IgE-positive plasma cells are present in adenoids of atopic children
Conclusions. We demonstrated the presence of IgE+ plasma cells in the adenoids of atopic children. Our data suggest that adenoids are capable of local production of IgE and support the role of adenoids as an inductive site for allergic reactions. Objective. We have previously demonstrated increased...
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| Veröffentlicht in: | Acta oto-laryngologica 2006-02, Vol.126 (2), p.180-185 |
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| creator | Papatziamos, Georgios Van Hage-Hamsten, Marianne Lundahl, Joachim Hemlin, Claes |
| description | Conclusions. We demonstrated the presence of IgE+ plasma cells in the adenoids of atopic children. Our data suggest that adenoids are capable of local production of IgE and support the role of adenoids as an inductive site for allergic reactions. Objective. We have previously demonstrated increased numbers of IgE+ cells in the adenoids of atopic children and also found support for an IL-4-induced class switch to IgE production in adenoids. In search of further evidence of adenoids being involved in IgE-mediated sensitization, we investigated the distribution of plasma cells and macrophages positive for IgE in adenoids. Material and methods. Adenoid tissue from atopic and non-atopic children was examined using immunohistochemical markers for IgE, plasma cells (CD138) and macrophages (CD68). The distribution of positive cells was determined in the extrafollicular area and in the follicles of adenoids. Co-localization of IgE and CD138+ plasma cells and CD68+ macrophages was examined using immunohistochemical double-staining methods. Results. Non-atopic adenoids contained no or very few IgE+ cells. In contrast, IgE+ cells were found in high numbers in atopic adenoids, mainly in the extrafollicular area. Higher numbers of IgE+ plasma cells and IgE+ macrophages were also found in the adenoids of atopic children. |
| doi_str_mv | 10.1080/00016480500265976 |
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We demonstrated the presence of IgE+ plasma cells in the adenoids of atopic children. Our data suggest that adenoids are capable of local production of IgE and support the role of adenoids as an inductive site for allergic reactions. Objective. We have previously demonstrated increased numbers of IgE+ cells in the adenoids of atopic children and also found support for an IL-4-induced class switch to IgE production in adenoids. In search of further evidence of adenoids being involved in IgE-mediated sensitization, we investigated the distribution of plasma cells and macrophages positive for IgE in adenoids. Material and methods. Adenoid tissue from atopic and non-atopic children was examined using immunohistochemical markers for IgE, plasma cells (CD138) and macrophages (CD68). The distribution of positive cells was determined in the extrafollicular area and in the follicles of adenoids. Co-localization of IgE and CD138+ plasma cells and CD68+ macrophages was examined using immunohistochemical double-staining methods. Results. Non-atopic adenoids contained no or very few IgE+ cells. In contrast, IgE+ cells were found in high numbers in atopic adenoids, mainly in the extrafollicular area. Higher numbers of IgE+ plasma cells and IgE+ macrophages were also found in the adenoids of atopic children.</description><identifier>ISSN: 0001-6489</identifier><identifier>EISSN: 1651-2251</identifier><identifier>DOI: 10.1080/00016480500265976</identifier><identifier>PMID: 16428197</identifier><identifier>CODEN: AOLAAJ</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Adenoid ; Adenoids - cytology ; Adenoids - immunology ; Antigens, CD - analysis ; Antigens, Differentiation, Myelomonocytic - analysis ; atopy ; Biological and medical sciences ; Case-Control Studies ; Child ; Female ; Humans ; Hypersensitivity, Immediate - immunology ; IgE ; Immunoglobulin E - analysis ; Immunoglobulin E - biosynthesis ; Immunoglobulin E - blood ; Immunohistochemistry ; macrophage ; Macrophages - immunology ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Otorhinolaryngology. Stomatology ; plasma cell ; Plasma Cells - immunology ; Syndecan-1 - analysis</subject><ispartof>Acta oto-laryngologica, 2006-02, Vol.126 (2), p.180-185</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-cbb05ffe54b53ecb21b9c39f5bfc047b91c51bb4553dce119deb3c9dc79cb2cd3</citedby><cites>FETCH-LOGICAL-c551t-cbb05ffe54b53ecb21b9c39f5bfc047b91c51bb4553dce119deb3c9dc79cb2cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00016480500265976$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00016480500265976$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17467926$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16428197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1948643$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Papatziamos, Georgios</creatorcontrib><creatorcontrib>Van Hage-Hamsten, Marianne</creatorcontrib><creatorcontrib>Lundahl, Joachim</creatorcontrib><creatorcontrib>Hemlin, Claes</creatorcontrib><title>IgE-positive plasma cells are present in adenoids of atopic children</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>Conclusions. We demonstrated the presence of IgE+ plasma cells in the adenoids of atopic children. Our data suggest that adenoids are capable of local production of IgE and support the role of adenoids as an inductive site for allergic reactions. Objective. We have previously demonstrated increased numbers of IgE+ cells in the adenoids of atopic children and also found support for an IL-4-induced class switch to IgE production in adenoids. In search of further evidence of adenoids being involved in IgE-mediated sensitization, we investigated the distribution of plasma cells and macrophages positive for IgE in adenoids. Material and methods. Adenoid tissue from atopic and non-atopic children was examined using immunohistochemical markers for IgE, plasma cells (CD138) and macrophages (CD68). The distribution of positive cells was determined in the extrafollicular area and in the follicles of adenoids. Co-localization of IgE and CD138+ plasma cells and CD68+ macrophages was examined using immunohistochemical double-staining methods. Results. Non-atopic adenoids contained no or very few IgE+ cells. In contrast, IgE+ cells were found in high numbers in atopic adenoids, mainly in the extrafollicular area. Higher numbers of IgE+ plasma cells and IgE+ macrophages were also found in the adenoids of atopic children.