Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons

Proneural genes are crucial regulators of neurogenesis and subtype specification in many areas of the nervous system; however, their function in dopaminergic neuron development is unknown. We report that proneural genes have an intricate pattern of expression in the ventricular zone of the ventral m...

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Veröffentlicht in:	Development (Cambridge) 2006-02, Vol.133 (3), p.495-505
Hauptverfasser:	Kele, Julianna, Simplicio, Nicolas, Ferri, Anna L M, Mira, Helena, Guillemot, François, Arenas, Ernest, Ang, Siew-Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Differentiation - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dopamine - metabolism Female Homeodomain Proteins - metabolism In Situ Hybridization LIM-Homeodomain Proteins Male Mesencephalon - cytology Mesencephalon - embryology Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - cytology Neurons - physiology Nuclear Receptor Subfamily 4, Group A, Member 2 SOXB1 Transcription Factors Stem Cells - cytology Stem Cells - physiology Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Tyrosine 3-Monooxygenase - metabolism
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