The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons
Neural crest cells (NCCs) can adopt different neuronal fates. In NCCs, neurogenin-2 promotes sensory specification but does not specify different subclasses of sensory neurons. Understanding the gene cascades that direct Trk gene activation may reveal mechanisms generating sensory diversity, because...
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| Veröffentlicht in: | Nature neuroscience 2006-02, Vol.9 (2), p.180-187 |
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| creator | Marmigère, Frédéric Montelius, Andreas Wegner, Michael Groner, Yoram Reichardt, Louis F Ernfors, Patrik |
| description | Neural crest cells (NCCs) can adopt different neuronal fates. In NCCs, neurogenin-2 promotes sensory specification but does not specify different subclasses of sensory neurons. Understanding the gene cascades that direct
Trk
gene activation may reveal mechanisms generating sensory diversity, because different Trks are expressed in different sensory neuron subpopulations. Here we show in chick and mouse that the Runt transcription factor Runx1 promotes axonal growth, is selectively expressed in neural crest–derived TrkA
+
sensory neurons and mediates TrkA transactivation in migratory NCCs. Inhibition of Runt activity depletes TrkA expression and leads to neuronal death. Moreover, Runx1 overexpression is incompatible with multipotency in the migratory neural crest but does not induce expression of pan-neuronal genes. Instead, Runx1-induced neuronal differentiation depends on an existing neurogenin2 proneural gene program. Our data show that Runx1 directs, in a context-dependent manner, key aspects of the establishment of the TrkA
+
nociceptive subclass of neurons. |
| doi_str_mv | 10.1038/nn1631 |
| format | Article |
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Trk
gene activation may reveal mechanisms generating sensory diversity, because different Trks are expressed in different sensory neuron subpopulations. Here we show in chick and mouse that the Runt transcription factor Runx1 promotes axonal growth, is selectively expressed in neural crest–derived TrkA
+
sensory neurons and mediates TrkA transactivation in migratory NCCs. Inhibition of Runt activity depletes TrkA expression and leads to neuronal death. Moreover, Runx1 overexpression is incompatible with multipotency in the migratory neural crest but does not induce expression of pan-neuronal genes. Instead, Runx1-induced neuronal differentiation depends on an existing neurogenin2 proneural gene program. Our data show that Runx1 directs, in a context-dependent manner, key aspects of the establishment of the TrkA
+
nociceptive subclass of neurons.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn1631</identifier><identifier>PMID: 16429136</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animal Genetics and Genomics ; Animals ; Apoptosis - physiology ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Cell cycle ; Cell Differentiation ; Cell Survival ; Cells, Cultured ; Chick Embryo ; Core Binding Factor Alpha 2 Subunit - physiology ; Electroporation ; Genes ; Immunohistochemistry ; In Situ Hybridization ; Influence ; Life Sciences ; Mice ; Neural circuitry ; Neural crest ; Neural Crest - cytology ; Neurobiology ; Neurons ; Neurons, Afferent - cytology ; Neurons, Afferent - physiology ; Neurosciences ; Nociceptors ; Nociceptors - cytology ; Nociceptors - physiology ; Receptor, trkA - genetics ; Receptor, trkA - metabolism ; Transcription factors ; Transcriptional Activation</subject><ispartof>Nature neuroscience, 2006-02, Vol.9 (2), p.180-187</ispartof><rights>Springer Nature America, Inc. 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2006</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2006 Nature Publishing Group 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c665t-8a37cec8eac4fa3d8f40dd194942af79608f4f25526360bc31af0bb5bbc784803</citedby><cites>FETCH-LOGICAL-c665t-8a37cec8eac4fa3d8f40dd194942af79608f4f25526360bc31af0bb5bbc784803</cites><orcidid>0000-0002-0515-7483</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nn1631$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nn1631$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16429136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03412521$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1931198$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Marmigère, Frédéric</creatorcontrib><creatorcontrib>Montelius, Andreas</creatorcontrib><creatorcontrib>Wegner, Michael</creatorcontrib><creatorcontrib>Groner, Yoram</creatorcontrib><creatorcontrib>Reichardt, Louis F</creatorcontrib><creatorcontrib>Ernfors, Patrik</creatorcontrib><title>The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>Neural crest cells (NCCs) can adopt different neuronal fates. In NCCs, neurogenin-2 promotes sensory specification but does not specify different subclasses of sensory neurons. Understanding the gene cascades that direct
Trk
gene activation may reveal mechanisms generating sensory diversity, because different Trks are expressed in different sensory neuron subpopulations. Here we show in chick and mouse that the Runt transcription factor Runx1 promotes axonal growth, is selectively expressed in neural crest–derived TrkA
+
