Swedish Rectal Cancer Trial: Long Lasting Benefits From Radiotherapy on Survival and Local Recurrence Rate
To evaluate the long-term effects on survival and recurrence rates of preoperative radiotherapy in the treatment of curatively operated rectal cancer patients. Of 1,168 randomly assigned patients in the Swedish Rectal Cancer Trial between 1987 and 1990, 908 had curative surgery; 454 of these patient...
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| Veröffentlicht in: | Journal of clinical oncology 2005-08, Vol.23 (24), p.5644-5650 |
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| container_title | Journal of clinical oncology |
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| creator | FOLKESSON, Joakim BIRGISSON, Helgi PAHLMAN, Lars CEDERMARK, Bjorn GLIMELIUS, Bengt GUNNARSSON, Ulf |
| description | To evaluate the long-term effects on survival and recurrence rates of preoperative radiotherapy in the treatment of curatively operated rectal cancer patients.
Of 1,168 randomly assigned patients in the Swedish Rectal Cancer Trial between 1987 and 1990, 908 had curative surgery; 454 of these patients had surgery alone, and 454 were administered preoperative radiotherapy (25 Gy in 5 days) followed by surgery within 1 week. Follow-up was performed by matching against three Swedish nationwide registries (the Swedish Cancer Register, the Hospital Discharge Register, and the Cause of Death Register).
Median follow-up time was 13 years (range, 3 to 15 years). The overall survival rate in the irradiated group was 38% v 30% in the nonirradiated group (P = .008). The cancer-specific survival rate in the irradiated group was 72% v 62% in the nonirradiated group (P = .03), and the local recurrence rate was 9% v 26% (P < .001), respectively. The reduction of local recurrence rates was observed at all tumor heights, although it was not statistically significant for tumors greater than 10 cm from the anal verge.
Preoperative radiotherapy with 25 Gy in 1 week before curative surgery for rectal cancer is beneficial for overall and cancer-specific survival and local recurrence rates after long-term follow-up. |
| doi_str_mv | 10.1200/JCO.2005.08.144 |
| format | Article |
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Of 1,168 randomly assigned patients in the Swedish Rectal Cancer Trial between 1987 and 1990, 908 had curative surgery; 454 of these patients had surgery alone, and 454 were administered preoperative radiotherapy (25 Gy in 5 days) followed by surgery within 1 week. Follow-up was performed by matching against three Swedish nationwide registries (the Swedish Cancer Register, the Hospital Discharge Register, and the Cause of Death Register).
Median follow-up time was 13 years (range, 3 to 15 years). The overall survival rate in the irradiated group was 38% v 30% in the nonirradiated group (P = .008). The cancer-specific survival rate in the irradiated group was 72% v 62% in the nonirradiated group (P = .03), and the local recurrence rate was 9% v 26% (P < .001), respectively. The reduction of local recurrence rates was observed at all tumor heights, although it was not statistically significant for tumors greater than 10 cm from the anal verge.
Preoperative radiotherapy with 25 Gy in 1 week before curative surgery for rectal cancer is beneficial for overall and cancer-specific survival and local recurrence rates after long-term follow-up.</description><identifier>ISSN: 0732-183X</identifier><identifier>ISSN: 1527-7755</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/JCO.2005.08.144</identifier><identifier>PMID: 16110023</identifier><language>eng</language><publisher>Baltimore, MD: American Society of Clinical Oncology</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Chi-Square Distribution ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Preoperative Care ; Rectal Neoplasms - radiotherapy ; Rectal Neoplasms - surgery ; Rectal Neoplasms/radiotherapy/surgery ; Registries ; Statistics, Nonparametric ; Survival Rate ; Sweden ; Treatment Outcome ; Tumors</subject><ispartof>Journal of clinical oncology, 2005-08, Vol.23 (24), p.5644-5650</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-1e0c4f1a13cd3e9cdc6737f498d8e7f5ebe4e754e44846fe2463c45901fe99973</citedby><cites>FETCH-LOGICAL-c611t-1e0c4f1a13cd3e9cdc6737f498d8e7f5ebe4e754e44846fe2463c45901fe99973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3716,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17166989$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16110023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-86598$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-74650$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-94885$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1935842$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>FOLKESSON, Joakim</creatorcontrib><creatorcontrib>BIRGISSON, Helgi</creatorcontrib><creatorcontrib>PAHLMAN, Lars</creatorcontrib><creatorcontrib>CEDERMARK, Bjorn</creatorcontrib><creatorcontrib>GLIMELIUS, Bengt</creatorcontrib><creatorcontrib>GUNNARSSON, Ulf</creatorcontrib><title>Swedish Rectal Cancer Trial: Long Lasting Benefits From Radiotherapy on Survival and Local Recurrence Rate</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>To evaluate the long-term effects on survival and recurrence rates of preoperative radiotherapy in the treatment of curatively operated rectal cancer patients.
