Non-invasive and microinvasive electrical impedance spectra of skin cancer - a comparison between two techniques
Background/purpose: Bio‐electrical impedance spectra of skin cancer and other lesions can be assessed using both regular non‐invasive probes and a novel type of microinvasive electrode system with a surface furnished with tiny spikes that penetrate stratum corneum. The aim of the study was to compar...
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Veröffentlicht in: | Skin research and technology 2005-11, Vol.11 (4), p.281-286 |
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creator | Åberg, Peter Geladi, Paul Nicander, Ingrid Hansson, Johan Holmgren, Ulf Ollmar, Stig |
description | Background/purpose: Bio‐electrical impedance spectra of skin cancer and other lesions can be assessed using both regular non‐invasive probes and a novel type of microinvasive electrode system with a surface furnished with tiny spikes that penetrate stratum corneum. The aim of the study was to compare the accuracy of detection for various types of skin cancer using impedance spectra measured with these two different electrode systems in an objective way without optimising the power of discrimination.
Methods: Impedance spectra of 99 benign nevi, 28 basal cell carcinomas (BCC), and 13 malignant melanomas (MM) were measured using the two electrode systems. Classification of the lesions was made using Fisher's linear discriminant, and the sensitivities and specificities of the techniques were estimated using cross‐validation.
Results: The best separation between nevi and BCC was achieved using the regular non‐invasive probe (96% sensitivity and 86% specificity), whereas the best separation between nevi and MM was achieved using the microinvasive electrodes (92% sensitivity and 80% specificity).
Conclusions: Our results indicate that the choice of electrode system is application dependent. |
doi_str_mv | 10.1111/j.0909-725X.2005.00125.x |
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Methods: Impedance spectra of 99 benign nevi, 28 basal cell carcinomas (BCC), and 13 malignant melanomas (MM) were measured using the two electrode systems. Classification of the lesions was made using Fisher's linear discriminant, and the sensitivities and specificities of the techniques were estimated using cross‐validation.
Results: The best separation between nevi and BCC was achieved using the regular non‐invasive probe (96% sensitivity and 86% specificity), whereas the best separation between nevi and MM was achieved using the microinvasive electrodes (92% sensitivity and 80% specificity).
Conclusions: Our results indicate that the choice of electrode system is application dependent.</description><identifier>ISSN: 0909-752X</identifier><identifier>ISSN: 1600-0846</identifier><identifier>EISSN: 1600-0846</identifier><identifier>DOI: 10.1111/j.0909-725X.2005.00125.x</identifier><identifier>PMID: 16221145</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>basal cell carcinoma ; bio-electrical impedance ; Carcinoma, Basal Cell - diagnosis ; Carcinoma, Basal Cell - physiopathology ; Diagnosis, Differential ; Electric Impedance ; Humans ; lesions ; malignant melanoma ; Medicin och hälsovetenskap ; Melanoma - diagnosis ; Melanoma - physiopathology ; microinvasive ; Nevus - diagnosis ; Nevus - physiopathology ; Reproducibility of Results ; Sensitivity and Specificity ; Skin Neoplasms - diagnosis ; Skin Neoplasms - physiopathology ; Spectrum Analysis - methods</subject><ispartof>Skin research and technology, 2005-11, Vol.11 (4), p.281-286</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5585-4b8c89f3665d76e30ce460f53cb235879aa2042da40ef7340b6200f4fea471713</citedby><cites>FETCH-LOGICAL-c5585-4b8c89f3665d76e30ce460f53cb235879aa2042da40ef7340b6200f4fea471713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.0909-725X.2005.00125.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.0909-725X.2005.00125.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.0909-725X.2005.00125.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16221145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-15103$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1940557$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Åberg, Peter</creatorcontrib><creatorcontrib>Geladi, Paul</creatorcontrib><creatorcontrib>Nicander, Ingrid</creatorcontrib><creatorcontrib>Hansson, Johan</creatorcontrib><creatorcontrib>Holmgren, Ulf</creatorcontrib><creatorcontrib>Ollmar, Stig</creatorcontrib><title>Non-invasive and microinvasive electrical impedance spectra of skin cancer - a comparison between two techniques</title><title>Skin research and technology</title><addtitle>Skin Res Technol</addtitle><description>Background/purpose: Bio‐electrical impedance spectra of skin cancer and other lesions can be assessed using both regular non‐invasive probes and a novel type of microinvasive electrode system with a surface furnished with tiny spikes that penetrate stratum corneum. The aim of the study was to compare the accuracy of detection for various types of skin cancer using impedance spectra measured with these two different electrode systems in an objective way without optimising the power of discrimination.
Methods: Impedance spectra of 99 benign nevi, 28 basal cell carcinomas (BCC), and 13 malignant melanomas (MM) were measured using the two electrode systems. Classification of the lesions was made using Fisher's linear discriminant, and the sensitivities and specificities of the techniques were estimated using cross‐validation.
Results: The best separation between nevi and BCC was achieved using the regular non‐invasive probe (96% sensitivity and 86% specificity), whereas the best separation between nevi and MM was achieved using the microinvasive electrodes (92% sensitivity and 80% specificity).
