Profound but transient deficits in learning and memory after global ischemia using a novel water maze test

The pyramidal CA1 neurons of the hippocampus are critically involved in spatial learning and memory. These neurons are especially vulnerable to cerebral ischemia, but in spite of this, it has been consistently difficult to show any learning and memory deficits in two-vessel occlusion models of globa...

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Veröffentlicht in:	Behavioural brain research 2006-01, Vol.166 (2), p.204-210
Hauptverfasser:	von Euler, Mia, Bendel, Olof, Bueters, Tjerk, Sandin, Johan, von Euler, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anatomical correlates of behavior Animal Animal model Animals Behavior, Animal Behavioral psychophysiology Biological and medical sciences Body Weight - physiology Brain Ischemia - complications Brain Ischemia - metabolism Brain Ischemia - pathology Cell Death - physiology Cerebrovascular Circulation - physiology Cognitive impairment Functional Laterality - physiology Fundamental and applied biological sciences. Psychology Global ischemia Hippocampus Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiopathology Immunohistochemistry - methods In Situ Nick-End Labeling - methods Laser-Doppler Flowmetry - methods Learning Learning Disorders - etiology Learning Disorders - metabolism Learning Disorders - pathology Learning. Memory Male Maze Learning - physiology Medicin och hälsovetenskap Memory Disorders - etiology Memory Disorders - metabolism Memory Disorders - pathology Phosphopyruvate Hydratase - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Selective neuronal death Time Factors
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