Of 1,168 randomly assigned patients in the Swedish Rectal Cancer Trial between 1987 and 1990, 908 had curative surgery; 454 of these patients had surgery alone, and 454 were administered preoperative radiotherapy (25 Gy in 5 days) followed by surgery within 1 week. Follow-up was performed by matching against three Swedish nationwide registries (the Swedish Cancer Register, the Hospital Discharge Register, and the Cause of Death Register).
Median follow-up time was 13 years (range, 3 to 15 years). The overall survival rate in the irradiated group was 38% v 30% in the nonirradiated group (P = .008). The cancer-specific survival rate in the irradiated group was 72% v 62% in the nonirradiated group (P = .03), and the local recurrence rate was 9% v 26% (P < .001), respectively. The reduction of local recurrence rates was observed at all tumor heights, although it was not statistically significant for tumors greater than 10 cm from the anal verge.
Preoperative radiotherapy with 25 Gy in 1 week before curative surgery for rectal cancer is beneficial for overall and cancer-specific survival and local recurrence rates after long-term follow-up.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Preoperative Care</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>Rectal Neoplasms/radiotherapy/surgery</subject><subject>Registries</subject><subject>Statistics, Nonparametric</subject><subject>Survival Rate</subject><subject>Sweden</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0732-183X</issn><issn>1527-7755</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s1v0zAYBnALgVgZnLmhXIADpLNjO7a5jcL4UKVJ20DcLNd507rko9jJqv33vFUjdkLa6bWsnx9b8kPIS0bnrKD07Pvico5TzqmeMyEekRmThcqVkvIxmVHFi5xp_uuEPEtpSykTmsun5ISVjFFa8BnZXu-hCmmTXYEfXJMtXOchZjcxuOZDtuy7dbZ0aQg4P0IHdRhSdhH7NrtyVeiHDUS3u8v6Lrse4224xQTXVXjO4wojxxgBA1EP8Jw8qV2T4MU0T8mPi883i6_58vLLt8X5Mvf4qiFnQL2omWPcVxyMr3ypuKqF0ZUGVUtYgQAlBQihRVlDIUruhTSU1WCMUfyU5MfctIfduLK7GFoX72zvgp22fuMKrFRGUIb-3X_9p_Dz3PZxbcfRGqG1fLBWopQU9fsH6Ha0upRGI39z5LvY_xkhDbYNyUPTuA76MdlSS8o0O8CzI_SxTylC_S-ZUXtohsVm2EMzLNUWm4EnXk3R46qF6t5PVUDwegIu4e_VEZsQ0r1TrCyNNujeHt0mrDf7EMGm1jUNxhZ26_uC20JYWeKVfwFDas9Z</recordid><startdate>20050820</startdate><enddate>20050820</enddate><creator>FOLKESSON, Joakim</creator><creator>BIRGISSON, Helgi</creator><creator>PAHLMAN, Lars</creator><creator>CEDERMARK, Bjorn</creator><creator>GLIMELIUS, Bengt</creator><creator>GUNNARSSON, Ulf</creator><general>American Society of Clinical Oncology</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D93</scope><scope>DF2</scope></search><sort><creationdate>20050820</creationdate><title>Swedish Rectal Cancer Trial: Long Lasting Benefits From Radiotherapy on Survival and Local Recurrence Rate</title><author>FOLKESSON, Joakim ; BIRGISSON, Helgi ; PAHLMAN, Lars ; CEDERMARK, Bjorn ; GLIMELIUS, Bengt ; GUNNARSSON, Ulf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-1e0c4f1a13cd3e9cdc6737f498d8e7f5ebe4e754e44846fe2463c45901fe99973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Preoperative Care</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Rectal Neoplasms - surgery</topic><topic>Rectal Neoplasms/radiotherapy/surgery</topic><topic>Registries</topic><topic>Statistics, Nonparametric</topic><topic>Survival