Conclusions: Our results indicate that the choice of electrode system is application dependent.</description><subject>basal cell carcinoma</subject><subject>bio-electrical impedance</subject><subject>Carcinoma, Basal Cell - diagnosis</subject><subject>Carcinoma, Basal Cell - physiopathology</subject><subject>Diagnosis, Differential</subject><subject>Electric Impedance</subject><subject>Humans</subject><subject>lesions</subject><subject>malignant melanoma</subject><subject>Medicin och hälsovetenskap</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - physiopathology</subject><subject>microinvasive</subject><subject>Nevus - diagnosis</subject><subject>Nevus - physiopathology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - physiopathology</subject><subject>Spectrum Analysis - methods</subject><issn>0909-752X</issn><issn>1600-0846</issn><issn>1600-0846</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEokvhLyCfOJEwjr8SiUu1QEFUBW0L9GY5zoR6N1_E2e723-Owy-6pAl9svXreGWvmjSJCIaHhvFkmkEMeq1TcJCmASABoKpLto2hGJUAMGZePo9kOEunNSfTM-yUEMqfsaXRCZZpSysUs6i-7NnbtnfHuDolpS9I4O3QHBWu04-CsqYlreixNa5H4fhIN6SriV64ldlIHEhNDbNf0ZnC-a0mB4waxJeOmIyPa29b9WqN_Hj2pTO3xxf4-jb59eH89_xhffDn_ND-7iK0QmYh5kdksr5iUolQSGVjkEirBbJEykancmBR4WhoOWCnGoZBhEBWv0HBFFWWnUbyr6zfYrwvdD64xw73ujNN7aRVeqIXKRA6BVw_y_dCVR9NfI805CKGC8_WDznfu-5nuhp96Nd5qKiiwgL_a4aHqNJBRN85brGvTYrf2WmYyB8Wyf4KhP82pnMBsB4bFeT9gdfgCBT3lRS_1FAU95UVPedF_8qK3wfpy32NdNFgejfuABODtDti4Gu__u7C-WlyHx3ELzo-4PdjNsNJSMSX0j8tz_ZWnnxdXC9Bz9hvRpOB9</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Åberg, Peter</creator><creator>Geladi, Paul</creator><creator>Nicander, Ingrid</creator><creator>Hansson, Johan</creator><creator>Holmgren, Ulf</creator><creator>Ollmar, Stig</creator><general>Munksgaard International Publishers</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8V</scope></search><sort><creationdate>200511</creationdate><title>Non-invasive and microinvasive electrical impedance spectra of skin cancer - a comparison between two techniques</title><author>Åberg, Peter ; Geladi, Paul ; Nicander, Ingrid ; Hansson, Johan ; Holmgren, Ulf ; Ollmar, Stig</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5585-4b8c89f3665d76e30ce460f53cb235879aa2042da40ef7340b6200f4fea471713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>basal cell carcinoma</topic><topic>bio-electrical impedance</topic><topic>Carcinoma, Basal Cell - diagnosis</topic><topic>Carcinoma, Basal Cell - physiopathology</topic><topic>Diagnosis, Differential</topic><topic>Electric Impedance</topic><topic>Humans</topic><topic>lesions</topic><topic>malignant melanoma</topic><topic>Medicin och hälsovetenskap</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - physiopathology</topic><topic>microinvasive</topic><topic>Nevus - diagnosis</topic><topic>Nevus - physiopathology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - physiopathology</topic><topic>Spectrum Analysis - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Åberg, Peter</creatorcontrib><creatorcontrib>Geladi, Paul</creatorcontrib><creatorcontrib>Nicander, Ingrid</creatorcontrib><creatorcontrib>Hansson, Johan</creatorcontrib><creatorcontrib>Holmgren, Ulf</creatorcontrib><creatorcontrib>Ollmar, Stig</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Kungliga Tekniska Högskolan</collection><jtitle>Skin research and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Åberg, Peter</au><au>Geladi, Paul</au><au>Nicander, Ingrid</au><au>Hansson, Johan</au><au>Holmgren, Ulf</au><au>Ollmar, Stig</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-invasive and microinvasive electrical impedance spectra of skin cancer - a comparison between two techniques</atitle><jtitle>Skin research and technology</jtitle><addtitle>Skin Res Technol</addtitle><date>2005-11</date><risdate>2005</risdate><volume>11</volume><issue>4</issue><spage>281</spage><epage>286</epage><pages>281-286</pages><issn>0909-752X</issn><issn>1600-0846</issn><eissn>1600-0846</eissn><abstract>Background/purpose: Bio‐electrical impedance spectra of skin cancer and other lesions can be assessed using both regular non‐invasive probes and a novel type of microinvasive electrode system with a surface furnished with tiny spikes that penetrate stratum corneum. The aim of the study was to compare the accuracy of detection for various types of skin cancer using impedance spectra measured with these two different electrode systems in an objective way without optimising the power of discrimination.
Methods: Impedance spectra of 99 benign nevi, 28 basal cell carcinomas (BCC), and 13 malignant melanomas (MM) were measured using the two electrode systems. Classification of the lesions was made using Fisher's linear discriminant, and the sensitivities and specificities of the techniques were estimated using cross‐validation.
Results: The best separation between nevi and BCC was achieved using the regular non‐invasive probe (96% sensitivity and 86% specificity), whereas the best separation between nevi and MM was achieved using the microinvasive electrodes (92% sensitivity and 80% specificity).
Conclusions: Our results indicate that the choice of electrode system is application dependent.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>16221145</pmid><doi>10.1111/j.0909-725X.2005.00125.x</doi><tpages>6</tpages></addata></record> |
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subjects | basal cell carcinoma bio-electrical impedance Carcinoma, Basal Cell - diagnosis Carcinoma, Basal Cell - physiopathology Diagnosis, Differential Electric Impedance Humans lesions malignant melanoma Medicin och hälsovetenskap Melanoma - diagnosis Melanoma - physiopathology microinvasive Nevus - diagnosis Nevus - physiopathology Reproducibility of Results Sensitivity and Specificity Skin Neoplasms - diagnosis Skin Neoplasms - physiopathology Spectrum Analysis - methods |
title | Non-invasive and microinvasive electrical impedance spectra of skin cancer - a comparison between two techniques |
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