL mRNA levels in monocytes and T cells were significantly higher in MS patients than in controls. Levels of soluble APRIL in plasma were higher in patients with chronic progressive MS than in patients with relapsing–remitting MS, albeit not significantly.
MS may thus be associated with increased transcription in peripheral blood of factors promoting B-cell survival, including APRIL.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16087247</pmid><doi>10.1016/j.jneuroim.2005.06.024</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged APRIL B cells B-Lymphocytes - metabolism Blotting, Western - methods Cell Count - methods Child Child, Preschool Female Gene Expression Regulation - physiology Humans Infant Infant, Newborn Leukocytes - metabolism Male Membrane Proteins - blood Membrane Proteins - cerebrospinal fluid Membrane Proteins - genetics Middle Aged Multiple sclerosis Multiple Sclerosis - classification Multiple Sclerosis - genetics Multiple Sclerosis - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism Tumor Necrosis Factor Ligand Superfamily Member 13 Tumor Necrosis Factor-alpha - cerebrospinal fluid Tumor Necrosis Factor-alpha - genetics X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism |
| title | Increased levels of APRIL (A Proliferation-Inducing Ligand) mRNA in multiple sclerosis |
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