Rate</topic><topic>Sweden</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FOLKESSON, Joakim</creatorcontrib><creatorcontrib>BIRGISSON, Helgi</creatorcontrib><creatorcontrib>PAHLMAN, Lars</creatorcontrib><creatorcontrib>CEDERMARK, Bjorn</creatorcontrib><creatorcontrib>GLIMELIUS, Bengt</creatorcontrib><creatorcontrib>GUNNARSSON, Ulf</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FOLKESSON, Joakim</au><au>BIRGISSON, Helgi</au><au>PAHLMAN, Lars</au><au>CEDERMARK, Bjorn</au><au>GLIMELIUS, Bengt</au><au>GUNNARSSON, Ulf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Swedish Rectal Cancer Trial: Long Lasting Benefits From Radiotherapy on Survival and Local Recurrence Rate</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>2005-08-20</date><risdate>2005</risdate><volume>23</volume><issue>24</issue><spage>5644</spage><epage>5650</epage><pages>5644-5650</pages><issn>0732-183X</issn><issn>1527-7755</issn><eissn>1527-7755</eissn><abstract>To evaluate the long-term effects on survival and recurrence rates of preoperative radiotherapy in the treatment of curatively operated rectal cancer patients.
Of 1,168 randomly assigned patients in the Swedish Rectal Cancer Trial between 1987 and 1990, 908 had curative surgery; 454 of these patients had surgery alone, and 454 were administered preoperative radiotherapy (25 Gy in 5 days) followed by surgery within 1 week. Follow-up was performed by matching against three Swedish nationwide registries (the Swedish Cancer Register, the Hospital Discharge Register, and the Cause of Death Register).
Median follow-up time was 13 years (range, 3 to 15 years). The overall survival rate in the irradiated group was 38% v 30% in the nonirradiated group (P = .008). The cancer-specific survival rate in the irradiated group was 72% v 62% in the nonirradiated group (P = .03), and the local recurrence rate was 9% v 26% (P < .001), respectively. The reduction of local recurrence rates was observed at all tumor heights, although it was not statistically significant for tumors greater than 10 cm from the anal verge.
Preoperative radiotherapy with 25 Gy in 1 week before curative surgery for rectal cancer is beneficial for overall and cancer-specific survival and local recurrence rates after long-term follow-up.</abstract><cop>Baltimore, MD</cop><pub>American Society of Clinical Oncology</pub><pmid>16110023</pmid><doi>10.1200/JCO.2005.08.144</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0732-183X |
| ispartof | Journal of clinical oncology, 2005-08, Vol.23 (24), p.5644-5650 |
| issn | 0732-183X 1527-7755 1527-7755 |
| language | eng |
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| source | MEDLINE; American Society of Clinical Oncology Online Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Biological and medical sciences Chi-Square Distribution Combined Modality Therapy Female Follow-Up Studies Humans Male Medical sciences Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Preoperative Care Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Rectal Neoplasms/radiotherapy/surgery Registries Statistics, Nonparametric Survival Rate Sweden Treatment Outcome Tumors |
| title | Swedish Rectal Cancer Trial: Long Lasting Benefits From Radiotherapy on Survival and Local Recurrence Rate |
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