sensory neurons and mediates TrkA transactivation in migratory NCCs. Inhibition of Runt activity depletes TrkA expression and leads to neuronal death. Moreover, Runx1 overexpression is incompatible with multipotency in the migratory neural crest but does not induce expression of pan-neuronal genes. Instead, Runx1-induced neuronal differentiation depends on an existing neurogenin2 proneural gene program. Our data show that Runx1 directs, in a context-dependent manner, key aspects of the establishment of the TrkA
+
nociceptive subclass of neurons.</description><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell cycle</subject><subject>Cell Differentiation</subject><subject>Cell Survival</subject><subject>Cells, Cultured</subject><subject>Chick Embryo</subject><subject>Core Binding Factor Alpha 2 Subunit - physiology</subject><subject>Electroporation</subject><subject>Genes</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Influence</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Neural circuitry</subject><subject>Neural crest</subject><subject>Neural Crest - cytology</subject><subject>Neurobiology</subject><subject>Neurons</subject><subject>Neurons, Afferent - cytology</subject><subject>Neurons, Afferent - physiology</subject><subject>Neurosciences</subject><subject>Nociceptors</subject><subject>Nociceptors - cytology</subject><subject>Nociceptors - physiology</subject><subject>Receptor, trkA - genetics</subject><subject>Receptor, trkA - metabolism</subject><subject>Transcription factors</subject><subject>Transcriptional Activation</subject><issn>1097-6256</issn><issn>1546-1726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNqFkk2P0zAQhiMEYpcFfgKyOIA4ZNcfsZ1ckKoVsCsVIS3lbDnOpPVuahc7Cdt_j0sjSntBPth655nXnvFk2WuCLwlm5ZVzRDDyJDsnvBA5kVQ8TWdcyVxQLs6yFzHeY4wlL6vn2RkRBa0IE-fZuFgBuhvcI7mafZ0T1Aftogl201vvUKtN7wOK0IHp7QjdFgVYDp3uIaIGkuA3a3A90q5BcQijHXWHfIsW4WGGnDfWwGaXmCxc9GGLHAzBu_gye9bqLsKrab_Ifnz-tLi-yeffvtxez-a5EYL3eamZNGBK0KZoNWvKtsBNQ6qiKqhuZSVwUlrKORVM4Nowoltc17yujSyLErOLLN_7xl-wGWq1CXatw1Z5bdUkPaQTKC4lJTLxH_d8iqyhMam2oLujtOOIsyu19KOiEjP5x-DD3mB1knYzm6udhllBKKdkJIl9N10W_M8BYq_WNhroOu3AD1FJLAnnWPwXJIksqSgT-PYEvPdDcKnD6YGFJBVlO-hyDy11B8q61qdKTFoNrK3xDlqb9BlLLRG4wvxQ05SQmB4e-6UeYlS33--O2empJvgYA7R_m0Cw2k2q2k9qAt_82-kDNo1mAt5PX5dCbgnhUMuJ1W_n0PF_</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Marmigère, Frédéric</creator><creator>Montelius, Andreas</creator><creator>Wegner, Michael</creator><creator>Groner, Yoram</creator><creator>Reichardt, Louis F</creator><creator>Ernfors, Patrik</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-0515-7483</orcidid></search><sort><creationdate>20060201</creationdate><title>The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons</title><author>Marmigère, Frédéric ; Montelius, Andreas ; Wegner, Michael ; Groner, Yoram ; Reichardt, Louis F ; Ernfors, Patrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c665t-8a37cec8eac4fa3d8f40dd194942af79608f4f25526360bc31af0bb5bbc784803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Apoptosis - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marmigère, Frédéric</au><au>Montelius, Andreas</au><au>Wegner, Michael</au><au>Groner, Yoram</au><au>Reichardt, Louis F</au><au>Ernfors, Patrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>9</volume><issue>2</issue><spage>180</spage><epage>187</epage><pages>180-187</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Neural crest cells (NCCs) can adopt different neuronal fates. In NCCs, neurogenin-2 promotes sensory specification but does not specify different subclasses of sensory neurons. Understanding the gene cascades that direct
Trk
gene activation may reveal mechanisms generating sensory diversity, because different Trks are expressed in different sensory neuron subpopulations. Here we show in chick and mouse that the Runt transcription factor Runx1 promotes axonal growth, is selectively expressed in neural crest–derived TrkA
+
sensory neurons and mediates TrkA transactivation in migratory NCCs. Inhibition of Runt activity depletes TrkA expression and leads to neuronal death. Moreover, Runx1 overexpression is incompatible with multipotency in the migratory neural crest but does not induce expression of pan-neuronal genes. Instead, Runx1-induced neuronal differentiation depends on an existing neurogenin2 proneural gene program. Our data show that Runx1 directs, in a context-dependent manner, key aspects of the establishment of the TrkA
+
nociceptive subclass of neurons.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>16429136</pmid><doi>10.1038/nn1631</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0515-7483</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; SWEPUB Freely available online |
| subjects | Animal Genetics and Genomics Animals Apoptosis - physiology Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cell cycle Cell Differentiation Cell Survival Cells, Cultured Chick Embryo Core Binding Factor Alpha 2 Subunit - physiology Electroporation Genes Immunohistochemistry In Situ Hybridization Influence Life Sciences Mice Neural circuitry Neural crest Neural Crest - cytology Neurobiology Neurons Neurons, Afferent - cytology Neurons, Afferent - physiology Neurosciences Nociceptors Nociceptors - cytology Nociceptors - physiology Receptor, trkA - genetics Receptor, trkA - metabolism Transcription factors Transcriptional Activation |
| title | The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons |
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