Post-mortem human brain autoradiography of the norepinephrine transporter using ( S, S)-[ 18F]FMeNER-D 2
The binding of the norepinephrine transporter radioligand, ( S, S)-[ 18F]FMeNER-D 2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus ≫ cortex ≈ cerebellum ≈ thalamus > caudate ≈ putamen. The NET...
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| Veröffentlicht in: | European neuropsychopharmacology 2005, Vol.15 (5), p.517-520 |
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| container_title | European neuropsychopharmacology |
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| creator | Schou, Magnus Halldin, Christer Pike, Victor W. Mozley, P. David Dobson, David Innis, Robert B. Farde, Lars Hall, Håkan |
| description | The binding of the norepinephrine transporter radioligand, (
S,
S)-[
18F]FMeNER-D
2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus
≫
cortex
≈
cerebellum
≈
thalamus
>
caudate
≈
putamen. The NET-selectivity of binding was confirmed by co-incubation with desipramine. The dual NET/SERT inhibitor duloxetine also inhibited specific binding, whereas PE2I or citalopram had no evident effect. |
| doi_str_mv | 10.1016/j.euroneuro.2005.01.007 |
| format | Article |
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S,
S)-[
18F]FMeNER-D
2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus
≫
cortex
≈
cerebellum
≈
thalamus
>
caudate
≈
putamen. The NET-selectivity of binding was confirmed by co-incubation with desipramine. The dual NET/SERT inhibitor duloxetine also inhibited specific binding, whereas PE2I or citalopram had no evident effect.</description><identifier>ISSN: 0924-977X</identifier><identifier>EISSN: 1873-7862</identifier><identifier>DOI: 10.1016/j.euroneuro.2005.01.007</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>( S, S)-[ 18F]FMeNER-D 2 ; Autoradiography ; Human brain ; Norepinephrine transporter</subject><ispartof>European neuropsychopharmacology, 2005, Vol.15 (5), p.517-520</ispartof><rights>2005 Elsevier B.V. and ECNP</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0924977X05000386$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:111487925$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Schou, Magnus</creatorcontrib><creatorcontrib>Halldin, Christer</creatorcontrib><creatorcontrib>Pike, Victor W.</creatorcontrib><creatorcontrib>Mozley, P. David</creatorcontrib><creatorcontrib>Dobson, David</creatorcontrib><creatorcontrib>Innis, Robert B.</creatorcontrib><creatorcontrib>Farde, Lars</creatorcontrib><creatorcontrib>Hall, Håkan</creatorcontrib><title>Post-mortem human brain autoradiography of the norepinephrine transporter using ( S, S)-[ 18F]FMeNER-D 2</title><title>European neuropsychopharmacology</title><description>The binding of the norepinephrine transporter radioligand, (
S,
S)-[
18F]FMeNER-D
2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus
≫
cortex
≈
cerebellum
≈
thalamus
>
caudate
≈
putamen. The NET-selectivity of binding was confirmed by co-incubation with desipramine. The dual NET/SERT inhibitor duloxetine also inhibited specific binding, whereas PE2I or citalopram had no evident effect.</description><subject>( S, S)-[ 18F]FMeNER-D 2</subject><subject>Autoradiography</subject><subject>Human brain</subject><subject>Norepinephrine transporter</subject><issn>0924-977X</issn><issn>1873-7862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNo9kFtLxDAQhYMouF5-g3lUMHWSbJvmcVl3VVgveAFBJKTt1GZ1m5K2iv_eLrv4cmYYzhkOHyEnHCIOPLlYRtgHX68lEgBxBDwCUDtkxFMlmUoTsUtGoMWYaaVe98lB2y4BeCylHpHqwbcdW_nQ4YpW_crWNAvW1dT2nQ-2cP4j2Kb6pb6kXYW09gEbV2NThUFpF2zdNut0oH3r6g96Sp_O6dMZe6M8nb_Pb_Fu9sguqTgie6X9avF4Ow_Jy3z2PL1mi_urm-lkwZCnvGN5ouOxEFrCWCYxtzIVAhKdCBQisdyqNJNKCyilzlRe2HIMUpZQIJeY5baQh4Rt_rY_2PSZaYJb2fBrvHVme_ocNjSx0lyLwT_Z-HEo9e0wmDZ3WOdYuIB5ZwrvDAezRm2W5h-1WaM2wM2AWv4BGf92Kw</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Schou, Magnus</creator><creator>Halldin, Christer</creator><creator>Pike, Victor W.</creator><creator>Mozley, P. David</creator><creator>Dobson, David</creator><creator>Innis, Robert B.</creator><creator>Farde, Lars</creator><creator>Hall, Håkan</creator><general>Elsevier B.V</general><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>2005</creationdate><title>Post-mortem human brain autoradiography of the norepinephrine transporter using ( S, S)-[ 18F]FMeNER-D 2</title><author>Schou, Magnus ; Halldin, Christer ; Pike, Victor W. ; Mozley, P. David ; Dobson, David ; Innis, Robert B. ; Farde, Lars ; Hall, Håkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e181t-c69542293043651a382206962e226a1a78b37920f39b7cdaf4033f0de13ebcad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>( S, S)-[ 18F]FMeNER-D 2</topic><topic>Autoradiography</topic><topic>Human brain</topic><topic>Norepinephrine transporter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schou, Magnus</creatorcontrib><creatorcontrib>Halldin, Christer</creatorcontrib><creatorcontrib>Pike, Victor W.</creatorcontrib><creatorcontrib>Mozley, P. David</creatorcontrib><creatorcontrib>Dobson, David</creatorcontrib><creatorcontrib>Innis, Robert B.</creatorcontrib><creatorcontrib>Farde, Lars</creatorcontrib><creatorcontrib>Hall, Håkan</creatorcontrib><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>European neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schou, Magnus</au><au>Halldin, Christer</au><au>Pike, Victor W.</au><au>Mozley, P. David</au><au>Dobson, David</au><au>Innis, Robert B.</au><au>Farde, Lars</au><au>Hall, Håkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-mortem human brain autoradiography of the norepinephrine transporter using ( S, S)-[ 18F]FMeNER-D 2</atitle><jtitle>European neuropsychopharmacology</jtitle><date>2005</date><risdate>2005</risdate><volume>15</volume><issue>5</issue><spage>517</spage><epage>520</epage><pages>517-520</pages><issn>0924-977X</issn><eissn>1873-7862</eissn><abstract>The binding of the norepinephrine transporter radioligand, (
S,
S)-[
18F]FMeNER-D
2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus
≫
cortex
≈
cerebellum
≈
thalamus
>
caudate
≈
putamen. The NET-selectivity of binding was confirmed by co-incubation with desipramine. The dual NET/SERT inhibitor duloxetine also inhibited specific binding, whereas PE2I or citalopram had no evident effect.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.euroneuro.2005.01.007</doi><tpages>4</tpages></addata></record> |
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| ispartof | European neuropsychopharmacology, 2005, Vol.15 (5), p.517-520 |
| issn | 0924-977X 1873-7862 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | ( S, S)-[ 18F]FMeNER-D 2 Autoradiography Human brain Norepinephrine transporter |
| title | Post-mortem human brain autoradiography of the norepinephrine transporter using ( S, S)-[ 18F]FMeNER-D 2 |
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