Corticosterone Actions on the Hippocampal Brain-Derived Neurotrophic Factor Expression are Mediated by Exon IV Promoter

Brain‐derived neurotrophic factor (BDNF) expression is strongly regulated by adrenocorticosteroids via activated gluco‐ and mineralocorticoid receptors. Four separate promoters are located upstream of the BDNF noncoding exons I to IV and may thus be involved in adrenocorticosteroid‐mediated gene reg...

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Veröffentlicht in:	Journal of neuroendocrinology 2006-02, Vol.18 (2), p.104-114
Hauptverfasser:	Hansson, A. C., Sommer, W. H., Metsis, M., Strömberg, I., Agnati, L. F., Fuxe, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Analysis of Variance Animals Biological and medical sciences brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor/genetics/metabolism Corticosterone - blood Corticosterone - physiology Corticosterone/blood/physiology Down-Regulation Exons - genetics Exons - physiology Exons/genetics/physiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology glucocorticoids Hippocampus - metabolism Male neurotrophin Promoter Regions (Genetics)/physiology Promoter Regions, Genetic - physiology rat brain rat brain neurotrophin Rats Rats, Sprague-Dawley RNA, Messenger - analysis Time Factors Transcription, Genetic - physiology Vertebrates: endocrinology
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