Non-invasive and microinvasive electrical impedance spectra of skin cancer - a comparison between two techniques

Background/purpose: Bio‐electrical impedance spectra of skin cancer and other lesions can be assessed using both regular non‐invasive probes and a novel type of microinvasive electrode system with a surface furnished with tiny spikes that penetrate stratum corneum. The aim of the study was to compar...

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Veröffentlicht in:Skin research and technology 2005-11, Vol.11 (4), p.281-286
Hauptverfasser: Åberg, Peter, Geladi, Paul, Nicander, Ingrid, Hansson, Johan, Holmgren, Ulf, Ollmar, Stig
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container_end_page 286
container_issue 4
container_start_page 281
container_title Skin research and technology
container_volume 11
creator Åberg, Peter
Geladi, Paul
Nicander, Ingrid
Hansson, Johan
Holmgren, Ulf
Ollmar, Stig
description Background/purpose: Bio‐electrical impedance spectra of skin cancer and other lesions can be assessed using both regular non‐invasive probes and a novel type of microinvasive electrode system with a surface furnished with tiny spikes that penetrate stratum corneum. The aim of the study was to compare the accuracy of detection for various types of skin cancer using impedance spectra measured with these two different electrode systems in an objective way without optimising the power of discrimination. Methods: Impedance spectra of 99 benign nevi, 28 basal cell carcinomas (BCC), and 13 malignant melanomas (MM) were measured using the two electrode systems. Classification of the lesions was made using Fisher's linear discriminant, and the sensitivities and specificities of the techniques were estimated using cross‐validation. Results: The best separation between nevi and BCC was achieved using the regular non‐invasive probe (96% sensitivity and 86% specificity), whereas the best separation between nevi and MM was achieved using the microinvasive electrodes (92% sensitivity and 80% specificity). Conclusions: Our results indicate that the choice of electrode system is application dependent.
doi_str_mv 10.1111/j.0909-725X.2005.00125.x
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The aim of the study was to compare the accuracy of detection for various types of skin cancer using impedance spectra measured with these two different electrode systems in an objective way without optimising the power of discrimination. Methods: Impedance spectra of 99 benign nevi, 28 basal cell carcinomas (BCC), and 13 malignant melanomas (MM) were measured using the two electrode systems. Classification of the lesions was made using Fisher's linear discriminant, and the sensitivities and specificities of the techniques were estimated using cross‐validation. Results: The best separation between nevi and BCC was achieved using the regular non‐invasive probe (96% sensitivity and 86% specificity), whereas the best separation between nevi and MM was achieved using the microinvasive electrodes (92% sensitivity and 80% specificity). 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subjects basal cell carcinoma
bio-electrical impedance
Carcinoma, Basal Cell - diagnosis
Carcinoma, Basal Cell - physiopathology
Diagnosis, Differential
Electric Impedance
Humans
lesions
malignant melanoma
Medicin och hälsovetenskap
Melanoma - diagnosis
Melanoma - physiopathology
microinvasive
Nevus - diagnosis
Nevus - physiopathology
Reproducibility of Results
Sensitivity and Specificity
Skin Neoplasms - diagnosis
Skin Neoplasms - physiopathology
Spectrum Analysis - methods
title Non-invasive and microinvasive electrical impedance spectra of skin cancer - a comparison between two techniques
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