</description><subject>Adenoid</subject><subject>Adenoids - cytology</subject><subject>Adenoids - immunology</subject><subject>Antigens, CD - analysis</subject><subject>Antigens, Differentiation, Myelomonocytic - analysis</subject><subject>atopy</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>IgE</subject><subject>Immunoglobulin E - analysis</subject><subject>Immunoglobulin E - biosynthesis</subject><subject>Immunoglobulin E - blood</subject><subject>Immunohistochemistry</subject><subject>macrophage</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>plasma cell</subject><subject>Plasma Cells - immunology</subject><subject>Syndecan-1 - analysis</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks-P1SAQgInRuM_VP8CL6UVvVaCllOjFrKtusokXPRN-DD5WWiq0bva_l_q6vhjjegKG75sMMyD0lOCXBPf4FcaYdG2PGca0Y4J399COdIzUlDJyH-3W-7oA4gQ9yvlqPYqePUQnxaI9EXyH3l18Pa-nmP3sf0A1BZUHVRkIIVcqlUCCDONc-bFSFsboba6iq9QcJ28qs_fBJhgfowdOhQxPtvUUfXl__vnsY3356cPF2dvL2jBG5tpojZlzwFrNGjCaEi1MIxzTzuCWa0EMI1q3jDXWACHCgm6MsIaLAhvbnKL6kDdfw7RoOSU_qHQjo_JyC30rO5CMc0q7wvN_8lOK9ijdikS0fdc2xXxxMAv2fYE8y8HntS1qhLhkyXHX87Yj_wUpFozQZgXJATQp5pzA_a6GYLlOU_41zeI825IvegB7NLbxFeD5BqhsVHBJjcbnI1dK5OJXI94cOD-6mAZ1HVOwclY3IaZbqbmrjtd_6HtQYd6b8kHkVVzSWGZ-xyt-AqSVzjw</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Papatziamos, Georgios</creator><creator>Van Hage-Hamsten, Marianne</creator><creator>Lundahl, Joachim</creator><creator>Hemlin, Claes</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>8BM</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20060201</creationdate><title>IgE-positive plasma cells are present in adenoids of atopic children</title><author>Papatziamos, Georgios ; Van Hage-Hamsten, Marianne ; Lundahl, Joachim ; Hemlin, Claes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-cbb05ffe54b53ecb21b9c39f5bfc047b91c51bb4553dce119deb3c9dc79cb2cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenoid</topic><topic>Adenoids - cytology</topic><topic>Adenoids - immunology</topic><topic>Antigens, CD - analysis</topic><topic>Antigens, Differentiation, Myelomonocytic - analysis</topic><topic>atopy</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>IgE</topic><topic>Immunoglobulin E - analysis</topic><topic>Immunoglobulin E - biosynthesis</topic><topic>Immunoglobulin E - blood</topic><topic>Immunohistochemistry</topic><topic>macrophage</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>plasma cell</topic><topic>Plasma Cells - immunology</topic><topic>Syndecan-1 - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papatziamos, Georgios</creatorcontrib><creatorcontrib>Van Hage-Hamsten, Marianne</creatorcontrib><creatorcontrib>Lundahl, Joachim</creatorcontrib><creatorcontrib>Hemlin, Claes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papatziamos, Georgios</au><au>Van Hage-Hamsten, Marianne</au><au>Lundahl, Joachim</au><au>Hemlin, Claes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgE-positive plasma cells are present in adenoids of atopic children</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>126</volume><issue>2</issue><spage>180</spage><epage>185</epage><pages>180-185</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>Conclusions. We demonstrated the presence of IgE+ plasma cells in the adenoids of atopic children. Our data suggest that adenoids are capable of local production of IgE and support the role of adenoids as an inductive site for allergic reactions. Objective. We have previously demonstrated increased numbers of IgE+ cells in the adenoids of atopic children and also found support for an IL-4-induced class switch to IgE production in adenoids. In search of further evidence of adenoids being involved in IgE-mediated sensitization, we investigated the distribution of plasma cells and macrophages positive for IgE in adenoids. Material and methods. Adenoid tissue from atopic and non-atopic children was examined using immunohistochemical markers for IgE, plasma cells (CD138) and macrophages (CD68). The distribution of positive cells was determined in the extrafollicular area and in the follicles of adenoids. Co-localization of IgE and CD138+ plasma cells and CD68+ macrophages was examined using immunohistochemical double-staining methods. Results. Non-atopic adenoids contained no or very few IgE+ cells. In contrast, IgE+ cells were found in high numbers in atopic adenoids, mainly in the extrafollicular area. Higher numbers of IgE+ plasma cells and IgE+ macrophages were also found in the adenoids of atopic children.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>16428197</pmid><doi>10.1080/00016480500265976</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenoid Adenoids - cytology Adenoids - immunology Antigens, CD - analysis Antigens, Differentiation, Myelomonocytic - analysis atopy Biological and medical sciences Case-Control Studies Child Female Humans Hypersensitivity, Immediate - immunology IgE Immunoglobulin E - analysis Immunoglobulin E - biosynthesis Immunoglobulin E - blood Immunohistochemistry macrophage Macrophages - immunology Male Medical sciences Medicin och hälsovetenskap Otorhinolaryngology. Stomatology plasma cell Plasma Cells - immunology Syndecan-1 - analysis |
| title | IgE-positive plasma cells are present in adenoids of atopic children |
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